Results 71 to 80 of about 27,595,942 (347)

Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex

Frontiers in Genetics, 2013
The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler, Dario L Balacco   +1 more
doaj   +1 more source

RNAseq by Total RNA Library Identifies Additional RNAs Compared to Poly(A) RNA Library

BioMed Research International, 2015
The most popular RNA library used for RNA sequencing is the poly(A) captured RNA library. This library captures RNA based on the presence of poly(A) tails at the 3′ end.
Yan Guo, Shilin Zhao, Quanhu Sheng, Ming-Rui Guo, B. Lehmann, J. Pietenpol, D. Samuels, Y. Shyr   +7 more
semanticscholar   +1 more source

Poly-MTO, {(CH_3)_{0.92} Re O_3}_\infty, a Conducting Two-Dimensional Organometallic Oxide [PDF]

, 2005
Polymeric methyltrioxorhenium, {(CH_{3})_{0.92}ReO_{3}}_{\infty} (poly-MTO), is the first member of a new class of organometallic hybrids which adopts the structural pattern and physical properties of classical perovskites in two dimensions (2D).
B. L. Altshuler, C. C. Tsuei, C. Helbig, C. Helbig, E.-W. Scheidt, F. Mayr, G. Eickerling, H.-A. Krug von Nidda, J. F. Gibson, J. Mink, J. T. Szymanski, P. Kiprof, P. Schwab, R. Herrmann, R. Miller, R. Miller, V. Eyert, W. A. Herrmann, W. Scherer   +18 more
core   +4 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Genome-wide profiling reveals alternative polyadenylation of mRNA in human non-small cell lung cancer

Journal of Translational Medicine, 2019
Background Lung cancer is the second most common cancer with an extremely poor overall survival rate. Post-transcriptional regulation of gene expression play many important roles in human cancer, and one of the potential mechanisms underlying this is ...
Shirong Zhang, Xiaochen Zhang, Wei Lei, Jiafeng Liang, Yasi Xu, Hailiang Liu, Shenglin Ma   +6 more
doaj   +1 more source

Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN

FEBS Open Bio, 2022
The 24‐h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate‐limiting step that determines the lifespan of a mRNA and is catalyzed by deadenylases ...
Rafailia A. A. Beta, Athanasios Kyritsis, Veroniki Douka, Eirini Papanastasi, Marianna Rizouli, Demetres D. Leonidas, Dimitrios Vlachakis, Nikolaos A. A. Balatsos   +7 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Zika Virus Infection Alters Gene Expression and Poly-Adenylation Patterns in Placental Cells

Pathogens, 2022
Flaviviruses are small RNA viruses that are mainly transmitted via arthropod vectors and are found in tropic and sub-tropical regions. Most infections are asymptomatic (90–95%), but symptoms can be as severe as hemorrhagic fever and encephalitis.
Stephanea L. Sotcheff, John Yun-Chung Chen, Nathan Elrod, Jun Cao, Elizabeth Jaworski, Mugé N. Kuyumcu-Martinez, Pei-Yong Shi, Andrew L. Routh   +7 more
doaj   +1 more source

Poly(A): Possible Role in Translation of Poly(A)-Rich RNA

Experimental Biology and Medicine, 1973
A covalently linked region, 100–200 nucleotides long, rich in polyriboadenylic acid [poly(A)], has been identified in rapidly labeled polyribosome-associated RNA and heterogeneous nuclear RNA in a number of eukaryotic cells (1–3), in several specific eukaryotic mRNAs (4–6), and in viral mRNAs (7).
M G, Rosenfeld, I B, Abrass, J, Mendelsohn, H I, Miller, J, Holland   +4 more
openaire   +2 more sources

High surface area, emulsion-templated carbon foams by activation of polyHIPEs derived from Pickering emulsions. [PDF]

, 2016
Carbon foams displaying hierarchical porosity and excellent surface areas of >1400 m2/g can be produced by the activation of macroporous poly(divinylbenzene).
Bismarck, A, De Luca, F, Roberts, AD, Woodward, RT   +3 more
core   +2 more sources