Results 61 to 70 of about 283,934 (290)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation

Nature Communications, 2016
BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 ...
Benjamin Stupfler, Catherine Birck, Bertrand Séraphin, Fabienne Mauxion   +3 more
doaj   +1 more source

Charge Carrier Concentration and Temperature Dependent Recombination in Polymer Fullerene Solar Cells

, 2009
We performed temperature dependent transient photovoltage and photocurrent measurements on poly(3-hexylthiophene):[6,6]-phenyl-C61 butyric acid methylester bulk heterojuction solar cells.
Baumann, A., Deibel, C., Dyakonov, V., Foertig, A., Rauh, D.   +4 more
core   +1 more source

The electric and magnetic form factors of the proton [PDF]

, 2013
The paper describes a precise measurement of electron scattering off the proton at momentum transfers of $0.003 \lesssim Q^2 \lesssim 1$\ GeV$^2$. The average point-to-point error of the cross sections in this experiment is $\sim$ 0.37%.
A. Esser, B. S. Schlimme, C. Ayerbe Gayoso, D. Bosnar, D. G. Middleton, H. Fonvieille, H. Merkel, J. Friedrich, J. Pochodzalla, J. C. Bernauer, J. M. Friedrich, L. Debenjak, L. Doria, L. Nungesser, M. Gómez Rodríguez de la Paz, M. Makek, M. Potokar, M. Weinriefer, M. O. Distler, null null, P. Achenbach, R. Böhm, S. Sánchez Majos, S. Širca, Th. Walcher, U. Müller   +25 more
core   +4 more sources

A potential link between transgene silencing and poly(A) tails [PDF]

RNA, 2005
Argonaute proteins function in gene silencing induced by double-stranded RNA (dsRNA) in various organisms. In Drosophila, the Argonaute proteins AGO1 and AGO2 have been implicated in post-transcriptional gene-silencing (PTGS)/RNA interference (RNAi). In this study, we found that AGO1 and AGO2 depletion caused the accumulation of multicopied enhanced ...
Mikiko C, Siomi, Hiroko, Tsukumo, Akira, Ishizuka, Tomoko, Nagami, Haruhiko, Siomi   +4 more
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails [PDF]

, 2012
The MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) locus is misregulated in many human cancers and produces an abundant long nuclear-retained noncoding RNA. Despite being transcribed by RNA polymerase II, the 3' end of MALAT1 is produced
Jnbaptiste, C. K., Joshua-Tor, L., Kuhn, C. D., Lu, L. Y., Sharp, P. A., Wilusz, J. E.   +5 more
core   +1 more source

Evidence that Poly(A) Binding Protein C1 Binds Nuclear Pre-mRNA Poly(A) Tails [PDF]

Molecular and Cellular Biology, 2006
In mammalian cells, poly(A) binding protein C1 (PABP C1) has well-known roles in mRNA translation and decay in the cytoplasm. However, PABPC1 also shuttles in and out of the nucleus, and its nuclear function is unknown. Here, we show that PABPC1, like the major nuclear poly(A) binding protein PABPN1, associates with nuclear pre-mRNAs that are ...
Nao, Hosoda, Fabrice, Lejeune, Lynne E, Maquat   +2 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RNA Unwinding by the Trf4/Air2/Mtr4 Polyadenylation (TRAMP) Complex [PDF]

, 2012
Many RNA-processing events in the cell nucleus involve the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex, which contains the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.
Anderson, James T., Jankowsky, Eckhard, Jia, Huijue, Wang, Xuying   +3 more
core   +2 more sources