Results 41 to 50 of about 285,813 (286)
Poly(A)-tail profiling reveals an embryonic switch in translational control [PDF]
, 2013 Poly(A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but difficulties in globally measuring poly(A)-tail lengths have impeded greater understanding of poly(A)-tail function. Here we describe poly(A)-tail length profiling
Bartel, David +4 more
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TED-Seq Identifies the Dynamics of Poly(A) Length during ER Stress
Cell Reports, 2018 Summary: Post-transcriptional RNA processing is a core mechanism of gene expression control in cell stress response. The poly(A) tail influences mRNA translation and stability, but it is unclear whether there are global roles of poly(A)-tail lengths in ...
Yu Mi Woo +6 more
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Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. [PDF]
PLoS Biology, 2013 Translation control often operates via remodeling of messenger ribonucleoprotein particles. The poly(A) binding protein (PABP) simultaneously interacts with the 3' poly(A) tail of the mRNA and the eukaryotic translation initiation factor 4G (eIF4G) to ...
Yuri V Svitkin +8 more
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CNOT6 regulates a novel pattern of mRNA deadenylation during oocyte meiotic maturation
Scientific Reports, 2018 In many cell types, the length of the poly(A) tail of an mRNA is closely linked to its fate - a long tail is associated with active translation, a short tail with silencing and degradation. During mammalian oocyte development, two contrasting patterns of
Karl-Frédéric Vieux, Hugh J. Clarke
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eLife, 2016 Because maturing oocytes and early embryos lack appreciable transcription, posttranscriptional regulatory processes control their development. To better understand this control, we profiled translational efficiencies and poly(A)-tail lengths throughout ...
Stephen W Eichhorn +5 more
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Poly(a) selection introduces bias and undue noise in direct RNA-sequencing
BMC Genomics, 2022 Background Genome-wide RNA-sequencing technologies are increasingly critical to a wide variety of diagnostic and research applications. RNA-seq users often first enrich for mRNA, with the most popular enrichment method being poly(A) selection.
Marcus J. Viscardi, Joshua A. Arribere
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Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites. [PDF]
, 2011 Our work on targeting redox equilibria of malarial parasites propagating in red blood cells has led to the selection of six 1,4-naphthoquinones, which are active at nanomolar concentrations against the human pathogen Plasmodium falciparum in culture and ...
Bauer, Holger +12 more
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Virology, 2014 Here we show that Tobacco mosaic virus (TMV), a positive-strand RNA virus known to end with 3׳ tRNA-like structures, does possess a small fraction of gRNA bearing polyadenylate tails. Particularly, many tails are at sites corresponding to the 3׳ end of near full length gRNA, and are composed of poly(A)-rich sequences containing the other nucleotides in
Li, Weimin +5 more
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FEBS Open Bio, 2022 The 24‐h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate‐limiting step that determines the lifespan of a mRNA and is catalyzed by deadenylases ...
Rafailia A. A. Beta +7 more
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On space efficiency of algorithms working on structural decompositions of graphs [PDF]
, 2016 Dynamic programming on path and tree decompositions of graphs is a technique that is ubiquitous in the field of parameterized and exponential-time algorithms.
Pilipczuk, Michał, Wrochna, Marcin
core +2 more sources