Results 21 to 30 of about 285,813 (286)
Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail [PDF]
Scientific Reports, 2018 AbstractEukaryotic mature mRNAs possess a poly adenylate tail (poly(A)), to which multiple molecules of poly(A)-binding protein C1 (PABPC1) bind. PABPC1 regulates translation and mRNA metabolism by binding to regulatory proteins. To understand functional mechanism of the regulatory proteins, it is necessary to reveal how multiple molecules of PABPC1 ...
Ryoichi Sawazaki +8 more
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RNA stabilization by a poly(A) tail 3'-end binding pocket and other modes of poly(A)-RNA interaction. [PDF]
Science, 2021 Torabi SF +7 more
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Dynamic RNA 3′ Uridylation and Guanylation during Mitosis
iScience, 2020 Summary: Successful cell division involves highly regulated transcriptional and post-transcriptional control. The RNA poly(A) tail represents an important layer of RNA post-transcriptional regulation.
Yusheng Liu, Hu Nie, Falong Lu
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RNA polyadenylation sites on the genomes of microorganisms, animals, and plants. [PDF]
PLoS ONE, 2013 Pre-messenger RNA (mRNA) 3'-end cleavage and subsequent polyadenylation strongly regulate gene expression. In comparison with the upstream or downstream motifs, relatively little is known about the feature differences of polyadenylation [poly(A)] sites ...
Xiu-Qing Li, Donglei Du
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eLife, 2020 La-related protein 4 (LARP4) directly binds both poly(A) and poly(A)-binding protein (PABP). LARP4 was shown to promote poly(A) tail (PAT) lengthening and stabilization of individual mRNAs presumably by protection from deadenylation (Mattijssen et al ...
Sandy Mattijssen +4 more
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Tales of Detailed Poly(A) Tails [PDF]
Trends in Cell Biology, 2019 Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stability of the mRNA.
Nicholson, Angela L, Pasquinelli, Amy E
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Polyadenylated tail length variation pattern in ultra-rapid vitrified bovine oocytes [PDF]
Veterinary World, 2016 Aim: The current study aims at investigating the polyadenylated (poly[A]) tail length of morphologically high and low competent oocytes at different developmental stages.
D. J. Dutta, Himangshu Raj, Hiramoni Dev
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East of EDEN was a poly(A) tail [PDF]
Biology of the Cell, 2003 AbstractPost‐transcriptional regulations of gene expression (control of mRNA stability and translation) play a central role in achieving cellular functions. In a large number of cases, post‐transcriptional regulations are dependent on mRNA poly(A) tails, as mRNAs with a long poly(A) tail are generally much more stable and actively translated than ...
Paillard, Luc, Osborne, H Beverley
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Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]
, 2020 Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J. +8 more
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Poly(A) Tail Shortening by a Mammalian Poly(A)-specific 3′-Exoribonuclease [PDF]
Journal of Biological Chemistry, 1997 3'-Exonucleolytic removal of the poly(A) tail is the first and often rate-limiting step in the decay of many eucaryotic mRNAs. In a cytoplasmic extract from HeLa cells, the poly(A) tail of mRNA was degraded from the 3'-end. In agreement with earlier in vivo observations, prominent decay intermediates differed in length by about 30 nucleotides. The Mg2+-
C G, Körner, E, Wahle
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