Results 21 to 30 of about 114,953,758 (241)
eLife, 2019 The Ccr4-Not complex removes mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood.
Michael W Webster +2 more
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Frontiers in Microbiology, 2018 The duck hepatitis A virus type 1 (DHAV-1) is a member of Picornaviridae family, the genome of the virus contains a 5′ untranslated region (5′ UTR), a large open reading frame that encodes a polyprotein precursor and a 3′ UTR followed by a poly(A) tail ...
Jun-Hao Chen +18 more
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The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes
Genome Biology, 2017 Background All mRNAs are bound in vivo by proteins to form mRNA–protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored. Here, we have analyzed, on a transcriptome-wide scale, how
Olivia S. Rissland +9 more
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Poly A- transcripts expressed in HeLa cells. [PDF]
PLoS ONE, 2008 Transcripts expressed in eukaryotes are classified as poly A+ transcripts or poly A- transcripts based on the presence or absence of the 3' poly A tail.
Qingfa Wu +9 more
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Cytoplasmic deadenylase Ccr4 is required for translational repression of LRG1 mRNA in the stationary phase. [PDF]
PLoS ONE, 2017 Ccr4 is a major cytoplasmic deadenylase involved in mRNA poly(A) tail shortening in Saccharomyces cerevisiae. We have previously shown that Ccr4 negatively regulates expression of LRG1 mRNA encoding a GTPase-activating protein for the small GTPase Rho1 ...
Duong Long Duy +2 more
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Oppositional poly(A) tail length regulation by FMRP and CPEB1. [PDF]
RNA, 2022 Poly(A) tail length is regulated in both the nucleus and cytoplasm. One factor that controls polyadenylation in the cytoplasm is CPEB1, an RNA binding protein that associates with specific mRNA 3'UTR sequences to tether enzymes that add and remove poly(A)
Shin J +7 more
europepmc +2 more sources
Individual piglets' contribution to the development of tail biting [PDF]
, 2011 Conflicting hypotheses exist about the contribution of individual pigs to the development of a tail-biting outbreak, but there is limited quantitative information to support or dismiss them.
Kemp, B. +4 more
core +1 more source
CNOT6 regulates a novel pattern of mRNA deadenylation during oocyte meiotic maturation
Scientific Reports, 2018 In many cell types, the length of the poly(A) tail of an mRNA is closely linked to its fate - a long tail is associated with active translation, a short tail with silencing and degradation. During mammalian oocyte development, two contrasting patterns of
Karl-Frédéric Vieux, Hugh J. Clarke
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TED-Seq Identifies the Dynamics of Poly(A) Length during ER Stress
Cell Reports, 2018 Summary: Post-transcriptional RNA processing is a core mechanism of gene expression control in cell stress response. The poly(A) tail influences mRNA translation and stability, but it is unclear whether there are global roles of poly(A)-tail lengths in ...
Yu Mi Woo +6 more
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eLife, 2016 Because maturing oocytes and early embryos lack appreciable transcription, posttranscriptional regulatory processes control their development. To better understand this control, we profiled translational efficiencies and poly(A)-tail lengths throughout ...
Stephen W Eichhorn +5 more
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