Results 21 to 30 of about 123,331 (250)
Polyadenylated tail length variation pattern in ultra-rapid vitrified bovine oocytes [PDF]
Veterinary World, 2016 Aim: The current study aims at investigating the polyadenylated (poly[A]) tail length of morphologically high and low competent oocytes at different developmental stages.
D. J. Dutta, Himangshu Raj, Hiramoni Dev
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Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus Polyadenylation. [PDF]
PLoS ONE, 2016 Similar to eukaryotic mRNA, the positive-strand coronavirus genome of ~30 kilobases is 5'-capped and 3'-polyadenylated. It has been demonstrated that the length of the coronaviral poly(A) tail is not static but regulated during infection; however, little
Yu-Hui Peng +5 more
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eLife, 2019 The Ccr4-Not complex removes mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood.
Michael W Webster +2 more
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Poly(A) Tail Shortening by a Mammalian Poly(A)-specific 3′-Exoribonuclease [PDF]
Journal of Biological Chemistry, 1997 3'-Exonucleolytic removal of the poly(A) tail is the first and often rate-limiting step in the decay of many eucaryotic mRNAs. In a cytoplasmic extract from HeLa cells, the poly(A) tail of mRNA was degraded from the 3'-end. In agreement with earlier in vivo observations, prominent decay intermediates differed in length by about 30 nucleotides. The Mg2+-
C G, Körner, E, Wahle
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Poly A- transcripts expressed in HeLa cells. [PDF]
PLoS ONE, 2008 Transcripts expressed in eukaryotes are classified as poly A+ transcripts or poly A- transcripts based on the presence or absence of the 3' poly A tail.
Qingfa Wu +9 more
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The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes
Genome Biology, 2017 Background All mRNAs are bound in vivo by proteins to form mRNA–protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored. Here, we have analyzed, on a transcriptome-wide scale, how
Olivia S. Rissland +9 more
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Cytoplasmic deadenylase Ccr4 is required for translational repression of LRG1 mRNA in the stationary phase. [PDF]
PLoS ONE, 2017 Ccr4 is a major cytoplasmic deadenylase involved in mRNA poly(A) tail shortening in Saccharomyces cerevisiae. We have previously shown that Ccr4 negatively regulates expression of LRG1 mRNA encoding a GTPase-activating protein for the small GTPase Rho1 ...
Duong Long Duy +2 more
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Cap homeostasis is independent of poly(A) tail length [PDF]
Nucleic Acids Research, 2015 Cap homeostasis is a cyclical process of decapping and recapping that maintains the cap on a subset of the cytoplasmic transcriptome. Interfering with cytoplasmic capping results in the redistribution of target transcripts from polysomes to non-translating mRNPs, where they accumulate in an uncapped but nonetheless stable form.
Kiss, Daniel L. +5 more
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CNOT6 regulates a novel pattern of mRNA deadenylation during oocyte meiotic maturation
Scientific Reports, 2018 In many cell types, the length of the poly(A) tail of an mRNA is closely linked to its fate - a long tail is associated with active translation, a short tail with silencing and degradation. During mammalian oocyte development, two contrasting patterns of
Karl-Frédéric Vieux, Hugh J. Clarke
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TED-Seq Identifies the Dynamics of Poly(A) Length during ER Stress
Cell Reports, 2018 Summary: Post-transcriptional RNA processing is a core mechanism of gene expression control in cell stress response. The poly(A) tail influences mRNA translation and stability, but it is unclear whether there are global roles of poly(A)-tail lengths in ...
Yu Mi Woo +6 more
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