Results 11 to 20 of about 123,331 (250)
MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA [PDF]
Nature CommunicationsThe mammalian early embryo development requires translation of maternal mRNA inherited from the oocyte. While poly(A) tail length influences mRNA translation efficiency during the oocyte-to-embryo transition (OET), molecular mechanisms regulating ...
Jing Yang +8 more
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PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility [PDF]
Nature CommunicationsIn oocytes of mammals and other animals, gene regulation is mediated primarily through changes in poly(A)-tail length. Here, we introduce PAL-AI, an integrated neural network machine-learning model that accurately predicts tail-length changes in maturing
Kehui Xiang, David P. Bartel
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Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail [PDF]
Scientific Reports, 2018 Eukaryotic mature mRNAs possess a poly adenylate tail (poly(A)), to which multiple molecules of poly(A)-binding protein C1 (PABPC1) bind. PABPC1 regulates translation and mRNA metabolism by binding to regulatory proteins.
Ryoichi Sawazaki +8 more
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The molecular basis of coupling between poly(A)-tail length and translational efficiency [PDF]
eLife, 2021 In animal oocytes and early embryos, mRNA poly(A)-tail length strongly influences translational efficiency (TE), but later in development this coupling between tail length and TE disappears.
Kehui Xiang, David P Bartel
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Dynamic RNA 3′ Uridylation and Guanylation during Mitosis
iScience, 2020 Summary: Successful cell division involves highly regulated transcriptional and post-transcriptional control. The RNA poly(A) tail represents an important layer of RNA post-transcriptional regulation.
Yusheng Liu, Hu Nie, Falong Lu
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RNA polyadenylation sites on the genomes of microorganisms, animals, and plants. [PDF]
PLoS ONE, 2013 Pre-messenger RNA (mRNA) 3'-end cleavage and subsequent polyadenylation strongly regulate gene expression. In comparison with the upstream or downstream motifs, relatively little is known about the feature differences of polyadenylation [poly(A)] sites ...
Xiu-Qing Li, Donglei Du
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eLife, 2020 La-related protein 4 (LARP4) directly binds both poly(A) and poly(A)-binding protein (PABP). LARP4 was shown to promote poly(A) tail (PAT) lengthening and stabilization of individual mRNAs presumably by protection from deadenylation (Mattijssen et al ...
Sandy Mattijssen +4 more
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Regulation of coronaviral poly(A) tail length during infection. [PDF]
PLoS ONE, 2013 The positive-strand coronavirus genome of ~30 kilobase in length and subgenomic (sg) mRNAs of shorter lengths, are 5' and 3'-co-terminal by virtue of a common 5'-capped leader and a common 3'-polyadenylated untranslated region.
Hung-Yi Wu +3 more
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East of EDEN was a poly(A) tail [PDF]
Biology of the Cell, 2003 AbstractPost‐transcriptional regulations of gene expression (control of mRNA stability and translation) play a central role in achieving cellular functions. In a large number of cases, post‐transcriptional regulations are dependent on mRNA poly(A) tails, as mRNAs with a long poly(A) tail are generally much more stable and actively translated than ...
Paillard, Luc, Osborne, H Beverley
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Tales of Detailed Poly(A) Tails [PDF]
Trends in Cell Biology, 2019 Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stability of the mRNA.
Nicholson, Angela L, Pasquinelli, Amy E
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