Results 61 to 70 of about 123,331 (250)
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Role of poly(A) tail length in Alu retrotransposition
Genomics, 2005 Alu are mobile noncoding Short INterspersed Elements (SINEs) present at a million copies in the human genome. Using marked Alu sequences in an ex vivo assay, we previously showed that they are mobilized through diversion of the LINE (Long INterspersed Elements) retrotransposition machinery, with the poly(A) tail of the Alu being required for their ...
Marie, Dewannieux, Thierry, Heidmann
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Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Cathodic Cage Plasma Deposition of Nanostructured Cu–Fe–Se Coatings on Poly(methyl Methacrylate)
Advanced Engineering Materials, EarlyView.Nanostructured Cu–Fe–Se coatings are deposited on PMMA by a modified cathodic cage plasma process, enabling low‐temperature deposition on polymer substrates. A transition from discontinuous to compact morphology is observed with temperature, with optimal properties at 200°C, where improved CuFeSe2‐type bonding, lowest sheet resistance, and favorable ...
V. S. S. Sobrinho +8 more
wiley +1 more source
Pan-organ poly(A) atlas reveals a post-transcriptional regulatory layer independent of RNA abundance
Nature CommunicationsPost-transcriptional regulation via the mRNA poly(A) tail is fundamental to gene expression, yet a comprehensive dataset across an entire organism is still lacking.
Huajie Lei +17 more
doaj +1 more source
Translation of poly(A) tails leads to precise mRNA cleavage [PDF]
RNA, 2017 Translation of poly(A) tails leads to mRNA cleavage but the mechanism and global pervasiveness of this “nonstop/no-go” decay process is not understood. Here we performed ribosome profiling (in a yeast strain lacking exosome function) of short 15–18 nucleotides mRNA footprints to identify ribosomes stalled at 3′ ends of mRNA decay intermediates. In this
Nicholas R. Guydosh, Rachel Green
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Advanced Engineering Materials, EarlyView.This article presents an experimental and numerical modal investigation of composite sandwich structures using surfboards as model systems. By comparing different core materials and reinforcement strategies, the study demonstrates how local stiffeners influence vibrational response and introduce characteristic modal features, highlighting modal ...
Brett Connellan +4 more
wiley +1 more source
Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression.
PLoS Computational Biology, 2020 The mammalian circadian clock is deeply rooted in rhythmic regulation of gene expression. Rhythmic transcriptional control mediated by the circadian transcription factors is thought to be the main driver of mammalian circadian gene expression.
Xiangyu Yao, Shihoko Kojima, Jing Chen
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A maternal tail of poly(a): The long and the short of it
Cell, 1992 Rosemary F. Bachvarova Department of Cell Biology Cornell University Medical College New York, New York 10021 Just as most cells transcribe only some of their many genes, so growing oocytes, maturing oocytes, and early embryos translate only some of the many messages pres- ent in the cytoplasm.
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From Food to Power: Hydrogel Thermoelectrics for Ingestible Electronics
Advanced Functional Materials, EarlyView.We introduce a fully edible thermoelectric–electrochromic platform that harvests heat from food and converts it into a visible color change. N‐type and p‐type hydrogel thermoelectric generators connected in series power anthocyanin‐based electrochromic displays, demonstrating the feasibility of safe, biodegradable, ingestible systems for on‐food ...
Antonia Georgopoulou +3 more
wiley +1 more source