Results 51 to 60 of about 285,813 (286)
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes. [PDF]
PLoS ONE, 2014 Maternal effect genes code for oocyte proteins that are important for early embryogenesis. Transcription in oocytes does not take place from the onset of meiotic progression until zygotic genome activation.
Debora Dankert +7 more
doaj +1 more source
A kingdom-wide full-length RNA atlas reveals the evolutionary landscapes of plant poly(A) tails
Genome BiologyBackground Poly(A) tails play crucial roles in regulating mRNA degradation and translation, yet their evolutionary dynamics remain largely unexplored. Results Here, we generate a comprehensive full-length RNA atlas of poly(A) tail based on 130 million ...
Yang Chen +17 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
mRNA poly(A) tail, a 3' enhancer of translational initiation. [PDF]
Molecular and Cellular Biology, 1990 To evaluate the hypothesis that the 3' poly(A) tract of mRNA plays a role in translational initiation, we constructed derivatives of pSP65 which direct the in vitro synthesis of mRNAs with different poly(A) tail lengths and compared, in reticulocyte extracts, the relative efficiencies with which such mRNAs were translated, degraded, recruited into ...
Munroe, David, Jacobson, Allan
openaire +4 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice
Nature Communications, 2023 In mammals, the production of mature oocytes necessitates rigorous regulation of the discontinuous meiotic cell-cycle progression at both the transcriptional and post-transcriptional levels. However, the factors underlying this sophisticated but explicit
Xue Jiang +14 more
doaj +1 more source
, 2009 We performed temperature dependent transient photovoltage and photocurrent measurements on poly(3-hexylthiophene):[6,6]-phenyl-C61 butyric acid methylester bulk heterojuction solar cells.
Baumann, A. +4 more
core +1 more source
Polynomial bounds for decoupling, with applications [PDF]
, 2015 Let f(x) = f(x_1, ..., x_n) = \sum_{|S|
O'Donnell, Ryan, Zhao, Yu
core +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source