Results 101 to 110 of about 15,767 (251)

Double‐Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration

Aging Cell, Volume 25, Issue 4, April 2026.
A novel drug combination (NMN + API) promotes musculoskeletal regeneration in aging. By boosting NAD+, it activates SIRT3 to suppress cellular senescence and enhance differentiation into chondrocytes, osteoblasts, and myocytes. Oral administration reshapes the gut microbiota, increasing production of the anti‐aging metabolite PHS.
Jianfeng Yu, Mingzhuang Hou, Yaoge Deng, Chenqi Yu, Yang Liu, Kang Kang, Xiaowei Xia, Xiaoping Li, Huilin Yang, Dinghua Jiang, Wu Xu, Yijian Zhang, Xuesong Zhu   +12 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, Volume 158, Issue 6, Page 1617-1627, 15 March 2026.
What's new? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

Organic and Metallacages for Chemical Sensing: Progress in Water‐Compatible Systems

Advanced Sensor Research, Volume 5, Issue 3, March 2026.
Supramolecular cages function as three‐dimensional receptors for selective molecular recognition and sensing, and this review outlines design principles for water‐stable architectures, key analyte‐ and medium‐dependent challenges, recent water‐compatible examples (including polymer‐integrated systems), and future opportunities for cage‐based ...
Rabia Zahid, Martina Viola, Maria Vittoria Balli, Guillermo Moreno‐Alcántar, Pierre Picchetti   +4 more
wiley   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, Volume 117, Issue 3, Page 587-596, March 2026.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

NAD+ Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
JEV infection in brain tissue triggers inflammation and stress in neuronal cells, leading to NAD+ depletion via the overactivation of PARPs and SIRTs. While compensatory biosynthetic pathways (de novo and salvage) were upregulated, the NAD+ level fell critically. In vitro NAMPT inhibition exacerbates this deficit and viral load.
Takele Adugna Kassegn, Zhancheng Tian, Junzheng Du, Qingli Niu, Jifei Yang, Zhang Hongge, Yuqing Song, Fengxue Chai, Zhonghui Zhang, Guiquan Guan, Hong Yin   +10 more
wiley   +1 more source

PARP Inhibitors in Biliary Tract Cancer: A New Kid on the Block?

Medicines, 2020
Poly adenosine diphosphate-ribose polymerase inhibitors (PARPi) represent an effective therapeutic strategy for cancer patients harboring germline and somatic aberrations in DNA damage repair (DDR) genes.
Angela Dalia Ricci, Alessandro Rizzo, Chiara Bonucci, Nastassja Tober, Andrea Palloni, Veronica Mollica, Ilaria Maggio, Marzia Deserti, Simona Tavolari, Giovanni Brandi   +9 more
doaj   +1 more source

A systematic analysis of the PARP protein family identifies new functions critical for cell physiology [PDF]

, 2013
The poly(ADP-ribose) polymerase (PARP) family of proteins use NAD[superscript +] as their substrate to modify acceptor proteins with ADP-ribose modifications. The function of most PARPs under physiological conditions is unknown.
Chang, Paul, Chesarone-Cataldo, Melissa, Huang, Yun-Han, Todorova, Tanya, Vyas, Sejal   +4 more
core   +1 more source

From mechanism to phenotype: What fits in a basket trial

Epilepsia, Volume 67, Issue 4, Page 1573-1581, April 2026.
Kette D. Valente
wiley   +1 more source