Results 101 to 110 of about 657,615 (203)

Do Not Forget Poly (Adenosine Diphosphate-Ribose) Polymerase Inhibitors in Ovarian Carcinosarcoma. [PDF]

Cureus, 2022
Magalhães D, Bartosch C, Abreu MH.
europepmc   +1 more source

7-Deaza cyclic adenosine 5′-diphosphate ribose: first example of a Ca2+-mobilizing partial agonist related to cyclic adenosine 5′-diphosphate ribose [PDF]

, 1997
Background: Cyclic adenosine 5′-diphosphate ribose (cADPR), a naturally occurring metabolite of nicotinamide adenine dinucleotide (NAD+), mobilizes Ca2+ from non-mitochondria' stores in a variety of mammalian and invertebrate tissues.
Jaswinder K. Sethi, Fortt, Simon M., Simon M. Fortt, Antony Galione, Bailey, Victoria C., Potter, Barry V.L., Barry V.L. Potter, Sethi, Jaswinder K., Victoria C. Bailey, Galione, Antony   +9 more
core   +1 more source

Programmed death ligand 1, poly adenosine diphosphate ribose polymerase, and vascular endothelial growth factor receptor inhibition: a potential combination regimen for targeting triple-negative breast cancer? [PDF]

Int J Surg, 2023
Abdul Wahid M, Hussain HU, Ghouri H, Khan T, Rehan ST, Mumtaz H.   +5 more
europepmc   +1 more source

Total Synthesis of a Cyclic Adenosine 5′-Diphosphate Ribose Receptor Agonist

, 2015
Stable cyclic adenosine 5′-diphosphate ribose (cADPR) analogues are chemical biology tools that can probe the Ca2+ release mechanism and structure–activity relationships of this emerging potent second messenger.
Joanna M. Swarbrick (1285617), Barry V. L. Potter (286876)   +1 more
core   +1 more source

Prospects for non-immunological molecular therapeutics in melanoma [PDF]

, 2010
In 2006 there were 60,000 new cases of cutaneous melanoma in the European Union and 13,000 deaths (www.europeancancerleagues.org). Currently available systemic treatment options for metastatic melanoma, including both cytotoxic and immunologic therapies,
Tryfonopoulos, Dimitrios, Eustace, Alexander J., Mahgoub, Thamir, O\u27Donovan, Norma, Crown, John, O'Donovan, Norma   +5 more
core   +2 more sources

Rapid Synthetic Route toward Structurally Modified Derivatives of Cyclic Adenosine 5‘-Diphosphate Ribose

, 2016
A concise synthesis of five new analogues of the second messenger cADPR (cyclic adenosine 5‘-diphosphate ribose) is presented. The synthetic plan centered around the key derivative 8-Br-N1-cIDPR (cyclic 8-Br-inosine 5‘-diphosphate ribose, 2), which was ...
Gerd K. Wagner (423554), Barry V. L. Potter (286876), Andreas H. Guse (78011)   +2 more
core   +1 more source

Complete response to olaparib in a patient with metastatic pancreatic cancer harboring a germline BRCA2 mutation

Oncology in Clinical Practice
Metastatic pancreatic cancer (mPC) is usually diagnosed at an advanced stage, and systemic therapy is still the main treatment option. Pathological germline mutations in the BRCA1 or BRCA2 genes are present in aroun 4–7% of cases of pancreatic cancer (PC)
Agata I. Adamczuk-Nurzyńska, Paweł Nurzyński, Artur Sankowski   +2 more
doaj   +1 more source

Accumulation of poly (adenosine diphosphate-ribose) by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells. [PDF]

World J Gastroenterol, 2022
Jeong KY, Sim JJ, Park M, Kim HM.
europepmc   +1 more source

Inositol Trisphosphate and Cyclic Adenosine Diphosphate-Ribose Increase Quantal Transmitter Release at Frog Motor Nerve Terminals: Possible Involvement of Smooth Endoplasmic Reticulum

, 1999
The release of chemical transmitter from nerve terminals is critically dependent on a transient increase in intracellular Ca2+.6,25 The increase in Ca2+ may be due to influx of Ca2+ from the extracellular fluid15 or release of Ca2+ from intracellular ...
Miyamoto, M. D., Brailoiu, E.
core   +1 more source

Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications

Neural Regeneration Research
For diverse neurodegenerative disorders, microglial cells are activated. Furthermore, dysfunctional and hyperactivated microglia initiate mitochondrial autophagy, oxidative stress, and pathological protein accumulation, ending with neuroinflammation that
Wenhui Zhao, Zhongxuan Liu, Jiannan Wu, Anran Liu, Junqiang Yan   +4 more
doaj   +1 more source