Results 81 to 90 of about 7,605 (170)

Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications

Neural Regeneration Research
For diverse neurodegenerative disorders, microglial cells are activated. Furthermore, dysfunctional and hyperactivated microglia initiate mitochondrial autophagy, oxidative stress, and pathological protein accumulation, ending with neuroinflammation that
Wenhui Zhao, Zhongxuan Liu, Jiannan Wu, Anran Liu, Junqiang Yan   +4 more
doaj   +1 more source

Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted ¹⁸F-Fluorthanatrace PET Images of Ovarian Cancer. [PDF]

J Nucl Med, 2022
Young AJ, Pantel AR, Viswanath V, Dominguez TL, Makvandi M, Lee H, Li S, Schubert EK, Pryma DA, Farwell MD, Mach RH, Simpkins F, Lin LL, Mankoff DA, Doot RK.   +14 more
europepmc   +1 more source

Poly(adenosine diphosphate ribose) Synthesis in Soluble Extracts of Animal Organs

Journal of Biological Chemistry, 1972
Abstract Poly(adenosine diphosphate ribose) (poly(ADP-ribose)) which is normally synthesized in chromatin is also synthesized from NAD by soluble extracts of animal organs prepared in 0.5 m NaCl, KCl, or NH4Cl. Extracts of thymus, bone marrow, lymph nodes, and spleen are the most active.
openaire   +2 more sources

Patient cost sharing during poly(adenosine diphosphate-ribose) polymerase inhibitor treatment in ovarian cancer. [PDF]

Am J Obstet Gynecol, 2021
Harrison RF, Fu S, Sun CC, Zhao H, Lu KH, Giordano SH, Meyer LA.   +6 more
europepmc   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Studies on Poly (Adenosine Diphosphate Ribose)

Journal of Biological Chemistry, 1970
Hirotaka Matsubara, Shuji Hasegawa, Shinji Fujimura, Teruo Shima, Takashi Sugimura, Masamitsu Futai   +5 more
openaire   +1 more source

PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease

MedComm
The poly(ADP‐ribose) polymerase (PARP) family consists of 17 members of nicotinamide adenine dinucleotide (NAD⁺)‐dependent enzymes that regulate key biological processes by catalyzing adenosine diphosphate (ADP)‐ribosylation, either poly(ADP‐ribosyl ...
Pengyuan Lei, Wenfeng Li, Jinhua Luo, Nanxin Xu, Yahe Wang, Dafei Xie, Hua Guan, Bo Huang, Xin Huang, Pingkun Zhou   +9 more
doaj   +1 more source

Progesterone Enhances Niraparib Efficacy in Ovarian Cancer by Promoting Palmitoleic-Acid-Mediated Ferroptosis

Research
Poly (adenosine 5′-diphosphate-ribose) polymerase inhibitors (PARPi) are increasingly important in the treatment of ovarian cancer. However, more than 40% of BRCA1/2-deficient patients do not respond to PARPi, and BRCA wild-type cases do not show obvious
Nayiyuan Wu, Xiu Zhang, Chao Fang, Miaochen Zhu, Zhibin Wang, Lian Jian, Weili Tan, Ying Wang, He Li, Xuemeng Xu, Yujuan Zhou, Tang-Yuan Chu, Jing Wang, Qianjin Liao   +13 more
doaj   +1 more source

Adenosine diphosphate-ribosylation greatly affects proteins function: a focus on neurodegenerative diseases

Frontiers in Aging Neuroscience
Adenosine diphosphate-ribosylation (ADPRylation) is a reversible posttranslational modification that plays a crucial role in cellular homeostasis and disease development.
Chaowen Huang, Huilin Xiao, Yang Yang, Jiankun Luo, Yixi Lai, Shizhen Liu, Kanmin Mao, Jialong Chen, Liling Wang   +8 more
doaj   +1 more source

Studies on Poly Adenosine Diphosphate-Ribose

Journal of Biological Chemistry, 1969
Teruo Shima, Shinji Fujimura, Shuji Hasegawa, Yoshiko Shimizu, Takashi Sugimura   +4 more
openaire   +1 more source