Results 71 to 80 of about 15,767 (251)

Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications [PDF]

, 2012
Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation ...
Jin, H, Yang, Z, Yu, P, Yue, J, Zhang, L, Zhang, L, Zhou, Y   +6 more
core   +2 more sources

PARP inhibition and immune modulation: scientific rationale and perspectives for the treatment of gynecologic cancers

Therapeutic Advances in Medical Oncology, 2020
Poly[adenosine diphosphate (ADP) ribose]polymerase (PARP) has multifaceted roles in the maintenance of genomic integrity, deoxyribonucleic acid (DNA) repair and replication, and the maintenance of immune-system homeostasis.
Elizabeth K. Lee, Panagiotis A. Konstantinopoulos   +1 more
doaj   +1 more source

Prostate cancer and PARP inhibitors: progress and challenges

Journal of Hematology & Oncology, 2021
Despite survival improvements achieved over the last two decades, prostate cancer remains lethal at the metastatic castration-resistant stage (mCRPC) and new therapeutic approaches are needed.
Diego Teyssonneau, Henri Margot, Mathilde Cabart, Mylène Anonnay, Paul Sargos, Nam-Son Vuong, Isabelle Soubeyran, Nicolas Sevenet, Guilhem Roubaud   +8 more
doaj   +1 more source

Inhibited effects of veliparib combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line [PDF]

, 2003
ObjectiveTo explore inhibition effects of veliparib as PARP inhibitor combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line.MethodsBEL-7404 was taken as the object of study and conventional culture was performed.
Yu, Bodley, Sunter, Rouleau, Ellisen, Chalmers, Porcelli, Isakoff, Corcuera, He, Hong, Pachkowski, Farmer, Bryant, Madison, Zhang, Balmañal, Zimmermann   +17 more
core   +1 more source

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs [PDF]

, 2018
Herein, we reported on the synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca2+-releasing secondary messenger that was firstly isolated from sea urchin eggs extracts.
Borbone, Nicola, Catalanotti, Bruno, Costantino, Valeria, D'Errico, Stefano, Mayol, Luciano, Oliviero, Giorgia, Pannaccione, Anna, Petrozziello, Tiziana, Piccialli, Gennaro, Piccialli, Ilaria, Secondo, Agnese   +10 more
core   +2 more sources

Bovine thymus poly(adenosine diphosphate ribose) polymerase.

Journal of Biological Chemistry, 1978
About 1,300-fold purification of poly(adenosine diphosphate ribose) polymerase has been achieved from the extract of bovine thymus with a recovery of 10 to 20%. The final preparation has a purity of 99%, and the enzyme is composed of a single peptide with a molecular weight of 130,000. The purified enzyme required NAD+, Mg2+, a thiol compound, DNA, and
K, Yoshihara, T, Hashida, Y, Tanaka, H, Ohgushi, H, Yoshihara, T, Kamiya   +5 more
openaire   +2 more sources

Guidance Statement On BRCA1/2 Tumor Testing in Ovarian Cancer Patients [PDF]

, 2017
International audienceThe approval, in 2015, of the first poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi; olaparib, Lynparza) for platinum-sensitive relapsed high-grade ovarian cancer with either germline or somatic BRCA1/2 deleterious ...
Banerjee, Susana, Bryce, Jane, Büttner, Reinhard, Capoluongo, Ettore, de Castro, David Gonzalez, Ellison, Gillian, Endris, Volker, Friedman, Eitan, Kamel-Reid, Suzanne, Ligtenberg, Marjolijn J L, Ligtenberg, Marjolijn J.L., López-Guerrero, José Antonio, Markiefka, Birgid, Penault-Llorca, Frédérique, Percival, Natalie, Ray-Coquard, Isabelle, Röthlisberger, Benno, Schirmacher, Peter, Singer, Christian, Soong, Richie, Van Asperen, Christi J, van Asperen, Christi J.   +21 more
core   +4 more sources

Demonstration of high molecular weight poly (adenosine diphosphate ribose)

Nucleic Acids Research, 1978
An electrophoretic system was established that resolves poly(adenosine diphosphate ribose), enzymatically synthesized polymer from NAD+, by size difference of one residue on polyacrylamide gel. The existence of a polymer of at least 65 residues was demonstrated by band counting in this system. The polymer showed a heterogeneous size distribution on the
M, Tanaka, K, Hayashi, H, Sakura, M, Miwa, T, Matsushima, T, Sugimura   +5 more
openaire   +3 more sources

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities [PDF]

, 2013
Poly-ADP-ribosylation is a post-translational modification that regulates processes involved in genome stability. Breakdown of the poly(ADP-ribose) (PAR) polymer is catalysed by poly(ADP-ribose) glycohydrolase (PARG), whose endo-glycohydrolase activity ...
Ahel, Ivan, Ahel, Marijan, Banos, Benito, Barkauskaite, Eva, Brassington, Amy, Dunstan, Mark S., Lafite, Pierre, Leys, David, Mitchison, Timothy J., Tan, Edwin S., Warwicker, Jim   +10 more
core   +2 more sources

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source