Results 51 to 60 of about 15,767 (251)

Defective DNA repair mechanisms in prostate cancer: impact of olaparib [PDF]

, 2017
The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects.
De Felice, Francesca, Marampon, Francesco, Marchetti, Claudia, Musella, Angela, Tombolini, Vincenzo   +4 more
core   +2 more sources

Two cases of CRPC with BRCA mutation treated by olaparib after favorable response to cisplatin

IJU Case Reports, 2023
Introduction Several prostate cancers carry homologous recombination repair mutations that respond to olaparib. Because of the mechanism, the efficacy of platinum‐based therapy can be used to predict the efficacy of poly(adenosine diphosphate‐ribose ...
Yoshiyuki Miyazawa, Takanori Shimizu, Yoshitaka Sekine, Seiji Arai, Akira Ohtsu, Yuji Fujizuka, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Kazuhiro Suzuki   +9 more
doaj   +1 more source

Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application [PDF]

Exploration of Drug Science
Pentafuranosylnucleos(t)ides represent a class of natural compounds regulating diverse cell functions being preferably components of biopolymers and also participating as cyclic regulatory low-molecular ligands.
Dmitrii Platov, Anna Kozlova, Cyril Alexeev, Mikhail Drenichev   +3 more
doaj   +1 more source

Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation. [PDF]

PLoS Biology, 2016
The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage.
Xin Sun, Kai Fu, Andrea Hodgson, Eric M Wier, Matthew G Wen, Olena Kamenyeva, Xue Xia, Lily Y Koo, Fengyi Wan   +8 more
doaj   +1 more source

A phase 1 study of ASTX727 plus talazoparib in patients with triple-negative or hormone resistant/HER2-negative metastatic breast cancer. [PDF]

Cancer
Abstract Background Poly(adenosine diphosphate ribose) polymerase (PARP) is recruited to DNA damage sites along with epigenetic factors such as DNA methyltransferase 1 (DNMT1). Inhibitors of DNMT modulate reactive oxygen species (ROS)‐cyclic adenosine monophosphate (cAMP)/Protein Kinase A signaling and induce a “BRCAness phenotype” that further ...
Miller KD, Thomas A, Althouse S, Zang Y, Conder E, Burgos R, Schneider BP, Ballinger T, Douglas E, Ansley K, Jang HJ, Chung W, Issa JP, Nephew KP, Rassool FV.   +14 more
europepmc   +2 more sources

Nucleotides: Structure and Properties [PDF]

, 2005
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core   +1 more source

Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region. [PDF]

, 2005
Summary The family of the poly(adenosine diphosphate-ribose) polymerase (PARP) proteins is directly involved in genomic stability, DNA repair, and apoptosis by DNA damage.
Argenziano G, Bianco AR, Carlomagno C, De Rosa G., Fabbrocini G, Lo Muzio L, Mascolo M, Molea G, Pepe S, Salvatore G, Scalvenzi M, Somma P, Staibano S   +12 more
core   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Complete response to orally administered melphalan in malignant pleural effusion from an occult female genital organ primary neoplasm with BRCA1/2 mutations: a case report

Journal of Medical Case Reports, 2018
Background Definite diagnosis of metastasis from unknown primary depends on a comprehensive immunohistochemical investigation of tumor specimen. Accurate identification of the origin site usually helps a lot in choosing the most appropriate treatment ...
Frank S. Fan, Chung-Fan Yang
doaj   +1 more source

Poly(ADP-ribose) potentiates ZAP antiviral activity.

PLoS Pathogens, 2022
Zinc-finger antiviral protein (ZAP), also known as poly(ADP-ribose) polymerase 13 (PARP13), is an antiviral factor that selectively targets viral RNA for degradation.
Guangai Xue, Klaudia Braczyk, Daniel Gonçalves-Carneiro, Daria M Dawidziak, Katarzyna Sanchez, Heley Ong, Yueping Wan, Kaneil K Zadrozny, Barbie K Ganser-Pornillos, Paul D Bieniasz, Owen Pornillos   +10 more
doaj   +1 more source