Results 41 to 50 of about 657,615 (203)
DNA damage during transplantation can activate poly-adenosine diphosphate ribose polymerase (PARP) resulting in the generation of polymers of adenosine diphosphate-ribose (PAR).
Brain JG, Rostron AJ, Kirby JA, Dark JH
core +5 more sources
Indian Journal of Medical and Paediatric Oncology, 2020 Poly(adenosine diphosphate ribose) polymerase inhibitors (PARPis), when used in patients harboring tumor with homologous recombination deficiency, with or without BRCA mutation, have shown favorable outcomes in relapsed, advanced metastatic breast and ...
Avinash Pandey, Joydeep Ghosh
doaj +1 more source
, 2002 Poly(adenosine 5'-diphosphate) ribose polymerase is a nuclear enzyme activated in response to genotoxic stress induced by a variety of DNA damaging agents.
Liaudet, L.
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PARP Inhibitors in First-Line Therapy of Ovarian Cancer: Are There Any Doubts?
Frontiers in Oncology, 2020 The standard of care for newly diagnosed advanced ovarian cancer (NADOC) is represented by surgical debulking followed by systemic platinum–taxanes combination chemotherapy.
Elisena Franzese +6 more
doaj +1 more source
Therapeutic Advances in Medical Oncology, 2020 Poly[adenosine diphosphate (ADP) ribose]polymerase (PARP) has multifaceted roles in the maintenance of genomic integrity, deoxyribonucleic acid (DNA) repair and replication, and the maintenance of immune-system homeostasis.
Elizabeth K. Lee +1 more
doaj +1 more source
Prostate cancer and PARP inhibitors: progress and challenges
Journal of Hematology & Oncology, 2021 Despite survival improvements achieved over the last two decades, prostate cancer remains lethal at the metastatic castration-resistant stage (mCRPC) and new therapeutic approaches are needed.
Diego Teyssonneau +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Homologous recombination DNA repair (HR) is a complex DNA damage repair pathway and an attractive target of inhibition in anti-cancer therapy. To help guide the development of efficient HR inhibitors, it is critical to identify compensatory HR sub ...
Platon Selemenakis +7 more
doaj +1 more source
Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase. [PDF]
Journal of Clinical Investigation, 1987 The chromatin-bound enzyme poly(ADP-ribose) polymerase (ADPRP) is strongly stimulated by DNA with single- or double-stranded breaks, and transfers the ADP-ribose moiety of NAD to nuclear proteins. The activation of ADPRP is important for DNA repair and replication, and also has been postulated to play a role in the pathogenesis of lymphocyte ...
H, Yamanaka +5 more
openaire +2 more sources
, 1983 The inter- and intracellular localization of poly(adenosine diphosphate-ribose)(poly(ADP-ribose] synthetase was investigated using an indirect immunofluorescence technique and a specific antibody against the enzyme purified from calf thymus.
K Ueda, K Ikai
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The evolving role of immunotherapy in ovarian cancer
Cancer, Volume 132, Issue 18, 15 September 2026.Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani +2 more
wiley +1 more source