Results 21 to 30 of about 7,599 (172)

Poly(adenosine diphosphate ribose) polymerase in Physarum polycephalum [PDF]

Biochemical Journal, 1975
1. The isolated nuclei of the slime mould Physarum polycephalum contain an enzyme that will incorporated [adenine-3H] NAD+ into an acid-insoluble product, which is shown to be poly(ADP-ribose). 2. This incorporation has an optimum pH of 8.2 and a temperature optimum below 10degreesC. 3. Optimum stimulation is given by 15 mM-Mg2+. 4.
M D, Brightwell, C E, Leech, M K, O'Farrell, W J, Whish, S, Shall   +4 more
openaire   +2 more sources

Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives. [PDF]

PLoS ONE, 2012
Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases.
Julie A Tucker, Neil Bennett, Claire Brassington, Stephen T Durant, Giles Hassall, Geoff Holdgate, Mark McAlister, J Willem M Nissink, Caroline Truman, Martin Watson   +9 more
doaj   +1 more source

Host cell poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle. [PDF]

PLoS ONE, 2013
Trypanosoma cruzi, etiological agent of Chagas' disease, has a complex life cycle which involves the invasion of mammalian host cells, differentiation and intracellular replication. Here we report the first insights into the biological role of a poly(ADP-
Salomé C Vilchez Larrea, Mariana Schlesinger, María L Kevorkian, Mirtha M Flawiá, Guillermo D Alonso, Silvia H Fernández Villamil   +5 more
doaj   +1 more source

Identification of PARP12 Inhibitors By Virtual Screening and Molecular Dynamics Simulations

Frontiers in Pharmacology, 2022
Poly [adenosine diphosphate (ADP)-ribose] polymerases (PARPs) are members of a family of 17 enzymes that performs several fundamental cellular processes.
Tahani M. Almeleebia, Shahzaib Ahamad, Irfan Ahmad, Ahmad Alshehri, Ali G. Alkhathami, Mohammad Y. Alshahrani, Mohammed A. Asiri, Amir Saeed, Amir Saeed, Jamshaid Ahmad Siddiqui, Dharmendra K. Yadav, Mohd Saeed   +11 more
doaj   +1 more source

Recurrent Cervical Cancer Treated Successfully with Single-Agent PARP-Inhibitor, Olaparib

Case Reports in Obstetrics and Gynecology, 2022
Recurrent cervical cancer has a grim prognosis with 5-year survival
Maya Gross, Ryan J. Spencer
doaj   +1 more source

Anti-tumour and radiosensitising effects of PARP inhibitor on cervical cancer xenografts

Journal of Obstetrics and Gynaecology, 2023
This study evaluated the radiosensitising effect of niraparib; a poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor on HeLa cervical cancer cells in nude mice and explored its possible mechanism.
Qin Xue, Wang Enyang, Gong Tingting, Ma Xiaolin, Ma Qipeng, Gao Song   +5 more
doaj   +1 more source

Two cases of CRPC with BRCA mutation treated by olaparib after favorable response to cisplatin

IJU Case Reports, 2023
Introduction Several prostate cancers carry homologous recombination repair mutations that respond to olaparib. Because of the mechanism, the efficacy of platinum‐based therapy can be used to predict the efficacy of poly(adenosine diphosphate‐ribose ...
Yoshiyuki Miyazawa, Takanori Shimizu, Yoshitaka Sekine, Seiji Arai, Akira Ohtsu, Yuji Fujizuka, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Kazuhiro Suzuki   +9 more
doaj   +1 more source

Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application [PDF]

Exploration of Drug Science
Pentafuranosylnucleos(t)ides represent a class of natural compounds regulating diverse cell functions being preferably components of biopolymers and also participating as cyclic regulatory low-molecular ligands.
Dmitrii Platov, Anna Kozlova, Cyril Alexeev, Mikhail Drenichev   +3 more
doaj   +1 more source

Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation. [PDF]

PLoS Biology, 2016
The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage.
Xin Sun, Kai Fu, Andrea Hodgson, Eric M Wier, Matthew G Wen, Olena Kamenyeva, Xue Xia, Lily Y Koo, Fengyi Wan   +8 more
doaj   +1 more source

Complete response to orally administered melphalan in malignant pleural effusion from an occult female genital organ primary neoplasm with BRCA1/2 mutations: a case report

Journal of Medical Case Reports, 2018
Background Definite diagnosis of metastasis from unknown primary depends on a comprehensive immunohistochemical investigation of tumor specimen. Accurate identification of the origin site usually helps a lot in choosing the most appropriate treatment ...
Frank S. Fan, Chung-Fan Yang
doaj   +1 more source