Results 61 to 70 of about 657,615 (203)

Delineation of molecular characteristics in pediatric PFA ependymoma involving rare osseous and pulmonary metastases: A case report and literature review

Frontiers in Oncology, 2022
Ependymoma is the third most common pediatric primary brain tumor, with its most aggressive subtype being posterior fossa group A (PFA). Extraneural metastasis of pediatric PFA ependymoma is rare.
Mading Zhou, Leiming Wang, Peng Sun, Yutong Liu, Ge Chen, Gao Zeng   +5 more
doaj   +1 more source

Synthesis of ribosyl-ribosyl-adenosine-5 ',5 '',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose) [PDF]

, 2017
Poly-adenosine diphosphate ribose (PAR) is a branched biopolymer that occurs as a result of post-translational modification of proteins. In 1981 Miwa et al. determined the structure of enzymatically prepared branched PAR.
Filippov, D.V., Overkleeft, H.S., Liu, Q., Kistemaker, H.A.V., Qiang Liu, Hans. A. V. Kistemaker, Herman S. Overkleeft, Dmitri V. Filippov, Marel, G.A. van der, Gijsbert A. van der Marel   +9 more
core   +1 more source

Splitting of the Ribose-Ribose Linkage of Poly(Adenosine Diphosphate-Ribose) by a Calf Thymus Extract

Journal of Biological Chemistry, 1971
Abstract Poly(ADP-Rib) was hydrolyzed by a calf thymus nuclear preparation. The reaction products were ADP-Rib and oligo(ADP-Rib). This reaction is a novel mechanism for degradation of poly(ADP-Rib).
M, Miwa, T, Sugimura
openaire   +2 more sources

Metabolomics of Eryngium heterophyllum by UHPLC‐QToF‐MS and In Silico Insights Into Potential Metabolic Syndrome Targets

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Eryngium heterophyllum has 85 metabolites according to nontargeted UHPLC‐QTOF‐MS profiling, with flavonoids and phenylpropionic acids emerging as significantly related bioactive families. In silico compound–disease–target networks connect 31 metabolites to inflammation, diabetes, obesity, and cardiovascular disease associated with metabolic syndrome ...
Citlaly Gutiérrez‐Rodelo, Laura Elisa Moreno Galván, Eric Estrada‐Lugo, Bharathi Avula, Ikhlas A. Khan, Andrés Navarrete   +5 more
wiley   +1 more source

Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38 [PDF]

, 2014
Cyclic adenosine 5′-diphosphate ribose (cADPR) analogs based on the cyclic inosine 5′-diphosphate ribose (cIDPR) template were synthesized by recently developed stereo- and regioselective N1-ribosylation.
Graeff, Richard, Graeff, RM, Hao, Q, Thomas, MP, Swarbrick, Joanna M., Mark P. Thomas (423555), Potter, BVL, Quan Hao (67204), Thomas, Mark P., Zhang, Hongmin, Potter, Barry V L, Hao, Quan, Swarbrick, JM, Hongmin Zhang (1340733), Joanna M. Swarbrick (1285617), Barry V. L. Potter (286876), Zhang, H, Richard Graeff (423553)   +17 more
core   +1 more source

Controversies and clinical unknowns in the use of PARP inhibitors in ovarian cancer

Therapeutic Advances in Medical Oncology
Poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPi) have significantly improved the treatment of advanced ovarian cancer, however, there are still many aspects of their use that require further understanding.
Uma A. Mukherjee, Rowan E. Miller, Jonathan A. Ledermann   +2 more
doaj   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

First-line treatment of advanced ovarian cancer: an expert update

Libri Oncologici, 2020
Ovarian cancer is the fifth most common cause of death among malignant diseases in women in Europe. The standard treatment is cytoreductive surgery, followed by platinum-taxane based chemotherapy.
Branka Petrić-Miše
doaj   +1 more source

Bovine thymus poly(adenosine diphosphate ribose) polymerase.

Journal of Biological Chemistry, 1978
About 1,300-fold purification of poly(adenosine diphosphate ribose) polymerase has been achieved from the extract of bovine thymus with a recovery of 10 to 20%. The final preparation has a purity of 99%, and the enzyme is composed of a single peptide with a molecular weight of 130,000. The purified enzyme required NAD+, Mg2+, a thiol compound, DNA, and
K, Yoshihara, T, Hashida, Y, Tanaka, H, Ohgushi, H, Yoshihara, T, Kamiya   +5 more
openaire   +2 more sources

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source