Results 61 to 70 of about 7,599 (172)

Ferrichrome identified from induces apoptosis through its iron-binding site in gastric cancer cells

Tumor Biology, 2017
Ferrichrome is known to be a siderophore, but it was recently identified as a tumor-suppressive molecule derived from Lactobacillus casei ATCC334 ( L. casei ). In the present study, we investigated the effects of ferrichrome in gastric cancer cells. Cell
Masami Ijiri, Mikihiro Fujiya, Hiroaki Konishi, Hiroki Tanaka, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Junpei Sasajima, Katsuya Ikuta, Toshikatsu Okumura   +9 more
doaj   +1 more source

Dietary Ergothioneine as a Novel Anti‐Aging Nutraceutical: Mechanisms, Bioavailability, and Future Perspectives

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Ergothioneine (EGT), a natural thiol derivative, has gained attention as a geroprotective nutraceutical. Preclinical research shows EGT scavenges free radicals, maintains mitochondrial integrity, slows telomere erosion, and regulates proteostasis via autophagy and senescent cell clearance.
Tian‐Tian Tian, Liang Chen, Zhen‐Zhen Dong, Chao Yang   +3 more
wiley   +1 more source

Intracellular NAD+ Depletion Increases Prostanoid Production via p38/COX2 Signalling in FK866‐Induced Senescent Human Umbilical Vein Endothelial Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Vascular endothelial cells maintain vascular homeostasis by releasing mediators with vasoconstrictive and vasorelaxant effects. Prostanoids are bioactive substances synthesised by cyclooxygenase2 (COX2); they preserve vascular function and can increase the risk of cardiovascular disease (CVD) associated with ageing.
Natsuko Kitajima, Takahisa Nakajo, Takeshi Katayoshi, Kentaro Tsuji   +3 more
wiley   +1 more source

A phase 1 study of ASTX727 plus talazoparib in patients with triple‐negative or hormone resistant/HER2‐negative metastatic breast cancer

Cancer, Volume 132, Issue 8, 15 April 2026.
Abstract Background Poly(adenosine diphosphate ribose) polymerase (PARP) is recruited to DNA damage sites along with epigenetic factors such as DNA methyltransferase 1 (DNMT1). Inhibitors of DNMT modulate reactive oxygen species (ROS)‐cyclic adenosine monophosphate (cAMP)/Protein Kinase A signaling and induce a “BRCAness phenotype” that further ...
Kathy D. Miller, Alexandra Thomas, Sandra Althouse, Yong Zang, Erin Conder, Ryan Burgos, Bryan P. Schneider, Tarah Ballinger, Emily Douglas, Katherine Ansley, H. Josh Jang, Woonbok Chung, Jean‐Pierre Issa, Kenneth P. Nephew, Feyruz V. Rassool   +14 more
wiley   +1 more source

Progress in targeted therapy for breast cancer

Chronic Diseases and Translational Medicine, 2018
Breast cancer is a multistep, multifactorial, and heterogeneous disease. Significant transformations have occurred in the systemic management of breast cancer in the past decade.
Jie Ju, An-Jie Zhu, Peng Yuan
doaj   +1 more source

PARP Inhibitors in Biliary Tract Cancer: A New Kid on the Block?

Medicines, 2020
Poly adenosine diphosphate-ribose polymerase inhibitors (PARPi) represent an effective therapeutic strategy for cancer patients harboring germline and somatic aberrations in DNA damage repair (DDR) genes.
Angela Dalia Ricci, Alessandro Rizzo, Chiara Bonucci, Nastassja Tober, Andrea Palloni, Veronica Mollica, Ilaria Maggio, Marzia Deserti, Simona Tavolari, Giovanni Brandi   +9 more
doaj   +1 more source

Purification and properties of poly(adenosine diphosphate ribose) synthetase.

Journal of Biological Chemistry, 1977
Poly(ADP-ribose) synthetase has been purified approximately 5000-fold from rat liver nuclei. The activity of the purified enzyme is absolutely dependent upon the presence of native or synthetic DNA, and the further addition of histone(s) stimulates the activity 3- to 5-fold.
H, Okayama, C M, Edson, M, Fukushima, K, Ueda, O, Hayaishi   +4 more
openaire   +2 more sources

Multi‐Omics Profiling Uncovers Predictive Factors for Tumor‐Infiltrating Lymphocyte Therapy in Ovarian Cancer

Journal of Clinical Laboratory Analysis, Volume 40, Issue 8, April 2026.
We profiled tumors from 10 ovarian cancer patients with whole‐exome sequencing (WES), bulk RNA‐seq, and single‐cell RNA‐seq to uncover predictors of successful tumor‐infiltrating lymphocyte (TIL) isolation and expansion. TIL+ tumors exhibited enriched CD8+ Teff/Tem populations with distinctive metabolic activity, dendritic‐cell–skewed myeloid states ...
Xiuzhen Wang, Rui Hou, Jinguo Chen, Bo He, Peiwen Liu, Genhai Zhu, Lan Hong, Wenjun Zhu   +7 more
wiley   +1 more source

Effects of DTX3L on the cell proliferation, adhesion, and drug resistance of multiple myeloma cells

Tumor Biology, 2017
Cell adhesion–mediated drug resistance is an important factor that influences the effects of chemotherapy in multiple myeloma. DTX3L, a ubiquitin ligase, plays a key role in cell-cycle-related process.
Yaodong Shen, Yuxiang Sun, Linlin Zhang, Hong Liu   +3 more
doaj   +1 more source

Enzymic Adenosine Diphosphate Ribosylation of Histone and Poly Adenosine Diphosphate Ribose Synthesis in Rat Liver Nuclei

Journal of Biological Chemistry, 1968
An enzyme associated with mammalian chromatin catalyzed the transfer of the adenosine diphosphate ribose moiety of nicotinamide adenine dinucleotide to histone with the simultaneous release of nicotinamide. A successive transfer of the ADP-ribose moiety resulted in the formation and elongation of a homopolymer with repeating ADP-ribose units ...
Y, Nishizuka, K, Ueda, T, Honjo, O, Hayaishi   +3 more
openaire   +2 more sources