Role of insulin-like growth factor binding protein-3 in 1, 25-dihydroxyvitamin-d 3 -induced breast cancer cell apoptosis. [PDF]
, 2013 Insulin-like growth factor I (IGF-I) is implicated in breast cancer development and 1, 25-dihydroxyvitamin D3 (1, 25-D3) has been shown to attenuate prosurvival effects of IGF-I on breast cancer cells.
Brosseau, C, Colston, KW, Pirianov, G
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Purification and properties of poly(adenosine diphosphate ribose) synthetase.
Journal of Biological Chemistry, 1977 Poly(ADP-ribose) synthetase has been purified approximately 5000-fold from rat liver nuclei. The activity of the purified enzyme is absolutely dependent upon the presence of native or synthetic DNA, and the further addition of histone(s) stimulates the activity 3- to 5-fold.
H, Okayama +4 more
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Effect of 3-aminobenzamide on chromosome damage in human blood lymphocytes adapted to bleomycin [PDF]
, 2017 Human blood lymphocytes, pre-treated with very low (adaptation) concentrations of bleomycin for 48 h and then exposed to a high (challenge) dose of the same agent or X-rays, became significantly less sensitive to the induction of chromosome damage than ...
Burkart, W., Vijayalaxmi,,
core
Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment [PDF]
, 2016 Background: Despite standard treatment for epithelial ovarian cancer (EOC), that involves cytoreductive surgery followed by platinum-based chemotherapy, and initial high response rates to these, up to 80 % of patients experience relapses with a median ...
Caruso, Davide +4 more
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Poly Adenosine Diphosphate-Ribose Polymerase Inhibitors and Heat Shock Protein 90 Inhibitors [PDF]
, 2011 Gregory J. Riely
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Unlocking Therapeutic Potential of Poly(Adenosine Diphosphate Ribose) Polymerase (PARP) Inhibitors in Metastatic Breast Cancer With BRCA Gene Mutations: A Narrative Review. [PDF]
Cureus, 2023 Jain P.
europepmc +1 more source
Prospects for non-immunological molecular therapeutics in melanoma [PDF]
, 2010 In 2006 there were 60,000 new cases of cutaneous melanoma in the European Union and 13,000 deaths (www.europeancancerleagues.org). Currently available systemic treatment options for metastatic melanoma, including both cytotoxic and immunologic therapies,
Crown, John +4 more
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Reduced nicotinamide adenine dinucleotide fluorescence lifetime detected poly(adenosine-5ʹ-diphosphate-ribose) polymerase-1-mediated cell death and therapeutic effect of pyruvate [PDF]
, 2011 Han-Wen Guo +2 more
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Neural Regeneration ResearchFor diverse neurodegenerative disorders, microglial cells are activated. Furthermore, dysfunctional and hyperactivated microglia initiate mitochondrial autophagy, oxidative stress, and pathological protein accumulation, ending with neuroinflammation that
Wenhui Zhao +4 more
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Accumulation of poly (adenosine diphosphate-ribose) by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells. [PDF]
World J Gastroenterol, 2022 Jeong KY, Sim JJ, Park M, Kim HM.
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