Results 131 to 140 of about 7,599 (172)
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Poly(adenosine diphosphate ribose)
1982Publisher Summary This chapter discusses the higher-order structure of poly(adenosine diphosphate ribose) [poly(ADPR)], poly(ADPR) polymerase purification and its properties, and molecular mechanisms of histone- and elongation-factor (EF-2)-ADP-ribosylation.
P, Mandel, H, Okazaki, C, Niedergang
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Studies on anti-poly(adenosine diphosphate ribose) antibody
Biochemical and Biophysical Research Communications, 1974Summary Specific antibody against poly(ADP-Rib) was produced in a rabbit by injecting poly(ADP-Rib) mixed with methylated bovine serum albumin. Under standardized conditions, 1 mg of purified anti-poly(ADP-Rib) antibody combined with 400 pmoles (4 μg) of poly(ADP-Rib) and was retained on a millipore filter.
Y, Kanai +3 more
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Noncovalent interactions of poly(adenosine diphosphate ribose) with histones
Biochemistry, 1992Covalent linkage of ADP-ribose polymers to proteins is generally considered essential for the posttranslational modification of protein function by poly(ADP-ribosyl)ation. Here we demonstrate an alternative way by which ADP-ribose polymers may modify protein function.
Panzeter PL, Realini CA, Althaus FR
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Poly(adenosine diphosphate ribose) glycohydrolase in Physarum polycephalum
Archives of Biochemistry and Biophysics, 1976Abstract Poly(adenosine diphosphate ribose) glycohydrolase, which has thus far only been found in mammalian tissues, was found for the first time in the primitive eukaryotic slime mold Physarum polycephalum. The hydrolytic product of poly(adenosine diphosphate ribose) with this enzyme was identified as adenosine diphosphate ribose by paper and thin ...
M, Tanaka +4 more
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The Involvement of Poly(Adenosine Diphosphate-Ribose) in Deoxyribonucleic Acid Repair
Biochemical Society Transactions, 1978Poly(ADP-ribose) is a nuclear protein modification whose synthesis from NAD is catalysed by the chromatin-bound DNA-dependent enzyme poly(ADP-ri bose) polymerase (Hilz S Hayaishi & Ueda, 1977). The majority of the extensive NAD turnover that takes place in mammalian cells is localized in the nucleus and is thought to involve this enzyme (Rechsteiner et
M I, Davies +4 more
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Poly(adenosine diphosphate ribose)
1973Publisher Summary This chapter discusses that incorporation of radioactivity of (adenine- 14 C) ATP into the acid insoluble material in a nuclear preparation from hen liver is enhanced at least 1000-fold by the presence of NMN. It is confirmed that this stimulation: using a nuclear preparation from rat liver.
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Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).
Biochemistry, 1986Poly(adenosine 5'-diphosphate ribose) [poly(ADP-ribose]) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide, especially in 0.5 M NaCl and at an alkaline pH. The ADP-ribose residues are monomeric and are attached to the middle of polymer chains.
M, Ikejima, D M, Gill
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Purification and characterization of human lymphoid poly(adenosine diphosphate ribose) polymerase
Biochemistry, 1982Poly(ADP-ribose) polymerase has been purified 12 000-fold from human tonsils with an 83% recovery of enzymatic activity relative to that of the initial homogenate. The specific activity of the purified enzyme is 862 units/mg of protein. The isolated protein has a molecular weight of approximately 116 000 as determined by sodium dodecyl sulfate ...
S G, Carter, N A, Berger
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IMMUNOHISTOCHEMICAL DEMONSTRATION OF POLY(ADENOSINE DIPHOSPHATE‐RIBOSE) SYNTHESIS IN HUMAN SKIN
The Journal of Dermatology, 1982ABSTRACTThe distribution of poly(adenosine diphosphate‐ribose) [poly(ADP‐ribose)] synthesis in human skin was investigated by an indirect immunofluorescence technique using a specific antibody against poly(ADP‐ribose). In normal skin, the specific immunofluorescence of poly(ADP‐ribose) was observed in nuclei of not only epidermal cells but also cells ...
K, Ikai, K, Danno, S, Imamura, K, Ueda
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Inhibition of poly(adenosine diphosphate-ribose) polymerase using quinazolinone nucleus
Applied Microbiology and Biotechnology, 2016Poly(adenosine diphosphate-ribose) polymerase (PARP) is a group of enzymes with several subtypes and it manages various ailment such as cancer, inflammatory disorders, diabetes mellitus, neuronal injury, HIV infection, Parkinsonism, aging, and ischemia-reperfusion injury.
K, Hemalatha, G, Madhumitha
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