Results 111 to 120 of about 657,615 (203)

Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted ¹⁸F-Fluorthanatrace PET Images of Ovarian Cancer. [PDF]

J Nucl Med, 2022
Young AJ, Pantel AR, Viswanath V, Dominguez TL, Makvandi M, Lee H, Li S, Schubert EK, Pryma DA, Farwell MD, Mach RH, Simpkins F, Lin LL, Mankoff DA, Doot RK.   +14 more
europepmc   +1 more source

Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D

, 2007
Vitamin D is well characterized for its role in mineral homeostasis and maintenance of normal skeletal architecture. Vitamin D has been demonstrated to exert anti-inflammatory effects in a variety of disease states including diabetes, arthritis and ...
Szabo, C., Mabley, Jon; id_orcid, Wallace, R., Pacher, P., Murphy, K.   +4 more
core  

Patient cost sharing during poly(adenosine diphosphate-ribose) polymerase inhibitor treatment in ovarian cancer. [PDF]

Am J Obstet Gynecol, 2021
Harrison RF, Fu S, Sun CC, Zhao H, Lu KH, Giordano SH, Meyer LA.   +6 more
europepmc   +1 more source

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1

, 2009
Posttranslational modifications play key roles in regulating chromatin plasticity. Although various chromatin-remodeling enzymes have been described that respond to specific histone modifications, little is known about the role of poly[adenosine 5 ...
Polo, Sophie E., West, SC, Garcia-Wilson, E., Polo, SE, Horejsi, Zuzana, Horejsi, Z., Boulton, Simon J., Skehel, Mark, Ahel, I, Skehel, M, Ahel, D, Boulton, S., Flynn, H, Owen-Hughes, Tom; id_orcid, Garcia-Wilson, E, Jackson, Stephen P., Ahel, Dragana, Wiechens, N, Ahel, D., Skehel, M., Jackson, S., Boulton, SJ, Owen-Hughes, T, Wiechens, N., Horejsí, Z, West, S., Flynn, Helen, Ahel, I., Flynn, H., West, Stephen C., Wiechens, Nicola, Garcia-Wilson, Elisa, Ahel, Ivan, Jackson, SP, Polo, S., Owen-Hughes, T.   +35 more
core   +1 more source

Studies on Poly (Adenosine Diphosphate Ribose)

Journal of Biological Chemistry, 1970
Hirotaka Matsubara, Shuji Hasegawa, Shinji Fujimura, Teruo Shima, Takashi Sugimura, Masamitsu Futai   +5 more
openaire   +1 more source

Poly(adenosine diphosphate ribose) Synthesis in Soluble Extracts of Animal Organs

Journal of Biological Chemistry, 1972
Abstract Poly(adenosine diphosphate ribose) (poly(ADP-ribose)) which is normally synthesized in chromatin is also synthesized from NAD by soluble extracts of animal organs prepared in 0.5 m NaCl, KCl, or NH4Cl. Extracts of thymus, bone marrow, lymph nodes, and spleen are the most active.
openaire   +2 more sources

Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.

, 2011
Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH ...
Moreau, C, Christelle Moreau, Bailey, VC, Victoria C. Bailey, Gloria A. Ashamu, Andreas H. Guse, Guse, AH, Antony Galione, Barry V. L. Potter, Potter, BV, Ashamu, GA, Galione, A, Galione, Antony   +12 more
core   +1 more source

Synthesis of 7-deaza-8-bromo cyclic adenosine 5′-diphosphate ribose: The first hydrolysis resistant antagonist at the cADPR receptor

, 1997
7-Deaza-8-bromo cyclic adenosine 5′-diphosphate ribose is synthesised from 7-deazaadenosine via 7-deaza-8-bromo nicotinamide adenine dinucleotide; it is both a more potent antagonist than the 8-bromo derivative and has the advantage of chemical and ...
Bailey, Victoria C., Potter, Barry V.L., Sethi, Jaswinder K., Galione, Antony   +3 more
core   +1 more source

PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease

MedComm
The poly(ADP‐ribose) polymerase (PARP) family consists of 17 members of nicotinamide adenine dinucleotide (NAD⁺)‐dependent enzymes that regulate key biological processes by catalyzing adenosine diphosphate (ADP)‐ribosylation, either poly(ADP‐ribosyl ...
Pengyuan Lei, Wenfeng Li, Jinhua Luo, Nanxin Xu, Yahe Wang, Dafei Xie, Hua Guan, Bo Huang, Xin Huang, Pingkun Zhou   +9 more
doaj   +1 more source

Progesterone Enhances Niraparib Efficacy in Ovarian Cancer by Promoting Palmitoleic-Acid-Mediated Ferroptosis

Research
Poly (adenosine 5′-diphosphate-ribose) polymerase inhibitors (PARPi) are increasingly important in the treatment of ovarian cancer. However, more than 40% of BRCA1/2-deficient patients do not respond to PARPi, and BRCA wild-type cases do not show obvious
Nayiyuan Wu, Xiu Zhang, Chao Fang, Miaochen Zhu, Zhibin Wang, Lian Jian, Weili Tan, Ying Wang, He Li, Xuemeng Xu, Yujuan Zhou, Tang-Yuan Chu, Jing Wang, Qianjin Liao   +13 more
doaj   +1 more source