Results 131 to 140 of about 18,599 (272)

Poly Adenosine Diphosphate-Ribose Polymerase Inhibitors and Heat Shock Protein 90 Inhibitors [PDF]

, 2011
Gregory J. Riely
openalex   +1 more source

Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications [PDF]

, 2012
Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation ...
Jin, H, Yang, Z, Yu, P, Yue, J, Zhang, L, Zhang, L, Zhou, Y   +6 more
core   +2 more sources

Purification and properties of poly(adenosine diphosphate ribose) synthetase.

Journal of Biological Chemistry, 1977
Poly(ADP-ribose) synthetase has been purified approximately 5000-fold from rat liver nuclei. The activity of the purified enzyme is absolutely dependent upon the presence of native or synthetic DNA, and the further addition of histone(s) stimulates the activity 3- to 5-fold.
H, Okayama, C M, Edson, M, Fukushima, K, Ueda, O, Hayaishi   +4 more
openaire   +2 more sources

Reduced nicotinamide adenine dinucleotide fluorescence lifetime detected poly(adenosine-5ʹ-diphosphate-ribose) polymerase-1-mediated cell death and therapeutic effect of pyruvate [PDF]

, 2011
Han-Wen Guo, Yau‐Huei Wei, Hsing-Wen Wang   +2 more
openalex   +1 more source

BRCA1 CpG Island Hypermethylation Predicts Sensitivity to Poly(Adenosine Diphosphate)- Ribose Polymerase Inhibitors [PDF]

, 2010
Jürgen Veeck, Santiago Ropero, Fernando Setién, Eva González‐Suárez, Ana Osório, Javier Benı́tez, James G. Herman, Manel Esteller   +7 more
openalex   +1 more source

Homologous recombination deficiency (HRD) signature-3 in ovarian and uterine carcinosarcomas correlates with preclinical sensitivity to Olaparib, a poly (adenosine diphosphate [ADP]- ribose) polymerase (PARP) inhibitor.

Gynecologic Oncology, 2022
J. Tymon-Rosario, P. Manara, Diego D Manavella, S. Bellone, Tobias M. Hartwich, J. Harold, Yang Yang-Hartwich, Margherita Zipponi, Jungmin Choi, Kyungjo Jeong, L. Mutlu, Kevin Yang, G. Altwerger, G. Menderes, E. Ratner, Gloria S. Huang, M. Clark, V. Andikyan, M. Azodi, P. Schwartz, L. Alexandrov, A. Santin   +21 more
semanticscholar   +1 more source

Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications

Neural Regeneration Research
For diverse neurodegenerative disorders, microglial cells are activated. Furthermore, dysfunctional and hyperactivated microglia initiate mitochondrial autophagy, oxidative stress, and pathological protein accumulation, ending with neuroinflammation that
Wenhui Zhao, Zhongxuan Liu, Jiannan Wu, Anran Liu, Junqiang Yan   +4 more
doaj   +1 more source

Accumulation of poly (adenosine diphosphate-ribose) by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells. [PDF]

World J Gastroenterol, 2022
Jeong KY, Sim JJ, Park M, Kim HM.
europepmc   +1 more source

Properties of Purified Calf Thymus Poly(Adenosine Diphosphate Ribose) Polymerase. Comparison of the DNA-Independent and the DNA-Dependent Enzyme [PDF]

, 1979
Claude Niedergang, Hideo Okazaki, Paul Mandel   +2 more
openalex   +1 more source

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites [PDF]

, 2017
Poly(ADP-ribose) polymerase 1 (PARP1) synthesizes poly(ADP-ribose) (PAR) using nicotinamide adenine dinucleotide (NAD) as a substrate. Despite intensive research on the cellular functions of PARP1, the molecular mechanism of PAR formation has not been ...
Altmeyer, Matthias, Fey, Monika, Hassa, Paul O., Hottiger, Michael O., Messner, Simon   +4 more
core