Results 131 to 140 of about 18,215 (242)

Inhibitors targeting CDK4/6, PARP and PI3K in breast cancer: a review

Therapeutic Advances in Medical Oncology, 2018
Breast cancer is the global leading cause of cancer-related death in women and it represents a major health burden worldwide. One of the promising breast cancer therapeutic avenues is through small molecule inhibitors (SMIs) which have undergone rapid ...
Siti Muhamad Nur Husna, Hern-Tze Tina Tan, Rohimah Mohamud, Anne Dyhl-Polk, Kah Keng Wong   +4 more
doaj   +1 more source

The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 2: extending the scope beyond olaparib and BRCA1/2 mutations [PDF]

, 2016
Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors have shown clinical activity in epithelial ovarian cancer, leading both the US Food and Drug Administration (FDA) and the European Medicines Agency to approve olaparib for tumors ...
Ledermann, JA, Miller, RE
core  

Salvage enzymes in nucleotide biosynthesis [PDF]

, 2007
Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core  

Método para reconstrução in silico de redes metabólicas de fungos : um estudo de caso para o Paracoccidioides lutzii [PDF]

, 2014
Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Exatas, Departamento de Ciência da Computação, 2014.Os fungos produzem uma variedade de metabólitos com aplicações na indústria e na medicina, ao mesmo tempo que podem ser patógenos ...
Silva, Waldeyr Mendes Cordeiro da
core  

Patient cost sharing during poly(adenosine diphosphate-ribose) polymerase inhibitor treatment in ovarian cancer. [PDF]

Am J Obstet Gynecol, 2021
Harrison RF, Fu S, Sun CC, Zhao H, Lu KH, Giordano SH, Meyer LA.   +6 more
europepmc   +1 more source

Studies on Poly (Adenosine Diphosphate Ribose)

Journal of Biological Chemistry, 1970
Hirotaka Matsubara, Shuji Hasegawa, Shinji Fujimura, Teruo Shima, Takashi Sugimura, Masamitsu Futai   +5 more
openaire   +1 more source

Abstracts of the 18th SCWD Conference, 11‐13 December 2025 in Rome/Italy

JCSM Communications, Volume 9, Issue 1, January/June 2026.
wiley   +1 more source

PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease

MedComm
The poly(ADP‐ribose) polymerase (PARP) family consists of 17 members of nicotinamide adenine dinucleotide (NAD⁺)‐dependent enzymes that regulate key biological processes by catalyzing adenosine diphosphate (ADP)‐ribosylation, either poly(ADP‐ribosyl ...
Pengyuan Lei, Wenfeng Li, Jinhua Luo, Nanxin Xu, Yahe Wang, Dafei Xie, Hua Guan, Bo Huang, Xin Huang, Pingkun Zhou   +9 more
doaj   +1 more source

Adenosine diphosphate-ribosylation greatly affects proteins function: a focus on neurodegenerative diseases

Frontiers in Aging Neuroscience
Adenosine diphosphate-ribosylation (ADPRylation) is a reversible posttranslational modification that plays a crucial role in cellular homeostasis and disease development.
Chaowen Huang, Huilin Xiao, Yang Yang, Jiankun Luo, Yixi Lai, Shizhen Liu, Kanmin Mao, Jialong Chen, Liling Wang   +8 more
doaj   +1 more source

Progesterone Enhances Niraparib Efficacy in Ovarian Cancer by Promoting Palmitoleic-Acid-Mediated Ferroptosis

Research
Poly (adenosine 5′-diphosphate-ribose) polymerase inhibitors (PARPi) are increasingly important in the treatment of ovarian cancer. However, more than 40% of BRCA1/2-deficient patients do not respond to PARPi, and BRCA wild-type cases do not show obvious
Nayiyuan Wu, Xiu Zhang, Chao Fang, Miaochen Zhu, Zhibin Wang, Lian Jian, Weili Tan, Ying Wang, He Li, Xuemeng Xu, Yujuan Zhou, Tang-Yuan Chu, Jing Wang, Qianjin Liao   +13 more
doaj   +1 more source