Results 111 to 120 of about 81,988 (275)
UroPrecision, EarlyView.Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley +1 more source
Staging concept for aging management: Definition, mechanism, and coping strategies
VIEW, EarlyView.We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang +6 more
wiley +1 more source
, 2016 Phosphorylation is a very common post-translational modification event known to modulate a wide range of biological responses. Beyond the regulation of protein activity, the interrelation of phosphorylation with other post-translational mechanisms is ...
Arnaud Droit (36418) +10 more
core +2 more sources
PARP1 and PARG Are the Draft Horses for Polycomb-Trithorax Chromatin Regulator Machinery
BiomoleculesDuring tissue differentiation, gene expression patterns are committed to the epigenetic cellular memory machinery, including Polycomb and Trithorax groups (PcG and TrxG), which label chromatin with repressive or active histone marks.
Guillaume Bordet, Alexei V. Tulin
doaj +1 more source
Mutagenesis in cultured cells with altered poly (Adp-ribose) metabolism
, 1986 Poly(ADP-ribose) is synthesized in response to DNA damage caused by either chemicals or radiation. The biological function of this polymer is not known.
Nunbhakdi, Viyada
core
Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances
Andrology, EarlyView.ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang +4 more
wiley +1 more source
Ablative radiotherapy in castration‐resistant prostate cancer
BJU International, EarlyView.Objective To prove the oncological benefit of ablative radiotherapy in patients with up to five metastases from castration‐resistant prostate cancer (CRPC) a single‐centre randomised trial was initiated. Patients and Methods This monocentric, randomised, phase II clinical trial enrolled patients with up to five prostate‐specific membrane antigen ...
Tobias Hölscher +9 more
wiley +1 more source
Étude fonctionnelle de la poly(ADP-ribose) glycohydrolase (PARG)
, 2004 La poly(ADP-ribosylation) est une modification post-traductionnelle des protéines régulée essentiellement par la poly(ADP-ribose) polymérase I (PARP-1), synthétisant le poly(ADP-ribose), et la poly(ADP-ribose) glycohydrolase (PARG), responsable du ...
WANG, Zhao Qiu, CORTES, Ulrich
core
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source