Results 121 to 130 of about 81,988 (275)
Prospects for non-immunological molecular therapeutics in melanoma [PDF]
, 2010 In 2006 there were 60,000 new cases of cutaneous melanoma in the European Union and 13,000 deaths (www.europeancancerleagues.org). Currently available systemic treatment options for metastatic melanoma, including both cytotoxic and immunologic therapies,
Tryfonopoulos, Dimitrios +5 more
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Increased Poly(ADP-ribose) activity in the brain with age.
, 2013 (A) PARP activity was determined in aging tissue using a spectrophotometric assay. All values are means ± S.E from tissue obtained from eight different rats for each age group. Significance
Ross Grant (313891) +5 more
core +1 more source
Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development
Cancer Science, EarlyView.Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura +3 more
wiley +1 more source
OPTIMIZATION OF 2'-О-α-D-RIBOFURANOSYLADENOSINE SYNTHESIS USING THE SIMPLEX PLANNING METHOD
Тонкие химические технологии, 2013 Disaccharide nucleosides belong to an important group of natural compounds found in t-RNA and poly(ADPribose). They are also key elements in the structure of antibiotics and other physiologically active compounds.
V. E. Oslovsky +3 more
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Synthesis, Purification and Pharacterization of Small Mono(ADP-Ribosyl)ated Molecules in the ADP-Ribose Elongation Reaction Catalyzed by Poly(ADP-ribose)Polymerase [PDF]
, 1993 The ADP-ribose elongation catalyzed by poly(ADP-ribose) polymerase (PARP) [EC 2.2.2.30] has been partially characterized utilizing mono (ADP-ribosyl)ated polyamines.
Pacheco-Rodriguez, Gustavo
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, 2008 International audiencePoly(ADP-ribose) (pADPr) is a polymer assembled from the enzymatic polymerization of the ADP-ribosyl moiety of NAD by poly(ADP-ribose) polymerases (PARPs).
Hendzel, Michael, J. +7 more
core +1 more source
Cancer Science, EarlyView.Multi‐region sequencing of 57 BRCA1‐associated breast cancers identified TP53 as the dominant initial driver, defining a triple‐negative subgroup with biallelic BRCA1 loss and elevated genomic instability. TP53 truncating mutations were enriched in BRCA1 carriers and linked to reduced HRD, EMT activation, and a trend toward worse survival.
Li Hu +13 more
wiley +1 more source
The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics
Clinical Genetics, EarlyView.The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree +18 more
wiley +1 more source
Metabolism of Poly-ADP-ribose in Trypanosomatids
, 2010 The poly-ADP-ribosylation reaction is a post-translational modification involved invarious cellular processes including DNA repair, DNA replication, gene expression,maintenance of genomic stability, cell death and cellular differentiation. Poly(ADPribose)
Vilchez Larrea, Salomé Catalina +2 more
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