Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 9, September 2026.Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li +3 more
wiley +1 more source
Poly (ADP-Ribose) Glycohydrolase-Dependent dePARylation of PCNA Is Essential for DNA Replication. [PDF]
FASEB JYan Z +11 more
europepmc +1 more source
Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances
MedComm, Volume 7, Issue 9, September 2026.The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong +5 more
wiley +1 more source
Vascular Protection of Poly(ADP-ribose) Polymerase Inhibitors in the Combination Therapy With Vascular Endothelial Growth Factor Signaling Pathway Inhibitors. [PDF]
Rev Cardiovasc MedMa J +8 more
europepmc +1 more source
Prostate Cancer Development, Progression, and Therapy
MedComm – Oncology, Volume 5, Issue 3, September 2026.This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin +9 more
wiley +1 more source
Dual‐view scout scans with deep learning for ultra‐low dose attenuation correction in PET
Medical Physics, Volume 53, Issue 9, September 2026.Abstract Background Accurate attenuation correction (AC) is essential for quantitative positron emission tomography (PET). Conventional CT‐based AC provides reliable attenuation (μ‐) maps but adds radiation, introduces PET/CT misalignment artifacts, and is unavailable on stand‐alone PET systems.
Florence M. Muller +7 more
wiley +1 more source
Protocol for synthesizing and purifying short-length poly(ADP)ribose polymer using fast protein liquid chromatography. [PDF]
STAR ProtocNeeharika S, Hanuman DS, Rajakumara E.
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The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics
Clinical Genetics, Volume 110, Issue 3, Page 389-401, September 2026.The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree +18 more
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Synergistic Cellular Toxicity from Inhibition of Poly(ADP-ribose) Glycohydrolase (PARG) and Ubiquitin-Specific Protease 1 (USP1). [PDF]
ToxicsLeonard SM +3 more
europepmc +1 more source
The FASEB Journal, Volume 40, Issue 16, 31 August 2026.The zinc transporter ZIP1 is induced promptly following treatment with the DNA damage agent bleomycin through the TNFα–NF‐κB pathway. NF‐κB accumulates in the nucleus and upregulates the transcription of SLC39A1, the coding gene for ZIP1. The increased expression of ZIP1 leads to elevated intracellular zinc levels, which, in turn, enhance the DNA ...
Zichong Li +4 more
wiley +1 more source