Results 151 to 160 of about 667,209 (277)

Poly(ADP-Ribose) polymerase1 Has Potential to Facilitate the Nucleosome Disassembly. [PDF]

Int J Mol Sci
Alekseev AA, Kutuzov MM, Belousova EA, Ukraintsev AA, Goncharov ID, Vasileva AA, Khodorkovskii MA, Lavrik OI.   +7 more
europepmc   +1 more source

Newly identified human aminoacyl‐tRNA synthetase complex interacting multifunctional protein 2 (AIMP2) loss‐of‐function mutations cause neurodevelopmental defects linked to cell death in a zebrafish model

The FEBS Journal, EarlyView.
Human AIMP2 mutations lead to severe neurodevelopmental defects and brain atrophy. Using patient‐derived fibroblasts from two individuals, we show decreased AIMP2 protein levels and overall protein synthesis. In a zebrafish loss‐of‐function model, the lack of AIMP2 leads to an increase in cell death and results in smaller brains.
Patrick Mullen, Shenela Lakhani, Joshua Appelbaum, DéJenaé See, Pryce Patterson, Collin M. MacLeod, Alexandra George, Reza Maroofian, Margaret E. Ross, Christopher Francklyn, Alicia M. Ebert   +10 more
wiley   +1 more source

Hematologic complications in patients exposed to poly- ADP ribose polymerase inhibitors. [PDF]

Haematologica
Cannova JM, Battaglia MR, Roloff GW, Cetin S, Tallarico M, Stock W, Patel AA, Odenike O, Larson RA, Thirman MJ, Nawas MT, Wang P, Tjota MY, Segal JP, Venkataraman G, DuVall AS, Drazer MW.   +16 more
europepmc   +1 more source

Dimerization of human PARP15 is required for NAD+ binding and automodification

The FEBS Journal, EarlyView.
This study provides an integrated structural model of human PARP15. Biophysical, enzymatic, and cell‐based analyses identify the dimer as the active oligomeric state capable of binding the substrate NAD+. A co‐crystal structure with a non‐hydrolyzable substrate analog BAD reveals the molecular basis for the dimerization requirement.
Anna Tuovinen, Johan Pääkkönen, Mirko M. Maksimainen, Lea Hirschen, Heli I. Hentilä, Marie Tauscher, Bernhard Lüscher, Carlos Vela‐Rodríguez, Patricia Korn, Lari Lehtiö   +9 more
wiley   +1 more source

Interaction between Poly(ADP-ribose) polymerase-1 and α-synuclein pathology in Parkinson's disease. [PDF]

Front Neurosci
Zhang P, Li Q, Diao X, Zeng S.
europepmc   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Mendelian Randomization Unveils Poly(ADP-ribose) Polymerase 1 as Causal Plasma Protein Target in Melanoma, Integrated Multi-omics. [PDF]

Plast Reconstr Surg Glob Open
Lu F, Luan W, Jiang H, Ma S, Ruan H.
europepmc   +1 more source

The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models

Photochemistry and Photobiology, EarlyView.
This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva, Rebeca Barros Nascimento, Giovanna Lopes Carvalho, Rebeca Boltes Cecatto, Maria Stella Moreira, Maria Fernanda Setúbal Destro Rodrigues   +5 more
wiley   +1 more source

[Corrigendum] Influence of MLH1 on colon cancer sensitivity to poly(ADP‑ribose) polymerase inhibitor combined with irinotecan. [PDF]

Int J Oncol
Tentori L, Leonetti C, Muzi A, Dorio AS, Porru M, Dolci S, Campolo F, Vernole P, Lacal PM, Praz F, Graziani G.   +10 more
europepmc   +1 more source

Olaparib‐associated cutaneous vasculitis in a patient with breast cancer

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Marcial Álvarez‐Salafranca, Teresa Puértolas, Adrián Diago, María Carmen Gómez‐Mateo   +3 more
wiley   +1 more source