Antitumor activity and structure-activity relationship of poly (ADP-ribose) polymerase (PARP)-based dual inhibitors. [PDF]
J Enzyme Inhib Med ChemYang C +5 more
europepmc +1 more source
Synthesis of the Core Tetracycle of the Spirobiflavonoid Daphnodorin C
European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.Core spirotetracycle of daphnodorin C: Oxidative ring contraction of benzofuro[3,2‐b]chromenones affords novel 2,3′‐spirobi[benzofuran]diones, rather than the isomeric spiroketals. The first synthesis of the spirobi[benzofuran]dione core structure of the spirobiflavonoid daphnodorin C is described.
Lukas Heemann +2 more
wiley +1 more source
Poly (ADP-ribose) polymerase in yeasts: characterization and involvement in telomere maintenance. [PDF]
Nucleic Acids ResSepšiová R +12 more
europepmc +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, Volume 20, Issue 8, Page 1905-1912, August 2026.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Elevated TRIM25 Impairs Poly (ADP-ribose) Metabolism via PARG Degradation and Mediates Compression-Induced Intervertebral Disc Degeneration. [PDF]
Adv Sci (Weinh)Cheng Z +9 more
europepmc +1 more source
Biomedical Chromatography, Volume 40, Issue 8, August 2026.ABSTRACT Olaparib belongs to the PARP inhibitors and is widely used as an anticancer drug. Due to frequent side effects, it is usually co‐administered with an antihypertensive, such as propranolol and/or an antidiuretic, such as furosemide. In this study, a highly sensitive HPLC‐FLD method was developed for the simultaneous determination of the three ...
Georgios Kamaris +2 more
wiley +1 more source
Nucleotide excision repair and poly(ADP-ribose) polymerase 1 cooperate in HBV cccDNA synthesis: A potential viral therapeutic target. [PDF]
JHEP RepHung HC +11 more
europepmc +1 more source
Clinical Advances in Breast Cancer: A Comprehensive Overview of Full‐Course Disease Management
Cancer Innovation, Volume 5, Issue 4, August 2026.This review provides a comprehensive overview of clinical advances in breast cancer, highlighting subtype‐specific therapeutic paradigms. It underscores the full‐cycle integration of innovative therapies, as well as the growing role of biomarker‐guided strategies in advancing precision medicine.
Xuenan Peng, Yujing Tan, Fei Ma
wiley +1 more source
Methyltransferase-Like 3 Inhibition-Activated cGAS/STING Axis Enhances Immunotherapy and Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity in Lung Adenocarcinoma. [PDF]
Research (Wash D C)Zhou J +11 more
europepmc +1 more source
Current Advances of Molecular Biomarkers and Liquid Biopsies Techniques in Ovarian Cancer
Cancer Medicine, Volume 15, Issue 8, August 2026.ABSTRACT Ovarian cancer (OC) remains a lethal gynecological malignancy with challenges in early diagnosis, treatment monitoring, and overcoming drug resistance. Liquid biopsy, a noninvasive approach analyzing tumor‐derived components in bodily fluids, has emerged as a promising tool in OC management.
Jingxia Zhang +5 more
wiley +1 more source