Results 161 to 170 of about 68,992 (261)

Poly(ADP-ribose) glycohydrolase enforces p21 degradation via dePARylation to promote gastric cancer progression. [PDF]

J Clin Invest
Hu Y, Bao Q, Huang Y, Wang Y, Zhao X, Nan J, Meng Y, Deng M, Li Y, Zhuang Z, He H, Zu D, Zhong Y, Zhang C, Wang B, Li R, He Y, Wang Q, Liu M, Tainer JA, Shi Y, Cheng X, Jing J, Ye Z.   +23 more
europepmc   +1 more source

Survival Impact of Programmed Cell Death Ligand‐1 Expression in Patients With Epithelial Ovarian Carcinoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Aims To evaluate the proportion of expressed programmed cell death ligands‐1 (PD‐L1) in epithelial ovarian carcinoma patients, and the association with the clinicopathological, surgical outcomes, and oncologic outcomes. To compare PD‐L1 protein expression with messenger ribonucleic acid (mRNA) expression. Methods The patients who had pathology
Achjima Tankul, Suchanan Hanamornroongruang, Naravat Poungvarin, Rachawalan Suriyasaengsri, Sompop Kuljarusnont, Pornprom Ittiamornlert, Wathirada Karnchanabanyong, Irene Ruengkhachorn, Saowalak Hunnangkul   +8 more
wiley   +1 more source

Identifying potential binding sites for complex formation between Tyrosyl-DNA phosphodiesterase 1 and poly [ADP-ribose] polymerase 1.

Phys Chem Chem Phys
Wang S, Üren A, Tiwari PB.
europepmc   +1 more source

Poly(ADP-ribose) polymerase (PARP) inhibitors in cardiovascular, and cerebrovascular diseases: mechanisms, current trends and challenge for clinical translation. [PDF]

PeerJ
Fan J, Song Y.
europepmc   +1 more source

SMAD4 Expression and Its Association With Treatment Resistance and Clinical Outcomes in Oral Squamous Cell Carcinoma Treated With Preoperative Chemoradiotherapy

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Small mothers against decapentaplegic homologue 4 (SMAD4) plays an important role in transforming growth factor (TGF)‐β signaling and is associated with various cancers. However, little is known about SMAD4 expression in oral squamous cell carcinoma (OSCC).
Junki Sakata, Akiyuki Hirosue, Ryoji Yoshida, Yuichiro Matsuoka, Yusei Todoroki, Hidetaka Arita, Hikaru Nakashima, Tatsuro Yamamoto, Nozomu Takahashi, Masatoshi Hirayama, Kenta Kawahara, Ryo Toya, Ryuji Murakami, Takaaki Ito, Yoshikazu Kuwahara, Hideki Nakayama   +15 more
wiley   +1 more source

Characteristics and Clinical Outcomes of BRCA Germline Mutation Carriers with Advanced Breast Cancer Treated with PARP (Poly ADP-Ribose Polymerase) Inhibitors: A Single-Institution Experience. [PDF]

Cancers (Basel)
Akkoc Mustafayev FN, Fountzilas E, Munsell MF, Layman RM, Yam C, Gutierrez AM, Albarracin CT, Ahmed Z, Schlacher K, Tainer JA, Arun BK.   +10 more
europepmc   +1 more source

Genomic, Trop‐2, and Immune Profiles of Carcinomatous and Sarcomatous Components in Ovarian Carcinosarcoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Ovarian carcinosarcoma (OCS) is a rare, aggressive tumor composed of both carcinomatous and sarcomatous components, typically associated with poor prognosis. Due to its rarity, the molecular characteristics, immune microenvironment, and optimal treatment of OCS remain unclear.
Tomomi Sakamaki, Tatsuyuki Chiyoda, Kohei Nakamura, Reika Takamatsu, Ryutaro Kawano, Daisuke Ochiai, Mitsuyo Jisaka, Mio Takahashi, Takuma Yoshimura, Yumiko Kimura, Shinya Oki, Kensuke Sakai, Tomoko Yoshihama, Hiroshi Nishihara, Wataru Yamagami   +14 more
wiley   +1 more source

Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells. [PDF]

Transl Oncol
Zhang C, Wang P, Yu J, Yuan J, Zhang L, Li M.   +5 more
europepmc   +1 more source

CLRN1 Variants in Müller Cells Cause Mitochondrial Dysfunction in USH3A Retinal Organoids

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
We generated retinal organoids from a patient with USH3A and performed single‐cell RNA sequencing. CLRN1 was specifically expressed in Müller cells, where its variants led to mitochondrial dysfunction and photoreceptor degeneration. ABSTRACT Background Usher syndrome 3A (USH3A), caused by mutations in the CLRN1 gene, leads to retinitis pigmentosa and ...
Rui Zhang, Xinbo Ji, Han Yu, Jingwen Xu, Yu Wang, Ping Sun, Yingxin Wang, Yao Tang, Zexin Zhan, Yichang Jiao, Didi Shan, Pengfei Lin, Dong‐dong Wang, Yuying Zhao, Xianyang Liu, Chuanzhu Yan, Jianqiao Li, Mingfeng Li, Fuchen Liu, Shengping Hou   +19 more
wiley   +1 more source

Advancing gambogic acid for translational oncology: Redox–proteostasis collapse, multidrug resistance reversal, nanodelivery and biomarker‐guided development

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Gambogic acid exerts anticancer effects through reactive oxygen species‐mediated apoptosis, suppression of nuclear factor kappa B and phosphatidylinositol‐3‐kinase–protein kinase B signalling, multidrug resistance modulation and tumour microenvironment effects.
Uttam Singh Baghel, Kajal Gurow, Geetanjali Mehara, Priyanka Kriplani, Neelam M. Patel, Abhay Sharma, Deeksha Singh, Atamjit Singh, Suchi Dave, Bhawani Singh, Lashyn N. Kiyekbayeva, William N. Setzer, Javad Sharifi‐Rad, Cheryl Grace Pratiwi Rumahorbo, Daniela Calina   +14 more
wiley   +1 more source