Results 161 to 170 of about 117,156 (227)

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, Volume 183, Issue 8, Page 1640-1652, April 2026.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Antitumor activity and structure-activity relationship of poly (ADP-ribose) polymerase (PARP)-based dual inhibitors. [PDF]

J Enzyme Inhib Med Chem
Yang C, Shang Y, Li X, Li J, Li H, Han J.   +5 more
europepmc   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Poly (ADP-Ribose) Glycohydrolase-Dependent dePARylation of PCNA Is Essential for DNA Replication. [PDF]

FASEB J
Yan Z, Feng Q, Jiang X, Han X, Qiao Z, Wang Y, Yang X, Liu X, Cheng X, Guo S, Li H, Wu C.   +11 more
europepmc   +1 more source

Novel Silver(I) and Gold(I) N‐Heterocyclic Carbene Complexes Induce ROS‐Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2

Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.
In this research work, the cytotoxicity of eight sulfonated silver(I) and gold(I) N‐heterocyclic carbene (NHC) complexes—four newly synthesized—was evaluated against human liver cancer cells. Two compounds showed selectivity for cancer cells, inducing ROS‐dependent autophagic cell death via AKT/mTOR pathway inhibition without triggering apoptosis ...
Rocchina Miglionico, Francesco Viceconte, Maria Francesca Armentano, Annaluisa Mariconda, Ilaria Nigro, Pasquale Longo, Faustino Bisaccia   +6 more
wiley   +1 more source

Poly (ADP-ribose) polymerase in yeasts: characterization and involvement in telomere maintenance. [PDF]

Nucleic Acids Res
Sepšiová R, Procházková K, Červenák F, Majerčík D, Hanáková K, Lattová E, Hajikazemi M, Zdráhal Z, Virágová S, Brzáčová Z, Paeschke K, Nosek J, Tomáška Ľ.   +12 more
europepmc   +1 more source

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, Volume 158, Issue 6, Page 1617-1627, 15 March 2026.
What's new? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

Poly(ADP-ribose) polymerase (PARP) inhibitors in cardiovascular, and cerebrovascular diseases: mechanisms, current trends and challenge for clinical translation. [PDF]

PeerJ
Fan J, Song Y.
europepmc   +1 more source

Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells. [PDF]

Transl Oncol
Zhang C, Wang P, Yu J, Yuan J, Zhang L, Li M.   +5 more
europepmc   +1 more source

Real-world data-based assessment of therapy-related myeloid neoplasms after poly(ADP-ribose) polymerase inhibitor treatment in ovarian cancer. [PDF]

Front Oncol
Uekusa R, Yokoi A, Watanabe E, Inoue M, Mizuno K, Yoshida K, Yoshikawa N, Niimi K, Suzuki S, Kajiyama H.   +9 more
europepmc   +1 more source