Results 191 to 200 of about 667,209 (277)

Effect of first-line poly(ADP-ribose) polymerase inhibitor on second-line platinum-based chemotherapy in epithelial ovarian cancer. [PDF]

J Gynecol Oncol
Toyohara Y, Yunokawa M, Nimura R, Funada E, Ozawa R, Kato K, Nishino S, Kamata M, Kanno M, Fusegi A, Abe A, Netsu S, Omi M, Aoki Y, Tanigawa T, Okamoto S, Nomura H, Kanao H.   +17 more
europepmc   +1 more source

Ablative radiotherapy in castration‐resistant prostate cancer

BJU International, Volume 138, Issue 4, Page 659-665, October 2026.
Objective To prove the oncological benefit of ablative radiotherapy in patients with up to five metastases from castration‐resistant prostate cancer (CRPC) a single‐centre randomised trial was initiated. Patients and Methods This monocentric, randomised, phase II clinical trial enrolled patients with up to five prostate‐specific membrane antigen ...
Tobias Hölscher, Fabian Lohaus, Lydia Koi, Jörg Kotzerke, Sebastian Hoberück, Christian Thomas, Angelika Borkowetz, Steffen Löck, Mechthild Krause, Esther G.C. Troost   +9 more
wiley   +1 more source

Translational prioritization of strategies to overcome poly ADP-ribose polymerase inhibitor resistance in breast cancer based on systematic review of preclinical evidence. [PDF]

Discov Oncol
Shen K, Cai L.
europepmc   +1 more source

Genetic Evolution in BRCA1‐Associated Breast Cancer Reveals Early Driver Mutations Shaping Tumor Features and Prognosis

Cancer Science, Volume 117, Issue 10, Page 2863-2876, October 2026.
Multi‐region sequencing of 57 BRCA1‐associated breast cancers identified TP53 as the dominant initial driver, defining a triple‐negative subgroup with biallelic BRCA1 loss and elevated genomic instability. TP53 truncating mutations were enriched in BRCA1 carriers and linked to reduced HRD, EMT activation, and a trend toward worse survival.
Li Hu, Zhongwu Li, Qiting Wan, Xingyu Liao, Yaxin Zhang, Qian Liu, Xinyun Ding, Hua Meng, Yifan Wu, Jie Sun, Juan Zhang, Lu Yao, Ye Xu, Yuntao Xie   +13 more
wiley   +1 more source

Yeast as a Platform to Dissect Poly(ADP-Ribose) Polymerase Function from <i>Magnaporthe oryzae</i> and Evaluate PARP Inhibitors. [PDF]

Int J Mol Sci
Kalicharan RE, Payne N, Fernandez J.
europepmc   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Vascular Protection of Poly(ADP-ribose) Polymerase Inhibitors in the Combination Therapy With Vascular Endothelial Growth Factor Signaling Pathway Inhibitors. [PDF]

Rev Cardiovasc Med
Ma J, Li C, Wang W, Fan X, Wei T, Ma X, Wang Y, Feng C, Yu J.   +8 more
europepmc   +1 more source

SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
SIRT1, an NAD+‐dependent deacetylase, supports cognitive resilience by coordinating neuroprotection, synaptic plasticity, autophagy–lysosomal proteostasis, and mitochondrial energy homeostasis. Reduced or dysregulated SIRT1 is associated with protein aggregation, neuroinflammation, mitochondrial dysfunction, synaptic loss, and cognitive decline in ...
Jiabin Duan, Jiaqi Liu, Qingsheng Meng, Jiahao Liu, Sitian Yang, Fang Zhou, Jing Cao   +6 more
wiley   +1 more source

Protocol for synthesizing and purifying short-length poly(ADP)ribose polymer using fast protein liquid chromatography. [PDF]

STAR Protoc
Neeharika S, Hanuman DS, Rajakumara E.
europepmc   +1 more source

Poly (ADP-ribose) polymerase in yeasts: characterization and involvement in telomere maintenance. [PDF]

Nucleic Acids Res
Sepšiová R, Procházková K, Červenák F, Majerčík D, Hanáková K, Lattová E, Hajikazemi M, Zdráhal Z, Virágová S, Brzáčová Z, Paeschke K, Nosek J, Tomáška Ľ.   +12 more
europepmc   +1 more source