Results 211 to 220 of about 68,992 (261)
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Poly(etheno ADP-ribose) blocks poly(ADP-ribose) glycohydrolase activity
Biochemical and Biophysical Research Communications, 2007Poly(ADP-ribose) is a biopolymer synthesized by poly(ADP-ribose) polymerases. Recent findings suggest the possibility for modulation of cellular functions including cell death and mitosis by poly(ADP-ribose). Derivatization of poly(ADP-ribose) may be useful for investigating the effects of poly(ADP-ribose) on various cellular processes.
Masatoshi Watanabe, Mitsuko Masutani
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Poly(ADP-ribose): Historical perspective
Molecular and Cellular Biochemistry, 1994The early historical background of the discovery of poly(ADP-ribose) and the following development of science on poly(ADP-ribose) are reviewed. Fundamental knowledge on the natures of poly(ADP-ribose), poly(ADP-ribose) polymerase and enzymes degrading poly(ADP-ribose) are summarized with brief description on the methodology for their purification and ...
Masanao Miwa +2 more
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Poly(ADP‐ribose) and carcinogenesis
Genes, Chromosomes and Cancer, 2003AbstractPoly(ADP‐ribose) and poly(ADP‐ribose) polymerase (PARP) were discovered about 40 years ago, but their significance was not well elucidated until recently. In the early stage of the history of PARP, the presence of antibodies in the sera of human patients with lupus erythematosus indicated its natural occurrence.
Mitsuko, Masutani +2 more
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The Use of Biotinylated Poly(ADP-Ribose) for Studies on Poly(ADP-Ribose)-Protein Interaction
Analytical Biochemistry, 1994Poly(ADP-ribose) is routinely detected by the use of radioactive polymers formed from labeled substrates. In this report a simple and time-saving method for the biotinylation and the detection of poly(ADP-ribose) on blots is described. The polymer modified by light-induced reaction with photobiotin was colorimetrically detected and quantified, using ...
F M, Narendja, G, Sauermann
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Trapping Poly(ADP-Ribose) Polymerase
The Journal of Pharmacology and Experimental Therapeutics, 2015Recent findings indicate that a major mechanism by which poly(ADP-ribose) polymerase (PARP) inhibitors kill cancer cells is by trapping PARP1 and PARP2 to the sites of DNA damage. The PARP enzyme-inhibitor complex "locks" onto damaged DNA and prevents DNA repair, replication, and transcription, leading to cell death.
Yuqiao, Shen +2 more
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The Life History of Poly(ADP-ribose)
2020We present arguments and data in support of the following sequence of events in ghost cells. Poly(ADP-ribose, ADPR) synthetase, activated by binding to DNA at a break or other anomaly, synthesizes chains of polymer upon itself, adding new residues at the proximal 1" terminus of the growing chain.
M, Ikejima +4 more
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Poly(ADP-Ribose) Polymerase Inhibitors
Current Medicinal Chemistry, 2003Poly(ADP-ribose) polymerase-1 (PARP-1) is the principal member of the PARP enzyme family consisting of PARP-1 and several recently identified novel poly(ADP-ribosyl)ating enzymes. PARP-1 functions as a DNA damage sensor and signalling molecule. Upon binding to DNA breaks, activated PARP cleaves NAD(+) into nicotinamide and ADP-ribose and polymerizes ...
Garry J, Southan, Csaba, Szabó
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Biotin-Labeling of Poly(ADP-ribose) in Poly(ADP-ribose)-Protein Interactions
1996Methods are described for the preparation of poly(ADP-ribose) and for the preparation of biotinylated poly(ADP-ribose). Poly(ADP-ribose) is covalently modified to its biotinylated derivative by light-induced reaction of photobiotin with the polymer.
Frank M. Narendja, Georg Sauermann
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The Histochemical Journal, 1996
Poly(ADP-ribose) polymerase catalyses the formation of ADP-ribose polymers covalently attached to various nuclear proteins, using NAD+ as substrate. The activity of this enzyme is strongly stimulated upon binding to DNA single or double strand breaks. Poly(ADP-ribosyl)ation is an immediate cellular response to DNA damage and is thought to be involved ...
J H, Küpper +3 more
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Poly(ADP-ribose) polymerase catalyses the formation of ADP-ribose polymers covalently attached to various nuclear proteins, using NAD+ as substrate. The activity of this enzyme is strongly stimulated upon binding to DNA single or double strand breaks. Poly(ADP-ribosyl)ation is an immediate cellular response to DNA damage and is thought to be involved ...
J H, Küpper +3 more
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New Insights into the Roles of NAD+-Poly(ADP-ribose) Metabolism and Poly(ADP-ribose) Glycohydrolase
Current Protein & Peptide Science, 2016Accumulating evidence has suggested the fundamental functions of NAD+-poly(ADP-ribose) metabolism in cellular and physiological processes, including energy homeostasis, signal transduction, DNA transaction, genomic stability and cell death or survival. The NAD+ biosynthesis and poly(ADP-ribose) [(ADP-R)n] turnover are tightly controlled by several key ...
Seiichi, Tanuma +5 more
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