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Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage. [PDF]
DNA Repair (Amst)Al-Rahahleh RQ +7 more
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Targeted Treatment of Cancer by Using Conjugate Compounds with Poly(ADP-ribose) Polymerase (PARP) Inhibitors. [PDF]
ACS Med Chem LettZhou X, Liang SH.
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Versatile Modular Antibodies for Sensitive and Specific Detection of Poly-ADP-Ribose
Dauben H, Matić I.
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Importance of Poly(ADP-Ribose) Glycohydrolase in the Control of Poly(ADP-Ribose) Metabolism
Experimental Cell Research, 2001Poly(ADP-ribosyl)ation is a posttranslational modification that alters the functions of the acceptor proteins and is catalyzed by the poly(ADP-ribose) polymerase (PARP) family of enzymes. Following DNA damage, activated poly(ADP-ribose) polymerase-1 (PARP-1) catalyzes the elongation and branching of poly(ADP-ribose) (pADPr) covalently attached to ...
Laetitia Davidović +2 more
exaly +3 more sources
Poly(etheno ADP-ribose) blocks poly(ADP-ribose) glycohydrolase activity
Biochemical and Biophysical Research Communications, 2007Poly(ADP-ribose) is a biopolymer synthesized by poly(ADP-ribose) polymerases. Recent findings suggest the possibility for modulation of cellular functions including cell death and mitosis by poly(ADP-ribose). Derivatization of poly(ADP-ribose) may be useful for investigating the effects of poly(ADP-ribose) on various cellular processes.
Daisuke Maeda +2 more
exaly +3 more sources
Poly(ADP-ribose): Historical perspective
Molecular and Cellular Biochemistry, 1994The early historical background of the discovery of poly(ADP-ribose) and the following development of science on poly(ADP-ribose) are reviewed. Fundamental knowledge on the natures of poly(ADP-ribose), poly(ADP-ribose) polymerase and enzymes degrading poly(ADP-ribose) are summarized with brief description on the methodology for their purification and ...
Masanao Miwa +2 more
exaly +3 more sources
Poly(ADP-ribose) signaling in cell death
Molecular Aspects of Medicine, 2013Poly(ADP-ribosyl)ation (PARylation) is a reversible protein modification carried out by the concerted actions of poly(ADP-ribose) polymerase (PARP) enzymes and poly(ADP-ribose) (PAR) decomposing enzymes such as PAR glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3).
László Virág +2 more
exaly +4 more sources
Noncovalent Protein Interaction with Poly(ADP-Ribose)
, 2011 Compared to most common posttranslational modifications of proteins, a peculiarity of poly(ADP-ribosyl)ation is the molecular heterogeneity and complexity of the reaction product, poly(ADP-ribose) (PAR). In fact, protein-bound PAR consists of variously sized (2-200 ADP-ribose residues) linear or branched molecules, negatively charged at physiological ...
Althaus, F R, Malanga, M
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Poly(ADP‐ribose) and carcinogenesis
Genes, Chromosomes and Cancer, 2003AbstractPoly(ADP‐ribose) and poly(ADP‐ribose) polymerase (PARP) were discovered about 40 years ago, but their significance was not well elucidated until recently. In the early stage of the history of PARP, the presence of antibodies in the sera of human patients with lupus erythematosus indicated its natural occurrence.
Mitsuko, Masutani +2 more
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