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Poly(ADP-Ribose) Catabolism

1987
In eukaryotic cells, two different types of enzymes are known to attack poly-(ADP-ribose). The first enzyme, poly(ADP-ribose) glycohydrolase, cleaves ri-bose-ribose bonds of both linear and branched portions of poly(ADP-ribose) polymers by an exoglycosidic hydrolysis mode.
Felix R. Althaus, Christoph Richter
openaire   +1 more source

Poly(ADP-Ribose) in Nucleoids

1985
Nucleoids are nuclei-like structures produced from cells lysed with nonionic detergents in the presence of high salt concentrations. By this treatment, histones and most of the nonhistone proteins are removed [3]. They contain naked, histone-free DNA, RNA, and a few proteins [1]. DNA is supercoiled and attached to a cage of residual proteins and RNA [5]
Gordana Brkić   +2 more
openaire   +1 more source

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic†‡

Ca-A Cancer Journal for Clinicians, 2011
Johann de Bono   +2 more
exaly  

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

Trends in Pharmacological Sciences, 1998
Valina L. Dawson   +2 more
exaly  

Poly(ADP-ribose) (PAR) polymer is a death signal

Proceedings of the National Academy of Sciences of the United States of America, 2006
Valina L. Dawson   +2 more
exaly  

Poly(ADP-ribose) Accumulation and Enhancement of Postischemic Brain Damage in 110-kDa Poly(ADP-ribose) Glycohydrolase Null Mice

Journal of Cerebral Blood Flow and Metabolism, 2006
Laura Formentini   +2 more
exaly  

Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress

Nucleic Acids Research, 2012
Éric Paquet   +2 more
exaly  

POLY(ADP-RIBOSE) POLYMERASE GENE

2000
KOCK MICHAEL   +5 more
openaire   +4 more sources

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