Results 201 to 210 of about 68,992 (261)

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Progesterone Enhances the Sensitivity of Ovarian Cancer Cells to Poly (ADP-Ribose) Polymerase (PARP) Inhibitors by Suggesting a Role for Transcription-Replication Conflict-Related Pathways: An In Vitro Study. [PDF]

Cureus
Suizu E, Koyanagi T, Saga Y, Takahashi Y, Tamura K, Taneichi A, Takei Y, Mizukami H, Fujiwara H.   +8 more
europepmc   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Emerging Therapeutic Synergies: Combining PD-1 Inhibitors With Poly-ADP-Ribose Polymerase (PARP) Inhibitors in the Treatment of Gynecologic Cancers. [PDF]

Cureus
Mohamed Azhar MS, Loh Z, Mutamba FT, Algahiny A, Yunusa NM, Paramasevon S, Almusarhed M.   +6 more
europepmc   +1 more source

Poly(ADP-ribose) polymerase-1 in breast cancers: expression level and its association in various molecular subtypes with a focus in Africa. [PDF]

Discov Oncol
Yahaya JJ, Ngaiza AI.
europepmc   +1 more source

Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition. [PDF]

J Phys Chem B
Shanmugam N, Chatterjee S, Cisneros GA.
europepmc   +1 more source

Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage. [PDF]

DNA Repair (Amst)
Al-Rahahleh RQ, Roos WP, Saville KM, Andrews JF, Wu Z, Koczor CA, Prakash A, Sobol RW.   +7 more
europepmc   +1 more source

Targeted Treatment of Cancer by Using Conjugate Compounds with Poly(ADP-ribose) Polymerase (PARP) Inhibitors. [PDF]

ACS Med Chem Lett
Zhou X, Liang SH.
europepmc   +1 more source

Versatile Modular Antibodies for Sensitive and Specific Detection of Poly-ADP-Ribose

Dauben H, Matić I.
europepmc   +1 more source

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Importance of Poly(ADP-Ribose) Glycohydrolase in the Control of Poly(ADP-Ribose) Metabolism

Experimental Cell Research, 2001
Poly(ADP-ribosyl)ation is a posttranslational modification that alters the functions of the acceptor proteins and is catalyzed by the poly(ADP-ribose) polymerase (PARP) family of enzymes. Following DNA damage, activated poly(ADP-ribose) polymerase-1 (PARP-1) catalyzes the elongation and branching of poly(ADP-ribose) (pADPr) covalently attached to ...
Laetitia Davidović, Guy Poirier, Momchil Vodenicharov   +2 more
exaly   +3 more sources