Results 1 to 10 of about 39,389 (304)
The Antiviral Activities of Poly-ADP-Ribose Polymerases [PDF]
Viruses, 2021 The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of ...
Mathilde Malgras +4 more
doaj +3 more sources
Poly(ADP-Ribose) Polymerases in Plants and Their Human Counterparts: Parallels and Peculiarities. [PDF]
Int J Mol Sci, 2019 Poly(ADP-ribosyl)ation is a rapid and transient post-translational protein modification that was described first in mammalian cells. Activated by the sensing of DNA strand breaks, poly(ADP-ribose)polymerase1 (PARP1) transfers ADP-ribose units onto itself
Rissel D, Peiter E.
europepmc +4 more sources
RNA Regulation by Poly(ADP-Ribose) Polymerases. [PDF]
Mol Cell, 2015 Posttranscriptional regulation of RNA facilitates the fine-tuning of gene expression. It occurs through multiple pathways that include the nuclear processing of mRNA and its precursors, mRNA silencing, regulation of mRNA decay, and regulation of translation. Poly(ADP-ribose) polymerases (PARPs), enzymes that modify target proteins with ADP-ribose, play
Bock FJ, Todorova TT, Chang P.
europepmc +5 more sources
Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases [PDF]
Frontiers in Medicine, 2022 Poly (ADP-ribose) polymerases (PARPs) constitute of 17 members that are associated with divergent cellular processes and play a crucial role in DNA repair, chromatin organization, genome integrity, apoptosis, and inflammation.
Jie Tong +4 more
doaj +4 more sources
Mitotic functions of poly(ADP-ribose) polymerases. [PDF]
Biochem Pharmacol, 2019 Mitosis ensures accurate segregation of duplicated DNA through tight regulation of chromosome condensation, bipolar spindle assembly, chromosome alignment in the metaphase plate, chromosome segregation and cytokinesis. Poly(ADP-ribose) polymerases (PARPs), in particular PARP1, PARP2, PARP3, PARP5a (TNKS1), as well as poly(ADP-ribose) glycohydrolase ...
Slade D.
europepmc +5 more sources
Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro. [PDF]
Nucleic Acids Res, 2016 Poly(ADP-ribose) polymerases (PARPs/ARTDs) use nicotinamide adenine dinucleotide (NAD+) to catalyse the synthesis of a long branched poly(ADP-ribose) polymer (PAR) attached to the acceptor amino acid residues of nuclear proteins. PARPs act on single- and
Talhaoui I +10 more
europepmc +2 more sources
Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity. [PDF]
Microbiol Mol Biol Rev, 2019 The literature review presented here details recent research involving members of the poly(ADP-ribose) polymerase (PARP) family of proteins. Among the 17 recognized members of the family, the human enzyme PARP1 is the most extensively studied, resulting ...
Brady PN, Goel A, Johnson MA.
europepmc +2 more sources
New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases. [PDF]
Chem Rev, 2015 In 1963, Chambon et al. reported the detection of a nicotinamide mononucleotide-activated, DNA-dependent enzymatic activity in rat liver extracts that catalyzed the synthesis of a polyadenylic acid.1 The product of this reaction was later identified as ...
Ryu KW, Kim DS, Kraus WL.
europepmc +2 more sources
Role of poly(ADP-ribose) polymerases in male reproduction. [PDF]
Spermatogenesis, 2013 Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes involved in a wide variety of biological processes, including DNA repair and maintenance of genomic stability following genotoxic stress, and regulates the expression of various proteins at the
Celik-Ozenci C, Tasatargil A.
europepmc +2 more sources
Metabolic roles of poly(ADP-ribose) polymerases [PDF]
Seminars in Cell & Developmental Biology, 2017 Poly(ADP-ribosyl)ation (PARylation) is an evolutionarily conserved reaction that had been associated with numerous cellular processes such as DNA repair, protein turnover, inflammatory regulation, aging or metabolic regulation. The metabolic regulatory tasks of poly(ADP-ribose) polymerases (PARPs) are complex, it is based on the regulation of metabolic
Vida, András +3 more
openaire +4 more sources