Results 31 to 40 of about 15,233 (264)

Poly(ADP-ribose) Polymerase Null Mouse Cells Synthesize ADP-ribose Polymers [PDF]

Journal of Biological Chemistry, 1998
Poly(ADP-ribose) polymerase (PARP) (EC 2.4.2.30), the only enzyme known to synthesize ADP-ribose polymers from NAD+, is activated in response to DNA strand breaks and functions in the maintenance of genomic integrity. Mice homozygous for a disrupted gene encoding PARP are viable but have severe sensitivity to gamma-radiation and alkylating agents.
W M, Shieh, J C, Amé, M V, Wilson, Z Q, Wang, D W, Koh, M K, Jacobson, E L, Jacobson   +6 more
openaire   +2 more sources

ADP-ribosylation: from molecular mechanisms to human disease [PDF]

Genetics and Molecular Biology
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and ...
Nicolas C. Hoch, Luis M. Polo
doaj   +2 more sources

DNA repair in cancer: emerging targets for personalized therapy [PDF]

, 2014
Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity.
Abbotts, Rachel, Madhusudan, Srinivasan, Thompson, Nicola   +2 more
core   +3 more sources

Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives. [PDF]

PLoS ONE, 2012
Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases.
Julie A Tucker, Neil Bennett, Claire Brassington, Stephen T Durant, Giles Hassall, Geoff Holdgate, Mark McAlister, J Willem M Nissink, Caroline Truman, Martin Watson   +9 more
doaj   +1 more source

Novel modulators of poly(ADP-ribose) polymerase [PDF]

Trends in Pharmacological Sciences, 2006
The nuclear enzyme poly(ADP-ribose) polymerase (PARP)-1 has an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP have entered clinical testing as cytoprotective agents in cardiovascular diseases and as adjunct antitumor therapeutics.
Csaba, Szabo, Pal, Pacher, Raymond A, Swanson   +2 more
openaire   +2 more sources

PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes

Adipocyte, 2022
PARP12 is a member of poly-ADP-ribosyl polymerase (PARPs), which has been characterized for its antiviral function. Yet its physiological implication in adipocytes remains unknown.
Fan Hu, Chang Li, Yafen Ye, Xuhong Lu, Miriayi Alimujiang, Ningning Bai, Jingjing Sun, Xiaojing Ma, Xiaohua Li, Ying Yang   +9 more
doaj   +1 more source

The Dichotomy of the Poly(ADP-Ribose) Polymerase-Like Thermozyme from Sulfolobus solfataricus

Challenges, 2018
The first evidence of an ADP-ribosylating activity in Archaea was obtained in Sulfolobus solfataricus(strain MT-4) where a poly(ADP-ribose) polymerase (PARP)-like thermoprotein, defined with the acronymous PARPSso, was found.
Maria Rosaria Faraone Mennella
doaj   +1 more source

Methylation status of Dnmt1 promoter depends on poly(ADP-ribosy)lation [PDF]

, 2007
Research is focused on CpG islands and on the mechanism that poly(ADP-ribosyl)ation uses to defend the unmethylated state of these important DNA sequences which are located in the promoter regions of the housekeeping genes having a role of transcription ...
Zampieri, Michele
core   +1 more source

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

Nature Communications, 2018
Poly(ADP-ribose) polymerases (PARPs) catalyse ADP-ribose posttranslational modifications using NAD+ as a substrate. Here, the authors present the crystal structure of PARP-1 bound to the non-hydrolyzable NAD+ analog BAD and provide insights into the ...
Marie-France Langelier, Levani Zandarashvili, Pedro M. Aguiar, Ben E. Black, John M. Pascal   +4 more
doaj   +1 more source

VERO cells harbor a poly-ADP-ribose belt partnering their epithelial adhesion belt [PDF]

PeerJ, 2014
Poly-ADP-ribose (PAR) is a polymer of up to 400 ADP-ribose units synthesized by poly-ADP-ribose-polymerases (PARPs) and degraded by poly-ADP-ribose-glycohydrolase (PARG).
Laura Lafon-Hughes, Salomé C. Vilchez Larrea, Alejandra Kun, Silvia H. Fernández Villamil   +3 more
doaj   +2 more sources