Results 91 to 100 of about 3,094 (198)

New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage

BMC Plant Biology, 2019
Background Poly (ADP-ribosyl) ation (PARylation) is an important posttranslational modification that regulates DNA repair, gene transcription, stress responses and developmental processes in multicellular organisms.
Zongying Gu, Weiyang Pan, Wei Chen, Qichao Lian, Qiao Wu, Zeyu Lv, Xuan Cheng, Xiaochun Ge   +7 more
doaj   +1 more source

Inhibition of GSDMD Activates Poly(ADP-ribosyl)ation and Promotes Myocardial Ischemia-Reperfusion Injury. [PDF]

Oxid Med Cell Longev, 2022
Zhang ZH, Zhang ZG, Chen MW, Yang Y, Li RJ, Xu JJ, Yang C, Li YY, Chen HW, Liu SX, Li YL, Luo P, Liu YJ, Chen WB, Shan ZG, Huang ZR.   +15 more
europepmc   +1 more source

Regulation of p53 Sequence-specific DNA-binding by Covalent Poly(ADP-ribosyl)ation [PDF]

, 2001
Hilda Mendoza‐Alvarez, Rafael Álvarez-González   +1 more
openalex   +1 more source

HDAC inhibitors suppress protein poly(ADP-ribosyl)ation and DNA repair protein levels and phosphorylation status in hematologic cancer cells: implications for their use in combination with PARP inhibitors and chemotherapeutic drugs. [PDF]

Oncotarget, 2022
Valdez BC, Nieto Y, Yuan B, Murray D, Andersson BS.   +4 more
europepmc   +1 more source

NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis

Cell Reports
Summary: We identified poly(ADP-ribose) polymerase 7 (PARP7), a mono(ADP-ribosyl) transferase, as a regulator of C/EBPβ-dependent proadipogenic gene expression.
MiKayla S. Stokes, Yoon Jung Kim, Yonghyeon Kim, Sneh Koul, Shu-Ping Chiu, Chenqian Liu, Morgan Dasovich, Josue Zuniga, Tulip Nandu, Dan Huang, Thomas P. Mathews, Ashley Solmonson, Cristel V. Camacho, W. Lee Kraus   +13 more
doaj   +1 more source

The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy. [PDF]

Acta Pharm Sin B, 2021
Li Z, Guo Z, Lan R, Cai S, Lin Z, Li J, Wang J, Li Z, Liu P.   +8 more
europepmc   +1 more source

The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context. [PDF]

Sci Rep, 2021
Kutuzov MM, Belousova EA, Kurgina TA, Ukraintsev AA, Vasil'eva IA, Khodyreva SN, Lavrik OI.   +6 more
europepmc   +1 more source

Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP‐ribosyl)ation and PARP‐1 activity [PDF]

, 2007
Tanja Schwerdtle, Ingrit Hamann, Gunnar Jahnke, Ingo Walter, Constanze Richter, Jason L. Parsons, Grigory L. Dianov, A. Hartwig   +7 more
openalex   +1 more source

PARG Mutation Uncovers Critical Structural Determinant for Poly(ADP-Ribose) Hydrolysis and Chromatin Regulation in Embryonic Stem Cells

Cells
Poly(ADP-ribosyl)ation is a crucial posttranslational modification that governs gene expression, chromatin remodeling, and cellular homeostasis. This dynamic process is mediated by the opposing activities of poly(ADP-ribose) polymerases (PARPs), which ...
Yaroslava Karpova, Sara Piatz, Guillaume Bordet, Alexei V. Tulin   +3 more
doaj   +1 more source

PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPARγ in cardiac fibroblasts [PDF]

, 2008
Dan Huang, Chongzhe Yang, Yan Wang, Yuhua Liao, Kai Huang   +4 more
openalex   +1 more source