Results 91 to 100 of about 6,825 (206)

Emerging Radiopharmaceuticals Beyond FDG for Ovarian Cancer: A Review of Advances in Nuclear Medicine

Cancer Medicine, Volume 14, Issue 17, September 2025.
Emerging radiopharmaceuticals in nuclear medicine could improve ovarian cancer diagnosis and staging, while also enabling assessment of treatment response, therapy resistance, and suitability for targeted therapies. ABSTRACT Aims This review summarizes the role and future prospects of nuclear medicine in ovarian cancer, focusing on novel ...
Mara M. K. Veenstra, Sophie Veldhuijzen van Zanten, Erik Vegt, Ingrid A. Boere, Heleen J. van Beekhuizen, Julie Nonnekens, Frederik A. Verburg, Maarten G. J. Thomeer   +7 more
wiley   +1 more source

LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin

Genome Biology, 2022
Background Single-stranded DNA (ssDNA) coated with replication protein A (RPA) acts as a key platform for the recruitment and exchange of genome maintenance factors in DNA damage response. Yet, how the formation of the ssDNA-RPA intermediate is regulated
Kaiwen Bao, Qi Zhang, Shuai Liu, Nan Song, Qiushi Guo, Ling Liu, Shanshan Tian, Jihui Hao, Yi Zhu, Kai Zhang, Ding Ai, Jie Yang, Zhi Yao, Roland Foisner, Lei Shi   +14 more
doaj   +1 more source

The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and Beyond

Cells, 2019
Poly(ADP-ribosyl)ation (PARylation) is an essential post-translational modification catalyzed by poly(ADP-ribose) polymerase (PARP) enzymes. Poly(ADP-ribose) polymerase 1 (PARP1) is a well-characterized member of the PARP family.
Yueshuang Ke, Chenxin Wang, Jiaqi Zhang, Xiyue Zhong, Ruoxi Wang, Xianlu Zeng, Xueqing Ba   +6 more
doaj   +1 more source

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients. [PDF]

, 2015
BACKGROUND: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell ...
Aittomäki, Kristiina, Alnæs, Grethe G, Behrens, Sabine, Blomqvist, Carl, Bolla, Manjeet K., Børresen-Dale, Anne-Lise, Chang-Claude, Jenny, Couch, Fergus J., Dunning, Alison M., Easton, Doug F, Fagerholm, Rainer, Flesch-Janys, Dieter, Hall, Per, Hamann, Ute, Hartikainen, Jaana M., Hollestelle, Antoinette, Hooning, Maartje J, Humphreys, Keith, Jager, Agnes, Kabisch, Maria, Kataja, Vesa, Kosma, Veli-Matti, Kristensen, Vessela, Lambrechts, Diether, Li, Jingmei, Liu, Jianjun, Mannermaa, Arto, Margolin, Sara, Michailidou, Kyriaki, Nevanlinna, Heli, Nord, Silje, Pharoah, Paul, Popanda, Odilia, Purrington, Kristen S, Rhenius, Valerie, Schildkraut, Joellen M, Schmezer, Peter, Schmidt, Marjanka K., Seibold, Petra, Seynaeve, Caroline, Shah, Mitul, Torres, Diana, Ulmer, Hans-Ulrich, Wang, Qin, Wildiers, Hans   +44 more
core   +4 more sources

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Aging Cell, Volume 24, Issue 9, September 2025.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini, Laura Colman, Eduardo Palmieri, Jessica L. Strange, Sonu Kashyap, Bing Han, Andres Benitez‐Rosendo, Gina L. Ciccio Lopez, Sara Peixoto Rabelo, Shreyartha Mukherjee, Gustavo H. de Souza, John Varga, Ralph G. Meyer, Mirella L. Meyer‐Ficca, Eduardo N. Chini   +14 more
wiley   +1 more source

Poly (ADP‐Ribose) Glycohydrolase‐Dependent dePARylation of PCNA Is Essential for DNA Replication

The FASEB Journal, Volume 39, Issue 16, 31 August 2025.
The schematic illustration of PARG‐mediated dePARylation in DNA replication. In the normal physiological condition, PARG functions as an eraser to remove PAR from PCNA and promote the interaction between FEN1 and PCNA (A). Interruption of PARG results in the accumulation of PARs in DNA replication sites, represses the interaction between PCNA and FEN1,
Zhenzhen Yan, Qianxi Feng, Xiuhuan Jiang, Xiaoru Han, Zichang Qiao, Yaguang Wang, Xiaoyun Yang, Xiuhua Liu, Xinying Cheng, Shuai Guo, Hongyan Li, Chen Wu   +11 more
wiley   +1 more source

Targeting dePARylation for cancer therapy

Cell & Bioscience, 2020
Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects ...
Muzaffer Ahmad Kassab, Lily L. Yu, Xiaochun Yu   +2 more
doaj   +1 more source

Proximity in chromatin : opportunities for innovations [PDF]

, 2014
Mammalian chromosomes extensively communicate with each other via long-range chromatin interactions. These interactions are mostly mediated by proteins, which work as teams to control genes in the cells.
Yammine, Samer
core   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, Volume 24, Issue 8, August 2025.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

PARP-1 regulates DNA repair factor availability. [PDF]

, 2018
PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth, Brand, Lucas J, Cendon-Florez, Ylenia, Chand, Saswati N., de Leeuw, Renée, Dicker, Adam, MD, PhD, Dylgjeri, Emanuela, Evans, Joseph, Feng, Felix Y, Gallagher, Peter, Gaur, Sanchaika, Gomella, Leonard G, Gordon, Nicolas, Han, Sumin, Huang, Fangjin, Kelly, William Kevin, Knudsen, Beatrice, Knudsen, Karen E, Lallas, Costas D, Leiby, Benjamin E, Mandigo, Amy C., McCann, Jennifer J, McCue, Peter, McNair, Christopher, Parsons, Theodore, Poudel Neupane, Neermala, Raj, Ganesh V, Schiewer, M J, Shafi, Ayesha A, Trabulsi, Edouard J, Visakorpi, Tapio, Zhao, Shuang G   +31 more
core   +2 more sources