Results 91 to 100 of about 602,119 (146)

PARG Mutation Uncovers Critical Structural Determinant for Poly(ADP-Ribose) Hydrolysis and Chromatin Regulation in Embryonic Stem Cells

Cells
Poly(ADP-ribosyl)ation is a crucial posttranslational modification that governs gene expression, chromatin remodeling, and cellular homeostasis. This dynamic process is mediated by the opposing activities of poly(ADP-ribose) polymerases (PARPs), which ...
Yaroslava Karpova, Sara Piatz, Guillaume Bordet, Alexei V. Tulin   +3 more
doaj   +1 more source

Poly(ADP-ribosyl)ation enhances HuR oligomerization and contributes to pro-inflammatory gene mRNA stabilization. [PDF]

Cell Mol Life Sci, 2021
Ke Y, Lv X, Fu X, Zhang J, Bohio AA, Zeng X, Hao W, Wang R, Boldogh I, Ba X.   +9 more
europepmc   +1 more source

PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress

Nature Communications
PARP2 is a DNA-dependent ADP-ribosyl transferase (ARTs) enzyme with Poly(ADP-ribosyl)ation activity that is triggered by DNA breaks. It plays a role in the Base Excision Repair pathway, where it has overlapping functions with PARP1.
Daniela Muoio, Natalie Laspata, Rachel L. Dannenberg, Caroline Curry, Simone Darkoa-Larbi, Mark Hedglin, Shikhar Uttam, Elise Fouquerel   +7 more
doaj   +1 more source

Poly(ADP-ribosyl)ation of histone H1 correlates with internucleosomal DNA fragmentation during apoptosis

, 1996
The biochemical role of poly(ADP-ribosyl)ation on internucleosomal DNA fragmentation associated with apoptosis was investigated in HL 60 human premyelocytic leukemia cells.
Yoon, Yoo Sik, Choi, Kyung Hee, Kim, Young Sang, Kang, Kae Won, Joe, Cheol O, Kim, Jin Woo   +5 more
core   +1 more source

Molecular mechanism of poly(ADP-ribosyl)ation catalyzed by human poly(ADP-ribose) polymerase-1

, 2015
Human poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme which catalyzes protein poly(ADP-ribosyl)ation upon binding to DNA. NAD+ is used as a co-substrate in the reaction via iterative transfer of its ADP-ribose moiety to acceptor ...
Lin, Ke-Yi
core  

Modulation of chromatin structure by poly(ADP-ribosyl)ation

, 1988
Poly(ADP-ribose) polymerase is a nuclear enzyme that is highly conserved in eucaryotes. Its activity is totally dependent on the presence of DNA containing single or double stranded breaks.
Poirier, G G, Murcia, G,, Huletsky, A
core   +1 more source

Additional evidence for the involvement of endonuclease P23 in necrosis [PDF]

Archives of Biological Sciences, 2007
Grdović Nevena, Vidaković Melita, Mihailović Mirjana, Dinić Svetlana, Uskoković Aleksandra, Martinović Vesna, Arambašić Jelena, Grigorov Ilijana, Ivanović-Matić Svetlana, Bogojević Desanka, Petrović M., Poznanović G.   +11 more
doaj   +1 more source

Poly(ADP-ribosyl)ation: A posttranslational protein modification linked with genome protection and mammalian longevity

, 2000
Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalysed by the 113-kDa enzyme poly(ADP-ribose) polymerase-1 (PARP-1) and, to a lesser extent, by several other recently described polypeptides.
Burkle A
core   +2 more sources

Poly(ADP-ribosyl)ation mediates early phase histone eviction at DNA lesions. [PDF]

Nucleic Acids Res, 2020
Yang G, Chen Y, Wu J, Chen SH, Liu X, Singh AK, Yu X.   +6 more
europepmc   +1 more source

Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation. [PDF]

Sci Rep, 2020
Matta E, Kiribayeva A, Khassenov B, Matkarimov BT, Ishchenko AA.   +4 more
europepmc   +1 more source