Results 91 to 100 of about 1,124 (169)

Poly(ADP-ribosyl)ation of histone H1 correlates with internucleosomal DNA fragmentation during apoptosis

, 1996
The biochemical role of poly(ADP-ribosyl)ation on internucleosomal DNA fragmentation associated with apoptosis was investigated in HL 60 human premyelocytic leukemia cells.
Yoon, Yoo Sik, Choi, Kyung Hee, Kim, Young Sang, Kang, Kae Won, Joe, Cheol O, Kim, Jin Woo   +5 more
core  

Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation

, 2006
Chromatin-modifying factors play key roles in transcription, DNA replication and DNA repair. Post-translational modification of these proteins is largely responsible for regulating their activity. The FACT (facilitates chromatin transcription) complex, a
Hsiao-ting Wang, Jing-yi Huang, Sheng-chung Lee, Ya-ling Chang, Wan-ting Chuang, Wei-hao Chen   +5 more
core  

Deltex family E3 ligases specifically ubiquitinate the terminal ADP-ribose of poly(ADP-ribosyl)ation

Poly(ADP-ribose) polymerases (PARPs) are critical to regulating cellular activities, such as the response to DNA damage and cell death. PARPs catalyze a reversible post-translational modification (PTM) in the form of mono- or poly(ADP-ribosyl)ation. This
Kim, In-Kwon, Dietz, Chase, Holtzman, Michael J, Kelly, Matthew, Kasson, Samuel, Zhang, Yong   +5 more
core   +1 more source

Poly(ADP-ribosyl)ation of chromatin: kinetics of relaxation and its effect on chromatin solubility

, 1985
We have studied the kinetics of relaxation of poly(ADP-ribosyl)ated polynucleosomes produced by endogenous enzyme activity by comparing the generation of hyper(ADP-ribosyl)ated histone H1 and its effect on the chromatin structure as revealed by electron ...
Lord, A, Frechette, A, Mandel, P, Grondin, G, Poirier, G G, Aubin, R J, Huletsky, A, Murcia, G,   +7 more
core   +1 more source

Poly(ADP-ribosyl)ation and aging

Poly(ADP-ribosyl)ation is a DNA strand break-driven post-translational modification of proteins catalyzed by poly (ADP-ribose) polymerase-1 (PARP-1). with NAD+ serving as substrate.
Burkle A, Muiras ML, Beneke S
core  

NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis

Cell Reports
Summary: We identified poly(ADP-ribose) polymerase 7 (PARP7), a mono(ADP-ribosyl) transferase, as a regulator of C/EBPβ-dependent proadipogenic gene expression.
MiKayla S. Stokes, Yoon Jung Kim, Yonghyeon Kim, Sneh Koul, Shu-Ping Chiu, Chenqian Liu, Morgan Dasovich, Josue Zuniga, Tulip Nandu, Dan Huang, Thomas P. Mathews, Ashley Solmonson, Cristel V. Camacho, W. Lee Kraus   +13 more
doaj   +1 more source

Poly(ADP-ribosyl)ation: A posttranslational protein modification linked with genome protection and mammalian longevity

, 2000
Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalysed by the 113-kDa enzyme poly(ADP-ribose) polymerase-1 (PARP-1) and, to a lesser extent, by several other recently described polypeptides.
Burkle A
core  

Poly(ADP-ribosyl)ation of FOXP3 protein mediated by PARP-1 protein regulates the function of regulatory T cells

, 2015
Poly(ADP-ribose) polymerase 1 (PARP-1) is an ADP-ribosylating enzyme participating in diverse cellular functions. The roles of PARP-1 in the immune system, however, have not been well understood.
Chen, WanJun, Li, Dan, Li, Bin, Hu, Hui, Nie, Jia, Chen, Zuojia, Wang, Shuaiwei, Luo, Xuerui   +7 more
core   +1 more source

Disordered Protein Tail Is Wagging Poly(ADP-ribosyl)ation

International Journal of Molecular Sciences
Intrinsically disordered regions (IDRs) are present in nearly all proteins, often accounting for more than 40% of their amino acid sequence. Unlike structured domains, IDRs lack sequence or structural conservation across species while maintaining conserved biological functions.
Guillaume Bordet, Yaroslava Karpova, Saraynia Espeseth, Gavin Mitzel, Zachary Bigelow, Alexei V. Tulin   +5 more
openaire   +2 more sources

PARG Mutation Uncovers Critical Structural Determinant for Poly(ADP-Ribose) Hydrolysis and Chromatin Regulation in Embryonic Stem Cells

Cells
Poly(ADP-ribosyl)ation is a crucial posttranslational modification that governs gene expression, chromatin remodeling, and cellular homeostasis. This dynamic process is mediated by the opposing activities of poly(ADP-ribose) polymerases (PARPs), which ...
Yaroslava Karpova, Sara Piatz, Guillaume Bordet, Alexei V. Tulin   +3 more
doaj   +1 more source