Results 71 to 80 of about 1,124 (169)
TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging
Journal of Medical Virology, Volume 97, Issue 11, November 2025.ABSTRACT Torquetenovirus (TTV) is a prevalent virus whose clinical significance remains unclear, potentially linked to immunosenescence. This study examines TTV species in relation to immune impairment, inflammation, and cellular stress response in aging.
Federica Novazzi +35 more
wiley +1 more source
Cancer Medicine, Volume 14, Issue 17, September 2025.Emerging radiopharmaceuticals in nuclear medicine could improve ovarian cancer diagnosis and staging, while also enabling assessment of treatment response, therapy resistance, and suitability for targeted therapies. ABSTRACT Aims This review summarizes the role and future prospects of nuclear medicine in ovarian cancer, focusing on novel ...
Mara M. K. Veenstra +7 more
wiley +1 more source
LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin
Genome Biology, 2022 Background Single-stranded DNA (ssDNA) coated with replication protein A (RPA) acts as a key platform for the recruitment and exchange of genome maintenance factors in DNA damage response. Yet, how the formation of the ssDNA-RPA intermediate is regulated
Kaiwen Bao +14 more
doaj +1 more source
The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and Beyond
Cells, 2019 Poly(ADP-ribosyl)ation (PARylation) is an essential post-translational modification catalyzed by poly(ADP-ribose) polymerase (PARP) enzymes. Poly(ADP-ribose) polymerase 1 (PARP1) is a well-characterized member of the PARP family.
Yueshuang Ke +6 more
doaj +1 more source
Aging Cell, Volume 24, Issue 9, September 2025.Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini +14 more
wiley +1 more source
Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins
, 2013 Gene expression is intricately regulated at the post-transcriptional level by RNA-binding proteins (RBPs) via their interactions with pre-messenger RNA (pre-mRNA) and mRNA during development.
Alexei Tulin, Yingbiao Ji
core +1 more source
, 2022 Poly(ADP-ribosyl)ation is a post-translational modification of proteins by transferring poly(ADP-ribose) (PAR) to acceptor proteins by the action of poly(ADP-ribose) polymerase (PARP).
Momoko Kita +11 more
core +1 more source
Poly (ADP‐Ribose) Glycohydrolase‐Dependent dePARylation of PCNA Is Essential for DNA Replication
The FASEB Journal, Volume 39, Issue 16, 31 August 2025.The schematic illustration of PARG‐mediated dePARylation in DNA replication. In the normal physiological condition, PARG functions as an eraser to remove PAR from PCNA and promote the interaction between FEN1 and PCNA (A). Interruption of PARG results in the accumulation of PARs in DNA replication sites, represses the interaction between PCNA and FEN1,
Zhenzhen Yan +11 more
wiley +1 more source
Targeting dePARylation for cancer therapy
Cell & Bioscience, 2020 Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects ...
Muzaffer Ahmad Kassab +2 more
doaj +1 more source
Aging Cell, Volume 24, Issue 8, August 2025.Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji +15 more
wiley +1 more source