Results 71 to 80 of about 602,119 (146)

LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin

Genome Biology, 2022
Background Single-stranded DNA (ssDNA) coated with replication protein A (RPA) acts as a key platform for the recruitment and exchange of genome maintenance factors in DNA damage response. Yet, how the formation of the ssDNA-RPA intermediate is regulated
Kaiwen Bao, Qi Zhang, Shuai Liu, Nan Song, Qiushi Guo, Ling Liu, Shanshan Tian, Jihui Hao, Yi Zhu, Kai Zhang, Ding Ai, Jie Yang, Zhi Yao, Roland Foisner, Lei Shi   +14 more
doaj   +1 more source

PARP Activity Is Essential for Retinal Photoreceptor Survival in the Human Homologous RhoI255del Mouse Model for Autosomal Dominant Retinitis Pigmentosa

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
Inhibition of PARP with different selective inhibitors (PARPi). Olaparib (Ola), Saruparib (Sar), INO1001 (INO), and nicotinamide (NAM) all increase photoreceptor cell death in the RhoI255del/+ mouse model for autosomal dominant retinitis pigmentosa.
Yu Zhu, Azdah Hamed A. Fallatah, Kangwei Jiao, Mathias W. Seeliger, François Paquet‐Durand   +4 more
wiley   +1 more source

The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and Beyond

Cells, 2019
Poly(ADP-ribosyl)ation (PARylation) is an essential post-translational modification catalyzed by poly(ADP-ribose) polymerase (PARP) enzymes. Poly(ADP-ribose) polymerase 1 (PARP1) is a well-characterized member of the PARP family.
Yueshuang Ke, Chenxin Wang, Jiaqi Zhang, Xiyue Zhong, Ruoxi Wang, Xianlu Zeng, Xueqing Ba   +6 more
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, Volume 599, Issue 22, Page 3355-3368, November 2025.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT Torquetenovirus (TTV) is a prevalent virus whose clinical significance remains unclear, potentially linked to immunosenescence. This study examines TTV species in relation to immune impairment, inflammation, and cellular stress response in aging.
Federica Novazzi, Pietro Giorgio Spezia, Francesca Drago Ferrante, Angelo Paolo Genoni, Paolo Antonio Grossi, Nicasio Mancini, Marco Malavolta, Marta Balietti, Francesco Piacenza, Serena Marcozzi, Carlo Fortunato, Gretta Veronica Badillo Pazmay, Laura Cianfruglia, Alexander Bürkle, María Moreno‐Villanueva, Martijn E. T. Dollé, Eugène Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Michele Zampieri, Paola Caiafa, Fabio Ciccarone, Anna Reale, Birgit Weinberger, Ewa Sikora, Florence Debacq‐Chainiaux, Wolfgang Stuetz, Mikko Hurme, P. Eline Slagboom, Jürgen Bernhardt, Fabiola Olivieri, Fabio Filippini, Fabrizio Maggi, Robertina Giacconi   +35 more
wiley   +1 more source

Emerging Radiopharmaceuticals Beyond FDG for Ovarian Cancer: A Review of Advances in Nuclear Medicine

Cancer Medicine, Volume 14, Issue 17, September 2025.
Emerging radiopharmaceuticals in nuclear medicine could improve ovarian cancer diagnosis and staging, while also enabling assessment of treatment response, therapy resistance, and suitability for targeted therapies. ABSTRACT Aims This review summarizes the role and future prospects of nuclear medicine in ovarian cancer, focusing on novel ...
Mara M. K. Veenstra, Sophie Veldhuijzen van Zanten, Erik Vegt, Ingrid A. Boere, Heleen J. van Beekhuizen, Julie Nonnekens, Frederik A. Verburg, Maarten G. J. Thomeer   +7 more
wiley   +1 more source

Targeting dePARylation for cancer therapy

Cell & Bioscience, 2020
Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects ...
Muzaffer Ahmad Kassab, Lily L. Yu, Xiaochun Yu   +2 more
doaj   +1 more source

Does poly(ADP-ribosyl)ation regulate the DNA methylation pattern?

, 1997
The existence of a possible correlation between poly(ADP-ribosyl)ation and DNA methylation processes was investigated. In vivo and in vitro experiments were carried out on L929 mouse fibroblasts preincubated for 24 h with or without 3-aminobenzamide, a ...
REALE, Anna, STROM, Roberto, CAIAFA, Paola, PERILLI M., D'ERME, Maria, PERILLI M, ZARDO, GIUSEPPE   +6 more
core   +1 more source

The Dichotomy of the Poly(ADP-Ribose) Polymerase-Like Thermozyme from Sulfolobus solfataricus

Challenges, 2018
The first evidence of an ADP-ribosylating activity in Archaea was obtained in Sulfolobus solfataricus(strain MT-4) where a poly(ADP-ribose) polymerase (PARP)-like thermoprotein, defined with the acronymous PARPSso, was found.
Maria Rosaria Faraone Mennella
doaj   +1 more source

The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin. A role of poly(ADP-ribosyl)ation on core nucleosome structure

, 1989
International audienceThe effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin was analyzed by gel electrophoresis, electron microscopy, and velocity sedimentation.
Lamarre, D, Murcia, G, De, Muller, S, Poirier, G G, Ménard, L, Hengartner, M, Huletsky, A   +6 more
core   +2 more sources