Results 61 to 70 of about 6,825 (206)

Pan‐Modification Proteoformics: A Framework for Decoding Proteomic Complexity in Health and Disease

Barrier Immunity, Volume 2, Issue 1, Page 32-49, March 2026.
Post‐translational modification (PTM) diversity represents a central regulatory layer that drives protein functional complexity. Classical PTMs (phosphorylation, acetylation, ubiquitination, and glycosylation) and emerging PTMs (SUMOylation, lipidation, and ADP‐ribosylation) form dynamic modification codes that govern signaling, metabolism, and ...
Yang Yang, Wenzhi Guo, Jing‐Hua Yang
wiley   +1 more source

Biological Roles of Mono- and Poly (ADP-Ribosyl) ation

Journal of Nutritional Science and Vitaminology, 1992
Biological roles of mono- and poly (ADP-ribosyl) ation reactions are reviewed, along with analysis of functional sequences of poly(ADP-ribose) synthetase and inhibitors of the synthetase compared with mono (ADP-ribosyl) transferase.
K, Ueda, M, Banasik, I, Saito, T, Kido, B R, Das, N A, Abed, H, Komura   +6 more
openaire   +3 more sources

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions [PDF]

Biochemical Journal, 1999
Poly(ADP-ribosyl)ation is a post-translational modification of proteins. During this process, molecules of ADP-ribose are added successively on to acceptor proteins to form branched polymers. This modification is transient but very extensive in vivo, as polymer chains can reach more than 200 units on protein acceptors.
D, D'Amours, S, Desnoyers, I, D'Silva, G G, Poirier   +3 more
openaire   +2 more sources

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, Volume 600, Issue 4, Page 418-438, February 2026.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells

Translational Oncology, 2022
The PARP-1 expression level and poly (ADP-ribosyl)ation activity in cancer markedly affect the therapeutic outcome. Nicaraven, a free radical scavenger has been found to inhibit PARP, but the effect on cancer cells is still unclear.
Lina Abdelghany, Tsuyoshi Kawabata, Shinji Goto, Keiichi Jingu, Tao-Sheng Li   +4 more
doaj   +1 more source

Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation. [PDF]

Cell Death Differ, 2015
The transcription factor adenovirus E2 promoter-binding factor (E2F)-1 normally enhances cell-cycle progression, but it also induces apoptosis under certain conditions, including DNA damage and serum deprivation. Although DNA damage facilitates the phosphorylation and stabilization of E2F1 to trigger apoptosis, how serum starvation renders cells ...
Kumari A, Iwasaki T, Pyndiah S, Cassimere EK, Palani CD, Sakamuro D.   +5 more
europepmc   +4 more sources

Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes. [PDF]

, 2019
Poly(ADP-ribose) polymerase 1 (PARP-1) is a multidomain multifunctional nuclear enzyme involved in the regulation of the chromatin structure and transcription.
Ampofo, Michelle, Boyle, Cody, Currie, Michelle, Datz, Haily, Harbin, Jonathan, Ji, Yingbiao, Johnson, Sarah J., Lodhi, Niraj, MacLeod, Brett, Patel, Shri, Pechenkina, Kate, Thomas, MD, Colin, Tulin, Alexei V., Wu, Chao   +13 more
core   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Redox Biology, 2021
Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients.
Juan Manuel Martí, Angel Garcia-Diaz, Daniel Delgado-Bellido, Francisco O'Valle, Ariannys González-Flores, Onintza Carlevaris, José Manuel Rodríguez-Vargas, Jean Christophe Amé, Françoise Dantzer, George L. King, Klaudia Dziedzic, Edurne Berra, E. de Álava, A.T. Amaral, Ester M. Hammond, F. Javier Oliver   +15 more
doaj   +1 more source