Results 61 to 70 of about 602,119 (146)

RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair

Cell Reports, 2018
Summary: The Fanconi anemia (FA) pathway is a pivotal genome maintenance network that orchestrates the repair of DNA interstrand crosslinks (ICLs). The tumor suppressors RUNX1 and RUNX3 were shown to regulate the FA pathway independent of their canonical
Lavina Sierra Tay, Vaidehi Krishnan, Haresh Sankar, Yu Lin Chong, Linda Shyue Huey Chuang, Tuan Zea Tan, Arun Mouli Kolinjivadi, Dennis Kappei, Yoshiaki Ito   +8 more
doaj   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

Mono-ADP-ribosylation, a MARylationmultifaced modification of protein, DNA and RNA: characterizations, functions and mechanisms

Cell Death Discovery
The functional alterations of proteins and nucleic acids mainly rely on their modifications. ADP-ribosylation is a NAD+-dependent modification of proteins and, in some cases, of nucleic acids.
Hao Wu, Anqi Lu, Jiuzhi Yuan, Yang Yu, Chongning Lv, Jincai Lu   +5 more
doaj   +1 more source

CCNE1 Exerts a Protective Effect on Parkinson's Disease by Regulating Ferroptosis‐Related Proteins

Brain and Behavior, Volume 15, Issue 12, December 2025.
This study provides the first molecular insight into how CCNE1 exerts neuroprotective effects through the regulation of the ferroptosis key protein PARP16, offering a novel perspective for Parkinson's disease mechanism research. ABSTRACT Background The pathogenesis of Parkinson's disease (PD) is closely linked to ferroptosis, yet the mechanism by which
Jia Fu, Jing Zhao, Na Mi, Chao Zhang, Yali Zhang, Lifen Yao   +5 more
wiley   +1 more source

Molecular mechanism of poly(ADP-ribosyl)ation catalyzed by human poly(ADP-ribose) polymerase-1 [PDF]

, 2017
Human poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme which catalyzes protein poly(ADP-ribosyl)ation upon binding to DNA. NAD+ is used as a co-substrate in the reaction via iterative transfer of its ADP-ribose moiety to acceptor ...
Lin, Ke-Yi
core   +1 more source

Poly(ADP-ribose) polymerase 1 orchestrates vascular smooth muscle cell homeostasis in arterial disease

Experimental and Molecular Medicine
Smooth muscle cells are remarkably plastic. Their reversible differentiation is required for growth and wound healing but also contributes to pathologies such as atherosclerosis and restenosis.
Wenjing Xu, Yichen Wu, Ruiqi Mao, Yujie Jia, Hao Jiang, Fengxiao Zhang, Dan Huang, Ximiao He, Cheng Wang, Kai Huang   +9 more
doaj   +1 more source

The Ageing Process Affects the Antioxidant Defences and the Poly (ADPribosyl)ation Activity in Cistus Incanus L. Leaves

Antioxidants, 2019
The ageing process in living organisms is characterised by the accumulation of several deleterious changes occurring in cells and tissues. The increase of reactive oxygen species with the advancement of age is responsible for the oxidative damage to ...
Carmen Arena, Luca Vitale, Anna Rita Bianchi, Carmela Mistretta, Ermenegilda Vitale, Costantino Parisi, Giulia Guerriero, Vincenzo Magliulo, Anna De Maio   +8 more
doaj   +1 more source

Loss‐of‐function genetic screen unveils synergistic efficacy of PARG inhibition with combined 5‐fluorouracil and irinotecan treatment in colorectal cancer

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
LOF screening identified PARG as a modulator of CRC response to FUIRI treatment. HT29 PARG‐KO cells showed increased PAR, DNA damage, apoptosis, and 5FU sensitivity. Pharmacological PARG inhibition synergised with 5FU and SN38 in CRC cell lines. HT29 PARG‐KO tumours exhibited increased sensitivity to 5FU treatment in vivo.
Cristina Queralt, Cristina Moreta‐Moraleda, Marta Costa, Ferran Grau‐Leal, Jeannine Diesch, Carla Vendrell‐Ayats, Eva Musulén, Roni H G Wright, Cristina Bugés, José Luis Manzano, Sara Cabrero‐de las Heras, Johannes Zuber, Marcus Buschbeck, Sonia‐V Forcales, Eva Martínez‐Balibrea   +14 more
wiley   +1 more source

Mutational Analysis of the Poly(ADP-Ribosyl)ation Sites of the Transcription Factor CTCF Provides an Insight into the Mechanism of Its Regulation by Poly(ADP-Ribosyl)ation [PDF]

, 2010
Poly(ADP-ribosyl)ation of the conserved multifunctional transcription factor CTCF was previously identified as important to maintain CTCF insulator and chromatin barrier functions.
Klenova, Elena, Rai, Sushma, Ito, Yoko, Chernukhin, Igor, Murrell, Adele, Jagodic, Maja, Farrar, Dawn, Ohlsson, Rolf, Yammine, Samer, Yammine, S,, Farrar, D, Ito, Y, Ohlsson, R,, Jagodic, M,, Rai, S, Murrell, A, Chernukhin, I, Klenova, E   +17 more
core   +1 more source

Translational Aspects of DNA Damage Repair in Optimizing Cancer Chemotherapy

Advanced Genetics, Volume 6, Issue 4, December 2025.
This review systematically delineates the fundamental role and recent advancements in DNA damage response (DDR) within the context of cancer chemotherapy. Particular emphasis is directed toward exploring the interplay between DDR status and chemosensitivity.
Anqi Lin, Jinyue He, Aimin Jiang, Jian Zhang, Quan Cheng, Hengguo Zhang, Wenjun Mao, Peng Luo   +7 more
wiley   +1 more source