Results 61 to 70 of about 3,094 (198)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, Volume 16, Issue 5, Page 1020-1029, May 2026.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells

Translational Oncology, 2022
The PARP-1 expression level and poly (ADP-ribosyl)ation activity in cancer markedly affect the therapeutic outcome. Nicaraven, a free radical scavenger has been found to inhibit PARP, but the effect on cancer cells is still unclear.
Lina Abdelghany, Tsuyoshi Kawabata, Shinji Goto, Keiichi Jingu, Tao-Sheng Li   +4 more
doaj   +1 more source

Pan‐Modification Proteoformics: A Framework for Decoding Proteomic Complexity in Health and Disease

Barrier Immunity, Volume 2, Issue 1, Page 32-49, March 2026.
Post‐translational modification (PTM) diversity represents a central regulatory layer that drives protein functional complexity. Classical PTMs (phosphorylation, acetylation, ubiquitination, and glycosylation) and emerging PTMs (SUMOylation, lipidation, and ADP‐ribosylation) form dynamic modification codes that govern signaling, metabolism, and ...
Yang Yang, Wenzhi Guo, Jing‐Hua Yang
wiley   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions [PDF]

Biochemical Journal, 1999
Poly(ADP-ribosyl)ation is a post-translational modification of proteins. During this process, molecules of ADP-ribose are added successively on to acceptor proteins to form branched polymers. This modification is transient but very extensive in vivo, as polymer chains can reach more than 200 units on protein acceptors.
D, D'Amours, S, Desnoyers, I, D'Silva, G G, Poirier   +3 more
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, Volume 600, Issue 4, Page 418-438, February 2026.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

ADP-ribose hydrolases: biological functions and potential therapeutic targets

Expert Reviews in Molecular Medicine
ADP-ribosylation (ADPRylation), which encompasses poly(ADP-ribosyl)ation and mono(ADP-ribosyl)ation, is an important post-translational modification catalysed by the poly(ADP-ribose) polymerase (PARP) enzyme superfamily.
Jingpeng Wang, Zhao-Qi Wang, Wen Zong
doaj   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

Biological Roles of Mono- and Poly (ADP-Ribosyl) ation

Journal of Nutritional Science and Vitaminology, 1992
Biological roles of mono- and poly (ADP-ribosyl) ation reactions are reviewed, along with analysis of functional sequences of poly(ADP-ribose) synthetase and inhibitors of the synthetase compared with mono (ADP-ribosyl) transferase.
UEDA, K., BANASIK, M., SAITO, L., KIDO, T., DAS, B. R., ABED, N. A. N., KOMURA, H.   +6 more
openaire   +3 more sources

CCNE1 Exerts a Protective Effect on Parkinson's Disease by Regulating Ferroptosis‐Related Proteins

Brain and Behavior, Volume 15, Issue 12, December 2025.
This study provides the first molecular insight into how CCNE1 exerts neuroprotective effects through the regulation of the ferroptosis key protein PARP16, offering a novel perspective for Parkinson's disease mechanism research. ABSTRACT Background The pathogenesis of Parkinson's disease (PD) is closely linked to ferroptosis, yet the mechanism by which
Jia Fu, Jing Zhao, Na Mi, Chao Zhang, Yali Zhang, Lifen Yao   +5 more
wiley   +1 more source