TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging
Journal of Medical Virology, Volume 97, Issue 11, November 2025.ABSTRACT Torquetenovirus (TTV) is a prevalent virus whose clinical significance remains unclear, potentially linked to immunosenescence. This study examines TTV species in relation to immune impairment, inflammation, and cellular stress response in aging.
Federica Novazzi +35 more
wiley +1 more source
Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis. [PDF]
Cell Cycle, 2014 Poly(ADP-ribosyl)ation is an unique posttranslational modification and required for spindle assembly and function during mitosis. However, the molecular mechanism of poly(ADP-ribose) (PAR) in mitosis remains elusive. Here, we show the evidence that PAR is recognized by ECT2, a key guanine nucleotide exchange factor in mitosis.
Li M, Bian C, Yu X.
europepmc +4 more sources
Cancer Medicine, Volume 14, Issue 17, September 2025.Emerging radiopharmaceuticals in nuclear medicine could improve ovarian cancer diagnosis and staging, while also enabling assessment of treatment response, therapy resistance, and suitability for targeted therapies. ABSTRACT Aims This review summarizes the role and future prospects of nuclear medicine in ovarian cancer, focusing on novel ...
Mara M. K. Veenstra +7 more
wiley +1 more source
Targeting dePARylation for cancer therapy
Cell & Bioscience, 2020 Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects ...
Muzaffer Ahmad Kassab +2 more
doaj +1 more source
Aging Cell, Volume 24, Issue 9, September 2025.Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini +14 more
wiley +1 more source
Correction to: PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR γ in cardiac fibroblast [PDF]
, 2021 openalex +1 more source
The Dichotomy of the Poly(ADP-Ribose) Polymerase-Like Thermozyme from Sulfolobus solfataricus
Challenges, 2018 The first evidence of an ADP-ribosylating activity in Archaea was obtained in Sulfolobus solfataricus(strain MT-4) where a poly(ADP-ribose) polymerase (PARP)-like thermoprotein, defined with the acronymous PARPSso, was found.
Maria Rosaria Faraone Mennella
doaj +1 more source
Mono(ADP-ribosyl)ation and Poly(ADP-ribosyl)ation of Proteins in Developing Liver and in Hepatomas. Relation of Conjugate Subfractions to Metabolic Competence and Proliferation Rates [PDF]
, 1981 Reinhard Bredehorst +4 more
openalex +1 more source
PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 (NRF2) affecting NRF2 subcellular localization [PDF]
, 2023 L Jankó +6 more
openalex +1 more source
PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment. [PDF]
Commun Biol, 2023 Maresca C +12 more
europepmc +1 more source