Results 81 to 90 of about 6,825 (206)

Mono-ADP-ribosylation, a MARylationmultifaced modification of protein, DNA and RNA: characterizations, functions and mechanisms

Cell Death Discovery
The functional alterations of proteins and nucleic acids mainly rely on their modifications. ADP-ribosylation is a NAD+-dependent modification of proteins and, in some cases, of nucleic acids.
Hao Wu, Anqi Lu, Jiuzhi Yuan, Yang Yu, Chongning Lv, Jincai Lu   +5 more
doaj   +1 more source

Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis. [PDF]

Cell Cycle, 2014
Poly(ADP-ribosyl)ation is an unique posttranslational modification and required for spindle assembly and function during mitosis. However, the molecular mechanism of poly(ADP-ribose) (PAR) in mitosis remains elusive. Here, we show the evidence that PAR is recognized by ECT2, a key guanine nucleotide exchange factor in mitosis.
Li M, Bian C, Yu X.
europepmc   +4 more sources

PARP Activity Is Essential for Retinal Photoreceptor Survival in the Human Homologous RhoI255del Mouse Model for Autosomal Dominant Retinitis Pigmentosa

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
Inhibition of PARP with different selective inhibitors (PARPi). Olaparib (Ola), Saruparib (Sar), INO1001 (INO), and nicotinamide (NAM) all increase photoreceptor cell death in the RhoI255del/+ mouse model for autosomal dominant retinitis pigmentosa.
Yu Zhu, Azdah Hamed A. Fallatah, Kangwei Jiao, Mathias W. Seeliger, François Paquet‐Durand   +4 more
wiley   +1 more source

Poly(ADP-ribose) polymerase 1 orchestrates vascular smooth muscle cell homeostasis in arterial disease

Experimental and Molecular Medicine
Smooth muscle cells are remarkably plastic. Their reversible differentiation is required for growth and wound healing but also contributes to pathologies such as atherosclerosis and restenosis.
Wenjing Xu, Yichen Wu, Ruiqi Mao, Yujie Jia, Hao Jiang, Fengxiao Zhang, Dan Huang, Ximiao He, Cheng Wang, Kai Huang   +9 more
doaj   +1 more source

The Ageing Process Affects the Antioxidant Defences and the Poly (ADPribosyl)ation Activity in Cistus Incanus L. Leaves

Antioxidants, 2019
The ageing process in living organisms is characterised by the accumulation of several deleterious changes occurring in cells and tissues. The increase of reactive oxygen species with the advancement of age is responsible for the oxidative damage to ...
Carmen Arena, Luca Vitale, Anna Rita Bianchi, Carmela Mistretta, Ermenegilda Vitale, Costantino Parisi, Giulia Guerriero, Vincenzo Magliulo, Anna De Maio   +8 more
doaj   +1 more source

Poly(ADP-ribose) polymerases regulate cell division and development in Arabidopsis roots [PDF]

, 2017
Root organogenesis involves cell division, differentiation and expansion. The molecular mechanisms regulating root development are not fully understood. In this study, we identified poly (ADP-ribose) polymerases (PARPs) as new players in root development.
Ge, Xiaochun, Gu, Zongyin, Liu, Caifeng, Liu, Weiwei, Ma, Hong, Wang, Wenjing, Wu, Qiao, Xu, Ping   +7 more
core   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, Volume 599, Issue 22, Page 3355-3368, November 2025.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Mammalian Spermatogenesis, DNA Repair, Poly(ADP-ribose) Turnover: the State of the Art [PDF]

, 2011
DNA repair and poly(ADP-ribosyl)ation system during spermatogenesis under physiological and pathological conditions
Faraone Mennella, Maria Rosaria
core   +1 more source

TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT Torquetenovirus (TTV) is a prevalent virus whose clinical significance remains unclear, potentially linked to immunosenescence. This study examines TTV species in relation to immune impairment, inflammation, and cellular stress response in aging.
Federica Novazzi, Pietro Giorgio Spezia, Francesca Drago Ferrante, Angelo Paolo Genoni, Paolo Antonio Grossi, Nicasio Mancini, Marco Malavolta, Marta Balietti, Francesco Piacenza, Serena Marcozzi, Carlo Fortunato, Gretta Veronica Badillo Pazmay, Laura Cianfruglia, Alexander Bürkle, María Moreno‐Villanueva, Martijn E. T. Dollé, Eugène Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Michele Zampieri, Paola Caiafa, Fabio Ciccarone, Anna Reale, Birgit Weinberger, Ewa Sikora, Florence Debacq‐Chainiaux, Wolfgang Stuetz, Mikko Hurme, P. Eline Slagboom, Jürgen Bernhardt, Fabiola Olivieri, Fabio Filippini, Fabrizio Maggi, Robertina Giacconi   +35 more
wiley   +1 more source

Poly(ADP-ribose) Polymerase-1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Potential [PDF]

, 2014
Poly(ADP-ribosyl)ation reactions, carried out by poly(ADP-ribose) polymerases (PARPs/ARTDs), are reversible posttranslational modifications impacting on numerous cellular processes (e.g., DNA repair, transcription, metabolism, or immune functions). PARP1
Bay, Péter, Little, P., Liu, P., Xu, S.
core   +1 more source