Results 81 to 90 of about 1,124 (169)

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development.

, 2004
BACKGROUND: Poly (ADP-ribosyl)ation is a covalent modification of many nuclear proteins. It has a strong chromatin modifying potential involved in DNA repair, transcription and replication. Its role during preimplantation development is unknown. RESULTS:
Thi NEILDEZ, Paldi, Andras, Andras PALDI, Catherine THENEVIN, Thenevin, Catherine, Imamura, Takuya, Takuya IMAMURA, Neildez, Thi My Anh   +7 more
core   +1 more source

Inhibition of poly (ADP-ribosyl)ation allows DNA hypermethylation

, 2005
This chapter emphasizes that along the chain of events that induce DNA methylation-dependent chromatin condensation, a post-synthetic modification other than histone acetylation, poly(ADP-ribosyl)ation, participates in the establishment and maintenance ...
REALE, Anna, M. MALANGA, J. ZLATANOVA, Caiafa, P, Zlatanova, J, Malanga, M, CAIAFA, Paola, Reale, A, ZARDO, GIUSEPPE, Zardo, G   +9 more
core  

Poly(ADP-Ribose) Polymerase (PARP) signaling of DNA damage induced by Topoisomerase 1 (TOP1) inhibition in carcinoma cells: chemotherapeutic implications of PARP and TOP1 inhibitors.

, 2010
Una nuova strategia molecolare che incrementa l’azione antitumorale degli inibitori della Topoisomerasi 1 (TOP1) si basa sull’utilizzo di inibitori delle poli(ADP-ribosio) polimerasi (PARP).
D'Onofrio, Giovanna
core  

The Dichotomy of the Poly(ADP-Ribose) Polymerase-Like Thermozyme from Sulfolobus solfataricus

Challenges, 2018
The first evidence of an ADP-ribosylating activity in Archaea was obtained in Sulfolobus solfataricus(strain MT-4) where a poly(ADP-ribose) polymerase (PARP)-like thermoprotein, defined with the acronymous PARPSso, was found.
Maria Rosaria Faraone Mennella
doaj   +1 more source

The expanding field of poly(ADP‐ribosyl)ation reactions

, 2008
Poly(ADP-ribosyl)ation is a post-translational modification of proteins that is mediated by poly(ADP-ribose) polymerases (PARPs). Although the existence and nature of the nucleic acid-like molecule poly(ADP-ribose) (PAR) has been known for 40 years ...
Dantzer, F. (Françoise), Antoinette Hakmé, Valérie Schreiber, Hakmé, A. (Antoinette), Françoise Dantzer, Schreiber, Valérie, Heng‐Kuan Wong, Dantzer, Françoise, Wong, Heng-Kuan, Schreiber, V. (Valerie), Hakmé, Antoinette, Wong, H. (Heng‐Kuan)   +11 more
core   +1 more source

The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin. A role of poly(ADP-ribosyl)ation on core nucleosome structure

, 1989
The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin was analyzed by gel electrophoresis, electron microscopy, and velocity sedimentation.
Lamarre, D, Muller, S, Poirier, G G, Ménard, L, Hengartner, M, Huletsky, A, Murcia, G,   +6 more
core  

Characterization and role of poly(ADP-ribosyl)ation in the Mediterranean species Cistus incanus L. under different temperature conditions.

, 2011
In plants, the decline of poly(ADP-ribosyl)ation activity is involved in energy homeostasis and stress tolerance. By reducing stress-induced poly(ADP-ribosyl)ation activity, NADþ breakdown is inhibited preventing high energy consumption.
MISTRETTA, CARMELA, E. Di Natale, Emiliana Di Natale, Maria Rosaria Faraone Mennella, Anna De Maio, ARENA, CARMEN, VIRZO, AMALIA, DE MAIO, ANNA, Amalia Virzo De Santo, FARAONE MENNELLA, MARIA ROSARIA, Carmen Arena, Carmela Mistretta   +11 more
core   +1 more source

Poly(ADP-ribosyl)ation Regulates Insulator Function and Intrachromosomal Interactions in Drosophila

, 2013
SummaryInsulators mediate inter- and intrachromosomal contacts to regulate enhancer-promoter interactions and establish chromosome domains. The mechanisms by which insulator activity can be regulated to orchestrate changes in the function and three ...
Ramos, Edward, Corces, Victor G., Van Bortle, Kevin, Ong, Chin-Tong   +3 more
core   +1 more source

New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage

BMC Plant Biology, 2019
Background Poly (ADP-ribosyl) ation (PARylation) is an important posttranslational modification that regulates DNA repair, gene transcription, stress responses and developmental processes in multicellular organisms.
Zongying Gu, Weiyang Pan, Wei Chen, Qichao Lian, Qiao Wu, Zeyu Lv, Xuan Cheng, Xiaochun Ge   +7 more
doaj   +1 more source