Results 81 to 90 of about 602,119 (146)

Inhibition of poly (ADP-ribosyl)ation allows DNA hypermethylation

, 2005
This chapter emphasizes that along the chain of events that induce DNA methylation-dependent chromatin condensation, a post-synthetic modification other than histone acetylation, poly(ADP-ribosyl)ation, participates in the establishment and maintenance ...
REALE, Anna, M. MALANGA, J. ZLATANOVA, Caiafa, P, Zlatanova, J, Malanga, M, CAIAFA, Paola, Reale, A, ZARDO, GIUSEPPE, Zardo, G   +9 more
core  

PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment. [PDF]

Commun Biol, 2023
Maresca C, Dello Stritto A, D'Angelo C, Petti E, Rizzo A, Vertecchi E, Berardinelli F, Bonanni L, Sgura A, Antoccia A, Graziani G, Biroccio A, Salvati E.   +12 more
europepmc   +1 more source

Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation

, 2004
Chromatin insulators demarcate expression domains by blocking the cis effects of enhancers or silencers in a position-dependent manner1, 2. We show that the chromatin insulator protein CTCF carries a post-translational modification: poly(ADP-ribosyl ...
Mukhopadhyay, Rituparna,, Andrew P Feinberg, Farrar, Dawn, Igor Chernukhin, Dawn Farrar, Pant, Vinod,, Chernukhin, Igor, Docquier, France, Tavoosidana, Gholamreza,, Elena Klenova, France Docquier, Lobanenkov, Victor, Kanduri, Chandrasekhar,, Wenqiang Yu, Vasudeva Ginjala, Rolf Ohlsson, Rolf Ohlsson, Rolf,, Mitsuo Oshimura, Joanne Whitehead, Whitehead, Joanne,, Oshimura, Mitsuo, Klenova, Elena, Rituparna Mukhopadhyay, Yu, Wenqiang,, Feinberg, Andrew P, Gholamreza Tavoosidana, Victor Lobanenkov, Vinod Pant, Chandrasekhar Kanduri, Ginjala, Vasudeva,   +29 more
core   +1 more source

Inhibition of GSDMD Activates Poly(ADP-ribosyl)ation and Promotes Myocardial Ischemia-Reperfusion Injury. [PDF]

Oxid Med Cell Longev, 2022
Zhang ZH, Zhang ZG, Chen MW, Yang Y, Li RJ, Xu JJ, Yang C, Li YY, Chen HW, Liu SX, Li YL, Luo P, Liu YJ, Chen WB, Shan ZG, Huang ZR.   +15 more
europepmc   +1 more source

Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage. [PDF]

Cell Commun Signal, 2022
Liu HY, Liu YY, Zhang YL, Ning Y, Zhang FL, Li DQ.   +5 more
europepmc   +1 more source

Physiology and pathophysiology of poly(ADP-ribosyl)ation

One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post-translational modification of nuclear proteins with poly(ADP-ribose) from NAD+ as precursor, mostly catalysed by poly(ADP-ribose) polymerase-1 (PARP-1).
Burkle A
core   +5 more sources

HDAC inhibitors suppress protein poly(ADP-ribosyl)ation and DNA repair protein levels and phosphorylation status in hematologic cancer cells: implications for their use in combination with PARP inhibitors and chemotherapeutic drugs. [PDF]

Oncotarget, 2022
Valdez BC, Nieto Y, Yuan B, Murray D, Andersson BS.   +4 more
europepmc   +1 more source

NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis

Cell Reports
Summary: We identified poly(ADP-ribose) polymerase 7 (PARP7), a mono(ADP-ribosyl) transferase, as a regulator of C/EBPβ-dependent proadipogenic gene expression.
MiKayla S. Stokes, Yoon Jung Kim, Yonghyeon Kim, Sneh Koul, Shu-Ping Chiu, Chenqian Liu, Morgan Dasovich, Josue Zuniga, Tulip Nandu, Dan Huang, Thomas P. Mathews, Ashley Solmonson, Cristel V. Camacho, W. Lee Kraus   +13 more
doaj   +1 more source

The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy. [PDF]

Acta Pharm Sin B, 2021
Li Z, Guo Z, Lan R, Cai S, Lin Z, Li J, Wang J, Li Z, Liu P.   +8 more
europepmc   +1 more source

The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context. [PDF]

Sci Rep, 2021
Kutuzov MM, Belousova EA, Kurgina TA, Ukraintsev AA, Vasil'eva IA, Khodyreva SN, Lavrik OI.   +6 more
europepmc   +1 more source