Results 51 to 60 of about 1,124 (169)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, Volume 600, Issue 4, Page 418-438, February 2026.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells

Translational Oncology, 2022
The PARP-1 expression level and poly (ADP-ribosyl)ation activity in cancer markedly affect the therapeutic outcome. Nicaraven, a free radical scavenger has been found to inhibit PARP, but the effect on cancer cells is still unclear.
Lina Abdelghany, Tsuyoshi Kawabata, Shinji Goto, Keiichi Jingu, Tao-Sheng Li   +4 more
doaj   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Redox Biology, 2021
Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients.
Juan Manuel Martí, Angel Garcia-Diaz, Daniel Delgado-Bellido, Francisco O'Valle, Ariannys González-Flores, Onintza Carlevaris, José Manuel Rodríguez-Vargas, Jean Christophe Amé, Françoise Dantzer, George L. King, Klaudia Dziedzic, Edurne Berra, E. de Álava, A.T. Amaral, Ester M. Hammond, F. Javier Oliver   +15 more
doaj   +1 more source

Biological Roles of Mono- and Poly (ADP-Ribosyl) ation

Journal of Nutritional Science and Vitaminology, 1992
Biological roles of mono- and poly (ADP-ribosyl) ation reactions are reviewed, along with analysis of functional sequences of poly(ADP-ribose) synthetase and inhibitors of the synthetase compared with mono (ADP-ribosyl) transferase.
UEDA, K., BANASIK, M., SAITO, L., KIDO, T., DAS, B. R., ABED, N. A. N., KOMURA, H.   +6 more
openaire   +3 more sources

Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation [PDF]

Cell Death & Differentiation, 2014
The transcription factor adenovirus E2 promoter-binding factor (E2F)-1 normally enhances cell-cycle progression, but it also induces apoptosis under certain conditions, including DNA damage and serum deprivation. Although DNA damage facilitates the phosphorylation and stabilization of E2F1 to trigger apoptosis, how serum starvation renders cells ...
A, Kumari, T, Iwasaki, S, Pyndiah, E K, Cassimere, C D, Palani, D, Sakamuro   +5 more
openaire   +2 more sources

Mutational Analysis of the Poly(ADP-Ribosyl)ation Sites of the Transcription Factor CTCF Provides an Insight into the Mechanism of Its Regulation by Poly(ADP-Ribosyl)ation

, 2010
Poly(ADP-ribosyl)ation of the conserved multifunctional transcription factor CTCF was previously identified as important to maintain CTCF insulator and chromatin barrier functions.
Klenova, Elena, Rai, Sushma, Ito, Yoko, Chernukhin, Igor, Murrell, Adele, Jagodic, Maja, Farrar, Dawn, Ohlsson, Rolf, Yammine, Samer   +8 more
core   +1 more source

CCNE1 Exerts a Protective Effect on Parkinson's Disease by Regulating Ferroptosis‐Related Proteins

Brain and Behavior, Volume 15, Issue 12, December 2025.
This study provides the first molecular insight into how CCNE1 exerts neuroprotective effects through the regulation of the ferroptosis key protein PARP16, offering a novel perspective for Parkinson's disease mechanism research. ABSTRACT Background The pathogenesis of Parkinson's disease (PD) is closely linked to ferroptosis, yet the mechanism by which
Jia Fu, Jing Zhao, Na Mi, Chao Zhang, Yali Zhang, Lifen Yao   +5 more
wiley   +1 more source

ADP-ribose hydrolases: biological functions and potential therapeutic targets

Expert Reviews in Molecular Medicine
ADP-ribosylation (ADPRylation), which encompasses poly(ADP-ribosyl)ation and mono(ADP-ribosyl)ation, is an important post-translational modification catalysed by the poly(ADP-ribose) polymerase (PARP) enzyme superfamily.
Jingpeng Wang, Zhao-Qi Wang, Wen Zong
doaj   +1 more source

Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation

, 2004
Chromatin insulators demarcate expression domains by blocking the cis effects of enhancers or silencers in a position-dependent manner1, 2. We show that the chromatin insulator protein CTCF carries a post-translational modification: poly(ADP-ribosyl ...
Mukhopadhyay, Rituparna,, Andrew P Feinberg, Farrar, Dawn, Igor Chernukhin, Dawn Farrar, Pant, Vinod,, Chernukhin, Igor, Docquier, France, Tavoosidana, Gholamreza,, Elena Klenova, France Docquier, Lobanenkov, Victor, Kanduri, Chandrasekhar,, Wenqiang Yu, Vasudeva Ginjala, Rolf Ohlsson, Rolf Ohlsson, Rolf,, Mitsuo Oshimura, Joanne Whitehead, Whitehead, Joanne,, Oshimura, Mitsuo, Klenova, Elena, Rituparna Mukhopadhyay, Yu, Wenqiang,, Feinberg, Andrew P, Gholamreza Tavoosidana, Victor Lobanenkov, Vinod Pant, Chandrasekhar Kanduri, Ginjala, Vasudeva,   +29 more
core   +1 more source