Results 31 to 40 of about 3,094 (198)
PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses. [PDF]
PLoS Genetics, 2015 Poly (ADP-ribose) polymerases (PARPs) catalyze the transfer of multiple poly(ADP-ribose) units onto target proteins. Poly(ADP-ribosyl)ation plays a crucial role in a variety of cellular processes including, most prominently, auto-activation of PARP at ...
Junqi Song +3 more
doaj +1 more source
Identification of poly(ADP-ribose) polymerase-1 as a cell cycle regulator through modulating Sp1 mediated transcription in human hepatoma cells. [PDF]
PLoS ONE, 2013 The transcription factor Sp1 is implicated in the activation of G0/G1 phase genes. Modulation of Sp1 transcription activities may affect G1-S checkpoint, resulting in changes in cell proliferation.
Liu Yang +13 more
doaj +1 more source
Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation [PDF]
Journal of Biological Chemistry, 2016 Ishibashi Toyotaka +2 more
exaly +2 more sources
Poly(ADP-ribosyl)ation in mammalian ageing [PDF]
Nucleic Acids Research, 2007 Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways.
Beneke, Sascha, Bürkle, Alexander
openaire +3 more sources
Cells, 2021 Mono(ADP-ribosyl)ation (MARylation) is a regulatory post-translational modification of proteins that controls their functions through a variety of mechanisms. MARylation is catalyzed by mono(ADP-ribosyl) transferase (MART) enzymes, a subclass of the poly(
Sridevi Challa +2 more
doaj +1 more source
Disordered Protein Tail Is Wagging Poly(ADP-ribosyl)ation. [PDF]
Int J Mol SciIntrinsically disordered regions (IDRs) are present in nearly all proteins, often accounting for more than 40% of their amino acid sequence. Unlike structured domains, IDRs lack sequence or structural conservation across species while maintaining conserved biological functions.
Bordet G +5 more
europepmc +3 more sources
JCI Insight, 2022 HDL cholesterol (HDL-C) predicts risk of cardiovascular disease (CVD), but the factors regulating HDL are incompletely understood. Emerging data link CVD risk to decreased HDL-C in 8% of the world population and 40% of East Asians who carry an SNP of ...
Luxiao Li +10 more
doaj +1 more source
Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes.
PLoS ONE, 2021 ADP-ribosylation is a key post-translational modification that regulates a wide variety of cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers.
Samuel Kasson +2 more
doaj +1 more source
ADP-Ribosylation and Antiviral Resistance in Plants
Viruses, 2023 ADP-ribosylation (ADPRylation) is a versatile posttranslational modification in eukaryotic cells which is involved in the regulation of a wide range of key biological processes, including DNA repair, cell signalling, programmed cell death, growth and ...
Nadezhda Spechenkova +4 more
doaj +1 more source
Human PARP1 substrates and regulators of its catalytic activity: An updated overview
Frontiers in Pharmacology, 2023 Poly (ADP-ribose) polymerase 1 (PARP1) is a key DNA damage sensor that is recruited to damaged sites after DNA strand breaks to initiate DNA repair. This is achieved by catalyzing attachment of ADP-ribose moieties, which are donated from NAD+, on the ...
Tao Zhu +5 more
doaj +1 more source