Results 31 to 40 of about 602,119 (146)
Human PARP1 substrates and regulators of its catalytic activity: An updated overview
Frontiers in Pharmacology, 2023 Poly (ADP-ribose) polymerase 1 (PARP1) is a key DNA damage sensor that is recruited to damaged sites after DNA strand breaks to initiate DNA repair. This is achieved by catalyzing attachment of ADP-ribose moieties, which are donated from NAD+, on the ...
Tao Zhu +5 more
doaj +1 more source
Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase. [PDF]
PLoS ONE, 2014 Protein poly(ADP-ribosyl)ation (PARylation) regulates a number of important cellular processes. Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for hydrolyzing the poly(ADP-ribose) (PAR) polymer in vivo.
Zhizhi Wang +3 more
doaj +1 more source
Cas9 is mostly orthogonal to human systems of DNA break sensing and repair.
PLoS ONE, 2023 CRISPR/Cas9 system is а powerful gene editing tool based on the RNA-guided cleavage of target DNA. The Cas9 activity can be modulated by proteins involved in DNA damage signalling and repair due to their interaction with double- and single-strand breaks (
Ekaterina A Maltseva +9 more
doaj +1 more source
Effect of zinc on cellular poly(ADP-ribosyl)ation capacity
, 2007 Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability.
Malavolta, Marco +5 more
core +2 more sources
Protein poly(ADP-ribosyl)ation regulates arabidopsis immune gene expression and defense responses. [PDF]
PLoS Genetics, 2015 Perception of microbe-associated molecular patterns (MAMPs) elicits transcriptional reprogramming in hosts and activates defense to pathogen attacks. The molecular mechanisms underlying plant pattern-triggered immunity remain elusive.
Baomin Feng +8 more
doaj +1 more source
Frontiers in Plant Science, 2018 Cell wall reinforcement with callose is a frequent plant response to infection. Poly(ADP-ribosyl)ation is a protein post-translational modification mediated by poly(ADP-ribose) polymerases (PARPs).
Brian D. Keppler +4 more
doaj +1 more source
, 2014 Poly(ADP-ribose) polymerase-2 (PARP-2) catalyzes poly(ADP-ribosyl)ation (PARylation) and regulates numerous nuclear processes, including transcription. Depletion of PARP-2 alters the activity of transcription factors and global gene expression.
Ya-Chen Liang +3 more
core +1 more source
陆军军医大学学报, 2023 Objective To investigate the role and molecular mechanism of poly (ADP-ribose) polymerase 1 (PARP1) in mitosis of HeLa cells. Methods Flow cytometry, immunofluorescent assay and live cell imaging were used to detect the effect of PARP1 on mitosis of HeLa
YANG Xue +5 more
doaj +1 more source
Synergistic cytotoxicity of fludarabine, clofarabine, busulfan, vorinostat and olaparib in AML cells
Frontiers in Oncology, 2023 Combinations of nucleoside analog(s) and DNA alkylating agent(s) are used for cancer treatment as components of pre-transplant regimens used in hematopoietic stem cell transplantation.
Benigno C. Valdez +7 more
doaj +1 more source
Poly(ADP-ribosyl)ation, genomic instability, and longevity
Poly(ADP-ribosyl)ation is a DNA strandbreak-driven posttranslational modification of nuclear proteins that is catalyzed by poly(ADP-ribose) polymerase-l (PARP-1), with NAD+ serving as substrate. Recently, additional PARP isoforms were described that seem
Burkle A
core +5 more sources