Results 21 to 30 of about 602,119 (146)

Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation [PDF]

Journal of Biological Chemistry, 2016
Ishibashi Toyotaka, Michele Rouleau, Guy Poirier   +2 more
exaly   +2 more sources

Poly(ADP-ribosyl)ation and aging

Poly(ADP-ribosyl)ation is a DNA strand break-driven post-translational modification of proteins catalyzed by poly (ADP-ribose) polymerase-1 (PARP-1). with NAD+ serving as substrate.
Burkle A, Muiras ML, Beneke S
core   +5 more sources

Molecular Characterization of a Novel Intracellular ADP-Ribosyl Cyclase [PDF]

, 2007
Background. ADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Jonathan S Marchant, Marchant, JS, Michael J Boulware, Dev Churamani, Churamani, D, Dale, L, Geach Timothy J., Martin Andrew C.R., Gary W Moy, Andrew C R Martin, Sandip Patel, Dale Leslie, Yi-Hsien Su, Vacquier, VD, Vacquier Victor D., Su, YH, Patel Sandip, Churamani Dev, Boulware, MJ, Marchant Jonathan S., Leslie Dale, Boulware Michael J., Moy Gary W., Patel, S, Geach, TJ, Su Yi-Hsien, Moy, GW, Timothy J Geach, Martin, ACR, Victor D Vacquier   +29 more
core   +1 more source

Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles. [PDF]

PLoS ONE, 2012
Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcription and activity of Dnmt1.
Fabio Ciccarone, Francesca Gioia Klinger, Angela Catizone, Roberta Calabrese, Michele Zampieri, Maria Giulia Bacalini, Massimo De Felici, Paola Caiafa   +7 more
doaj   +1 more source

Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytes

Immunity & Ageing, 2006
Background Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalysed by poly(ADP-ribose) polymerases (PARPs), using NAD+ as a substrate.
Hyland Paul, Thaa Bastian, Malaisé Muriel, Annett Kathryn, Liu Dan, Kunzmann Andrea, Barnett Yvonne, Bürkle Alexander   +7 more
doaj   +1 more source

Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation. [PDF]

PLoS ONE, 2012
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which is followed by isolation of specific protein-DNA complexes and subsequent PCR testing, to analyze DNA-protein interactions.
Sascha Beneke, Kirstin Meyer, Anja Holtz, Katharina Hüttner, Alexander Bürkle   +4 more
doaj   +1 more source

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression

JCI Insight, 2022
HDL cholesterol (HDL-C) predicts risk of cardiovascular disease (CVD), but the factors regulating HDL are incompletely understood. Emerging data link CVD risk to decreased HDL-C in 8% of the world population and 40% of East Asians who carry an SNP of ...
Luxiao Li, Shanshan Zhong, Rui Li, Ningning Liang, Lili Zhang, Shen Xia, Xiaodong Xu, Xin Chen, Shiting Chen, Yongzhen Tao, Huiyong Yin   +10 more
doaj   +1 more source

Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes.

PLoS ONE, 2021
ADP-ribosylation is a key post-translational modification that regulates a wide variety of cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers.
Samuel Kasson, Nuwani Dharmapriya, In-Kwon Kim   +2 more
doaj   +1 more source

The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2014
Poly(ADP-ribose) polymerase-1 (PARP1) catalyzes the poly(ADP-ribosyl)ation of protein acceptors using NAD+ as the substrate is now considered as an important target for development of anticancer therapy. PARP1 is known to be post-translationally modified
Lianhua Piao, Daechun Kang, Takehiro Suzuki, Akiko Masuda, Naoshi Dohmae, Yusuke Nakamura, Ryuji Hamamoto   +6 more
doaj   +1 more source

ADP-Ribosylation and Antiviral Resistance in Plants

Viruses, 2023
ADP-ribosylation (ADPRylation) is a versatile posttranslational modification in eukaryotic cells which is involved in the regulation of a wide range of key biological processes, including DNA repair, cell signalling, programmed cell death, growth and ...
Nadezhda Spechenkova, Natalya O. Kalinina, Sergey K. Zavriev, Andrew J. Love, Michael Taliansky   +4 more
doaj   +1 more source