Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes.
PLoS ONE, 2021 ADP-ribosylation is a key post-translational modification that regulates a wide variety of cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers.
Samuel Kasson +2 more
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Journal of Translational Medicine, 2022 Background We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism.
Jeffrey Wang +6 more
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ADP-Ribosylation and Antiviral Resistance in Plants
Viruses, 2023 ADP-ribosylation (ADPRylation) is a versatile posttranslational modification in eukaryotic cells which is involved in the regulation of a wide range of key biological processes, including DNA repair, cell signalling, programmed cell death, growth and ...
Nadezhda Spechenkova +4 more
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Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase. [PDF]
PLoS ONE, 2014 Protein poly(ADP-ribosyl)ation (PARylation) regulates a number of important cellular processes. Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for hydrolyzing the poly(ADP-ribose) (PAR) polymer in vivo.
Zhizhi Wang +3 more
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Human PARP1 substrates and regulators of its catalytic activity: An updated overview
Frontiers in Pharmacology, 2023 Poly (ADP-ribose) polymerase 1 (PARP1) is a key DNA damage sensor that is recruited to damaged sites after DNA strand breaks to initiate DNA repair. This is achieved by catalyzing attachment of ADP-ribose moieties, which are donated from NAD+, on the ...
Tao Zhu +5 more
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A transcriptomics approach uncovers novel roles for poly(ADP-ribosyl)ation in the basal defense response in Arabidopsis thaliana. [PDF]
PLoS ONE, 2017 Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) or loss of Arabidopsis thaliana PARG1 (poly(ADP-ribose) glycohydrolase) disrupt a subset of plant defenses.
Amy G Briggs +7 more
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Regulation of mitosis by poly(ADP-ribosyl)ation [PDF]
Biochemical Journal, 2005 The spindle is a dynamic, microtubule-based structure responsible for chromosome segregation during cell division. Spindles in mammalian cells contain several thousand microtubules that are arranged into highly symmetric bipolar arrays by the actions of numerous microtubule-associated motor and non-motor proteins.
openaire +2 more sources
Molecular mechanism of poly(ADP-ribosyl)ation catalyzed by human poly(ADP-ribose) polymerase-1 [PDF]
, 2017 Human poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme which catalyzes protein poly(ADP-ribosyl)ation upon binding to DNA. NAD+ is used as a co-substrate in the reaction via iterative transfer of its ADP-ribose moiety to acceptor ...
Lin, Ke-Yi
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Cas9 is mostly orthogonal to human systems of DNA break sensing and repair.
PLoS ONE, 2023 CRISPR/Cas9 system is а powerful gene editing tool based on the RNA-guided cleavage of target DNA. The Cas9 activity can be modulated by proteins involved in DNA damage signalling and repair due to their interaction with double- and single-strand breaks (
Ekaterina A Maltseva +9 more
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Protein poly(ADP-ribosyl)ation regulates arabidopsis immune gene expression and defense responses. [PDF]
PLoS Genetics, 2015 Perception of microbe-associated molecular patterns (MAMPs) elicits transcriptional reprogramming in hosts and activates defense to pathogen attacks. The molecular mechanisms underlying plant pattern-triggered immunity remain elusive.
Baomin Feng +8 more
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