Regulation of chromatin structure by poly(ADP-ribosyl)ation [PDF]
Frontiers in Genetics, 2012 The interaction of DNA with proteins in the context of chromatin has to be tightly regulated to achieve so different tasks as packaging, transcription, replication and repair.
Sascha eBeneke
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Poly(ADP-Ribosyl)ation Affects Histone Acetylation and Transcription. [PDF]
PLoS ONE, 2015 Poly(ADP-ribosyl)ation (PARylation) is a posttranslational protein modification catalyzed by members of the poly(ADP-ribose) polymerase (PARP) enzyme family.
Loredana Verdone +5 more
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Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage. [PDF]
Cell Commun Signal, 2022 Liu HY +5 more
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A transcriptomics approach uncovers novel roles for poly(ADP-ribosyl)ation in the basal defense response in Arabidopsis thaliana. [PDF]
PLoS ONE, 2017 Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) or loss of Arabidopsis thaliana PARG1 (poly(ADP-ribose) glycohydrolase) disrupt a subset of plant defenses.
Amy G Briggs +7 more
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Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection [PDF]
Cell ReportsSummary: Poly(ADP-ribosyl)ation (PARylation), catalyzed mainly by poly(ADP-ribose) polymerase (PARP)1, is a key posttranslational modification involved in DNA replication and repair.
Julie Rageul +5 more
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PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease
MedCommThe poly(ADP‐ribose) polymerase (PARP) family consists of 17 members of nicotinamide adenine dinucleotide (NAD⁺)‐dependent enzymes that regulate key biological processes by catalyzing adenosine diphosphate (ADP)‐ribosylation, either poly(ADP‐ribosyl ...
Pengyuan Lei +9 more
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Changes in poly(ADP-ribosyl)ation patterns in workers exposed to BTX. [PDF]
PLoS ONE, 2014 Occupational exposure to (benzene, toluene and xylene, BTX is common in the Chinese workplace. Chronic occupational exposure to benzene is associated with an increased risk of hematological malignancies such as acute myeloid leukemia (AML), but the ...
Yan Sha +7 more
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RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair [PDF]
Cell Reports, 2018 Summary: The Fanconi anemia (FA) pathway is a pivotal genome maintenance network that orchestrates the repair of DNA interstrand crosslinks (ICLs). The tumor suppressors RUNX1 and RUNX3 were shown to regulate the FA pathway independent of their canonical
Lavina Sierra Tay +8 more
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Regulation of mitosis by poly(ADP-ribosyl)ation [PDF]
Biochemical Journal, 2005 The spindle is a dynamic, microtubule-based structure responsible for chromosome segregation during cell division. Spindles in mammalian cells contain several thousand microtubules that are arranged into highly symmetric bipolar arrays by the actions of numerous microtubule-associated motor and non-motor proteins.
Duane A. Compton
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Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination [PDF]
Molecular Plant, 2021 Andrew Bent, Zunyong Liu, Junqi Song
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