Results 11 to 20 of about 6,825 (206)

Poly(ADP-ribosyl)ation in mammalian ageing [PDF]

Science of Aging Knowledge Environment, 2007
Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision ...
Beneke, Sascha, Bürkle, Alexander
core   +9 more sources

Regulation of chromatin structure by poly(ADP-ribosyl)ation [PDF]

Frontiers in Genetics, 2012
The interaction of DNA with proteins in the context of chromatin has to be tightly regulated to achieve so different tasks as packaging, transcription, replication and repair.
Sascha eBeneke
doaj   +6 more sources

Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection [PDF]

Cell Reports
Summary: Poly(ADP-ribosyl)ation (PARylation), catalyzed mainly by poly(ADP-ribose) polymerase (PARP)1, is a key posttranslational modification involved in DNA replication and repair.
Julie Rageul, Natalie Lo, Amy L. Phi, Jinal A. Patel, Jennifer J. Park, Hyungjin Kim   +5 more
doaj   +2 more sources

PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease

MedComm
The poly(ADP‐ribose) polymerase (PARP) family consists of 17 members of nicotinamide adenine dinucleotide (NAD⁺)‐dependent enzymes that regulate key biological processes by catalyzing adenosine diphosphate (ADP)‐ribosylation, either poly(ADP‐ribosyl ...
Pengyuan Lei, Wenfeng Li, Jinhua Luo, Nanxin Xu, Yahe Wang, Dafei Xie, Hua Guan, Bo Huang, Xin Huang, Pingkun Zhou   +9 more
doaj   +2 more sources

Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination [PDF]

Molecular Plant, 2021
Ping He, Andrew F Bent, Junqi Song
exaly   +2 more sources

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins [PDF]

Nucleic Acids Research, 2019
Elizaveta E Alemasova, Olga I Lavrik
exaly   +2 more sources

PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells

Scientific Reports, 2022
In breast cancer, Poly(ADP-ribose) polymerase 3 (PARP3) has been identified as a key driver of tumor aggressiveness exemplifying its selective inhibition as a promising surrogate for clinical activity onto difficult-to-treat cancers. Here we explored the
Leonel Nguekeu-Zebaze, Najat Hanini, Aurélia Noll, Nadège Wadier, Jean-Christophe Amé, Lisa Roegel, Françoise Dantzer   +6 more
doaj   +1 more source

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme [PDF]

, 2015
5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation drives DNA demethylation events and is involved in the control of gene expression ...
CAIAFA, Paola, CICCARONE, FABIO, VALENTINI, ELISABETTA, ZAMPIERI, Michele   +3 more
core   +12 more sources

PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins

Frontiers in Cell and Developmental Biology, 2021
Poly(ADP-ribose) polymerase 1 (PARP1) is established as a key regulator of the cellular DNA damage response and apoptosis. In addition, PARP1 participates in the global regulation of DNA repair, transcription, telomere maintenance, and inflammation ...
Nikita V. Savelyev, Nikita V. Savelyev, Nikita M. Shepelev, Olga I. Lavrik, Olga I. Lavrik, Maria P. Rubtsova, Maria P. Rubtsova, Olga A. Dontsova, Olga A. Dontsova, Olga A. Dontsova, Olga A. Dontsova   +10 more
doaj   +1 more source

Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation [PDF]

Journal of Biological Chemistry, 2016
Michele Rouleau, Toyotaka Ishibashi, Juan Ausió   +2 more
exaly   +2 more sources