Poly(ADP-ribosyl)ation of p53 In Vitro and In Vivo Modulates Binding to its DNA Consensus Sequence [PDF]
Neoplasia: An International Journal for Oncology Research, 2001 The tumor-suppresser p53 undergoes extensive poly(ADP-ribosyl)ation early during apoptosis in human osteosarcoma cells, and degradation of poly(ADP-ribose) (PAR) attached to p53 coincides with poly(ADP-ribose)polymerase-1, (PARP-1) cleavage, and ...
Cynthia M. Simbulan-Rosenthal +7 more
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Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination [PDF]
Molecular Plant, 2021 Andrew Bent, Zunyong Liu, Junqi Song
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Tankyrase Regulates Neurite Outgrowth through Poly(ADP-ribosyl)ation-Dependent Activation of β-Catenin Signaling [PDF]
International Journal of Molecular Sciences, 2022 Hiroyuki Nakamura +2 more
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Disruption of Poly(ADP-ribosyl)ation Improves Plant Tolerance to Methyl Viologen-Mediated Oxidative Stress via Induction of ROS Scavenging Enzymes [PDF]
International Journal of Molecular SciencesViktoriya Samarskaya +2 more
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Scientific Reports, 2022 In breast cancer, Poly(ADP-ribose) polymerase 3 (PARP3) has been identified as a key driver of tumor aggressiveness exemplifying its selective inhibition as a promising surrogate for clinical activity onto difficult-to-treat cancers. Here we explored the
Leonel Nguekeu-Zebaze +6 more
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Frontiers in Cell and Developmental Biology, 2021 Poly(ADP-ribose) polymerase 1 (PARP1) is established as a key regulator of the cellular DNA damage response and apoptosis. In addition, PARP1 participates in the global regulation of DNA repair, transcription, telomere maintenance, and inflammation ...
Nikita V. Savelyev +10 more
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PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses. [PDF]
PLoS Genetics, 2015 Poly (ADP-ribose) polymerases (PARPs) catalyze the transfer of multiple poly(ADP-ribose) units onto target proteins. Poly(ADP-ribosyl)ation plays a crucial role in a variety of cellular processes including, most prominently, auto-activation of PARP at ...
Junqi Song +3 more
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Poly(ADP-ribosyl)ation, genomic instability, and longevity
, 2000 Poly(ADP-ribosyl)ation is a DNA strandbreak-driven posttranslational modification of nuclear proteins that is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1), with NAD(+) serving as substrate.
Burkle A
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Identification of poly(ADP-ribose) polymerase-1 as a cell cycle regulator through modulating Sp1 mediated transcription in human hepatoma cells. [PDF]
PLoS ONE, 2013 The transcription factor Sp1 is implicated in the activation of G0/G1 phase genes. Modulation of Sp1 transcription activities may affect G1-S checkpoint, resulting in changes in cell proliferation.
Liu Yang +13 more
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Cells, 2021 Mono(ADP-ribosyl)ation (MARylation) is a regulatory post-translational modification of proteins that controls their functions through a variety of mechanisms. MARylation is catalyzed by mono(ADP-ribosyl) transferase (MART) enzymes, a subclass of the poly(
Sridevi Challa +2 more
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