Results 41 to 50 of about 3,094 (198)
Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase. [PDF]
PLoS ONE, 2014 Protein poly(ADP-ribosyl)ation (PARylation) regulates a number of important cellular processes. Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for hydrolyzing the poly(ADP-ribose) (PAR) polymer in vivo.
Zhizhi Wang +3 more
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Cas9 is mostly orthogonal to human systems of DNA break sensing and repair.
PLoS ONE, 2023 CRISPR/Cas9 system is а powerful gene editing tool based on the RNA-guided cleavage of target DNA. The Cas9 activity can be modulated by proteins involved in DNA damage signalling and repair due to their interaction with double- and single-strand breaks (
Ekaterina A Maltseva +9 more
doaj +1 more source
New readers and interpretations of poly(ADP-ribosyl)ation [PDF]
Trends in Biochemical Sciences, 2012 Poly(ADP-ribosyl)ation (PARylation), a protein post-translational modification that was originally connected to the DNA damage response, is now known to engage in a continuously increasing number of biological processes. Despite extensive research and ceaseless, important findings about its role and mode of action, poly(ADP-ribose) remains an enigma ...
Kalisch, Thomas +3 more
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Effect of zinc on cellular poly(ADP-ribosyl)ation capacity [PDF]
Experimental Gerontology, 2007 Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process.
Andrea Kunzmann +5 more
openalex +5 more sources
Frontiers in Plant Science, 2018 Cell wall reinforcement with callose is a frequent plant response to infection. Poly(ADP-ribosyl)ation is a protein post-translational modification mediated by poly(ADP-ribose) polymerases (PARPs).
Brian D. Keppler +4 more
doaj +1 more source
In vitro poly(ADP-ribosyl)ation of seminal ribonuclease.
Journal of Biological Chemistry, 1986 The site of in vitro ADP-ribosylation of seminal ribonuclease was determined. Seminal enzyme was found to be a good receptor of [14C]ADP-ribose residues under the reaction conditions used. The recovery of [14C]ADP-ribosylated RNase was about 65% after purification.
H. SUZUKI +3 more
openaire +4 more sources
陆军军医大学学报, 2023 Objective To investigate the role and molecular mechanism of poly (ADP-ribose) polymerase 1 (PARP1) in mitosis of HeLa cells. Methods Flow cytometry, immunofluorescent assay and live cell imaging were used to detect the effect of PARP1 on mitosis of HeLa
YANG Xue +5 more
doaj +1 more source
Synergistic cytotoxicity of fludarabine, clofarabine, busulfan, vorinostat and olaparib in AML cells
Frontiers in Oncology, 2023 Combinations of nucleoside analog(s) and DNA alkylating agent(s) are used for cancer treatment as components of pre-transplant regimens used in hematopoietic stem cell transplantation.
Benigno C. Valdez +7 more
doaj +1 more source
Molecular Insights into Poly(ADP-ribose) Recognition and Processing
Biomolecules, 2012 Poly(ADP-ribosyl)ation is a post-translational protein modification involved in the regulation of important cellular functions including DNA repair, transcription, mitosis and apoptosis.
Ivan Ahel +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Y-box-binding protein 1 (YB-1) is a multifunctional protein involved in the regulation of gene expression. Recent studies showed that in addition to its role in the RNA and DNA metabolism, YB-1 is involved in the regulation of PARP1 activity, which ...
Konstantin N. Naumenko +10 more
doaj +1 more source