Results 41 to 50 of about 1,124 (169)

Rapamycin inhibits poly(ADP-ribosyl)ation in intact cells [PDF]

Biochemical and Biophysical Research Communications, 2009
Rapamycin is an immunosuppressive drug, which inhibits the mammalian target of rapamycin (mTOR) kinase activity inducing changes in cell proliferation. Synthesis of poly(ADP-ribose) (PAR) is an immediate cellular response to genotoxic stress catalyzed mostly by poly(ADP-ribose) polymerase 1 (PARP-1), which is also controlled by signaling pathways ...
Fahrer, Jörg, Wagner, Silvia, Königsrainer, Alfred, Bürkle, Alexander   +3 more
openaire   +3 more sources

Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source

Parp3 assists muscle function and skeletal muscle differentiation by selectively adjusting H3K27me3 enrichment

iScience
Summary: Poly(ADP-ribose) polymerase 3 (Parp3) is known for its role in DNA repair, mitotic division, and cancer aggressiveness. Still, its physiological roles have yet to be defined.
Zuleyha Yildirim, Aurélia Noll, Kathline Martin-Hernandez, Jean-Christophe Amé, Najat Hanini, Nadia Messaddeq, Isabelle Robert, Bernardo Reina San Martin, Gunn Hildrestrand, Magnar Bjoras, Françoise Dantzer   +10 more
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, Volume 16, Issue 5, Page 1020-1029, May 2026.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Inhibition of poly(ADP-Ribosyl)ation reduced vascular smooth muscle cells loss and improves aortic disease in a mouse model of human accelerated aging syndrome

Cell Death and Disease
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder associated with features of accelerated aging. HGPS is an autosomal dominant disease caused by a de novo mutation of LMNA gene, encoding A-type lamins, resulting in the ...
Déborah Cardoso, Solenn Guilbert, Philippe Guigue, Aurélie Carabalona, Karim Harhouri, Cécile Peccate, Johana Tournois, Zoheir Guesmia, Lino Ferreira, Catherine Bartoli, Nicolas Levy, Laurence Colleaux, Xavier Nissan, Antoine Muchir   +13 more
doaj   +1 more source

Pan‐Modification Proteoformics: A Framework for Decoding Proteomic Complexity in Health and Disease

Barrier Immunity, Volume 2, Issue 1, Page 32-49, March 2026.
Post‐translational modification (PTM) diversity represents a central regulatory layer that drives protein functional complexity. Classical PTMs (phosphorylation, acetylation, ubiquitination, and glycosylation) and emerging PTMs (SUMOylation, lipidation, and ADP‐ribosylation) form dynamic modification codes that govern signaling, metabolism, and ...
Yang Yang, Wenzhi Guo, Jing‐Hua Yang
wiley   +1 more source

Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling

Nature Communications
ADP-ribosylation has long been recognised as a key regulator of essential signalling pathways, including the DNA damage response. However, only recent and ongoing technological advances are beginning to make it possible to investigate its distinct forms ...
Helen Dauben, Mihaela Mihaljević, Andreas Kolvenbach, Maria Dilia Palumbieri, Chrysi Kapsali, Ina Huppertz, Ivan Matić   +6 more
doaj   +1 more source

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions [PDF]

Biochemical Journal, 1999
Poly(ADP-ribosyl)ation is a post-translational modification of proteins. During this process, molecules of ADP-ribose are added successively on to acceptor proteins to form branched polymers. This modification is transient but very extensive in vivo, as polymer chains can reach more than 200 units on protein acceptors.
D, D'Amours, S, Desnoyers, I, D'Silva, G G, Poirier   +3 more
openaire   +2 more sources

Does poly(ADP-ribosyl)ation regulate the DNA methylation pattern?

, 1997
The existence of a possible correlation between poly(ADP-ribosyl)ation and DNA methylation processes was investigated. In vivo and in vitro experiments were carried out on L929 mouse fibroblasts preincubated for 24 h with or without 3-aminobenzamide, a ...
REALE, Anna, STROM, Roberto, CAIAFA, Paola, PERILLI M., D'ERME, Maria, PERILLI M, ZARDO, GIUSEPPE   +6 more
core   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source