Results 161 to 170 of about 6,764 (212)
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Poly(ADP-ribosyl)ation and aging
Experimental Gerontology, 2004Poly(ADP-ribosyl)ation is a DNA strand break-driven post-translational modification of proteins catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1), with NAD+ serving as substrate. Poly(ADP-ribosyl)ation is triggered by DNA strand breaks, is functionally associated with DNA repair pathways and is a survival factor for cells under low to moderate levels
Alexander, Bürkle +2 more
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Poly(ADP-ribosyl)ation in carcinogenesis
Molecular Aspects of Medicine, 2013Cancer develops through diverse genetic, epigenetic and other changes, so-called 'multi-step carcinogenesis', and each cancer harbors different alterations and properties. Here in this article we review how poly(ADP-ribosyl)ation is involved in multi-step and diverse pathways of carcinogenesis.
Mitsuko, Masutani, Hiroaki, Fujimori
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Poly(ADP-ribosyl)ation studies in situ
Analytical Biochemistry, 1986We have studied the poly(ADP-ribosyl)ation of nuclear proteins in situ by examining the incorporation of [3H]NAD-derived ADP-ribose into polymers. We have devised a way to deliver [3H]NAD to cells growing in vitro, and we have determined the kinetics of uptake and incorporation into nuclear proteins using this delivery system.
D M, Duhl, L S, Hnilica
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50Years of poly(ADP-ribosyl)ation
Molecular Aspects of Medicine, 2013The seminal paper published in 1963 by Chambon, Weil and Mandel reporting a new NAD-dependent protein modification now known as poly(ADP-ribosyl)ation (PARylation) marked the launch of a new era in both protein research and cell biology. In the coming decades, the identity, biochemical characteristics and regulation of enzymes responsible for the ...
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Poly(ADP-ribosyl)ation and stroke
Pharmacological Research, 2005Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity affords substantial neuroprotection ...
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Role of poly(ADP-ribosyl)ation during human spermatogenesis
Fertility and Sterility, 2006Genomic stability of cells is known to be linked to their poly(ADP-ribosyl)ation capacity. We aimed to demonstrate, for the first time, the patterns of poly(ADP-ribosyl)ation during human spermatogenesis.Retrospective case-control study.Teaching hospital.Azoospermic men who underwent testicular biopsy for sperm recovery.Testicular biopsy evaluation by ...
Batia Bar-Shira, Maymon +8 more
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Inhibition of Poly(ADP-Ribosyl)ation Allows DNA Hypermethylation
2007This chapter emphasizes that along the chain of events that induce DNA methylation-dependent chromatin condensation, a post-synthetic modification other than histone acetylation, poly(ADP-ribosyl)ation, participates in the establishment and maintenance of methylation-free regions of chromatin.
REALE, Anna +4 more
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Physiology and pathophysiology of poly(ADP‐ribosyl)ation *
BioEssays, 2001AbstractOne of the immediate eukaryotic cellular responses to DNA breakage is the covalent post‐translational modification of nuclear proteins with poly(ADP‐ribose) from NAD+ as precursor, mostly catalysed by poly(ADP‐ribose) polymerase‐1 (PARP‐1). Recently several other polypeptides have been shown to catalyse poly(ADP‐ribose) formation.
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Chromosomal protein poly(ADP-ribosyl)ation in pancreatic nucleosomes
Canadian Journal of Biochemistry, 1982When pancreatic chromatin fragments were prepared and resolved in the presence of 80 mM NaCl, endogenous poly(ADP-ribose) polymerase activity was found to be maximal in nucleosome periodicities of four to five units and did not respond to any further increases in nucleosomal architecture.
R J, Aubin +4 more
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Poly(ADP‐Ribosyl)ation, Genomic Instability, and Longevity
Annals of the New York Academy of Sciences, 2000Abstract: Poly(ADP‐ribosyl)ation is a DNA strandbreak‐driven posttranslational modification of nuclear proteins that is catalyzed by poly(ADP‐ribose) polymerase‐1 (PARP‐1), with NAD+ serving as substrate. Recently, additional PARP isoforms were described that seem to account for a minor fraction of cellular poly(ADP‐ribose) synthesis.
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