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[45] Overview of poly(ADP-ribosyl)ation
1984Publisher Summary This chapter provides an overview of poly(ADP-ribosyl)ation. The formation of poly(ADP-ribose) by chromatin enzymes is actually initiated by ADP-ribosylation on chromatin proteins. The ADP-ribosylation reaction is catalyzed by enzymes which transfer the ADP-ribose residue of NAD + to various acceptor proteins.
Mark E. Smulson, Takashi Sugimura
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Does Poly(ADP-ribosyl)ation Regulate the DNA Methylation Pattern?
Biochemistry, 1997The existence of a possible correlation between poly(ADP-ribosyl)ation and DNA methylation processes was investigated. In vivo and in vitro experiments were carried out on L929 mouse fibroblasts preincubated for 24 h with or without 3-aminobenzamide, a well-known inhibitor of poly(ADP-ribose) polymerase.
ZARDO, GIUSEPPE +5 more
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Genomic Maintenance: The p53 Poly(ADP-ribosyl)ation Connection
Science's STKE, 2007The integrity of the genome in higher eukaryotes, as well as the modulation of its complex structure and functions, is exquisitely regulated. This genomic regulation occurs as a function of time in a very sophisticated and elaborate biological process called cell cycle progression, resulting in cell division, and is also controlled by a highly ...
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The role of poly(ADP-ribosyl)ation in epigenetic events
The International Journal of Biochemistry & Cell Biology, 2009Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone modifications, remodeling of nucleosomes and higher order chromatin modifications. In the framework of chromatin remodeling activities, the poly(ADP-ribosyl)ation of nuclear proteins catalyzed by PARPs, particularly PARP-1 and PARP-2, plays a ...
Quénet, Delphine +3 more
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Poly(ADP-ribosyl)ation, Genetic Instability, and Aging
1992Poly(ADP-ribosyl)ation is a posttranslational protein modification catalyzed by poly(ADP-ribose) polymerase (PARP), a highly conserved nuclear enzyme which uses nicotinamide-adenine dinucleotide (NAD) as substrate (for review, see [1]). The DNA-binding domain of the enzyme specifically binds to DNA single-or double-strand breaks, resulting in enzyme ...
A. Bürkle, K. Grube, J.-H. Küpper
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Poly(ADP-ribosyl)ation, DNA strand breaks, chromatin and cancer
Toxicology Letters, 1993Studies on poly(ADP-ribosyl)ation related to chromatin structure and to nuclear functions such as repair, gene expression and replication are reviewed. Poly(ADP-ribosyl)ation might be involved in regulating the activity of nuclear enzymes involved in the metabolism of DNA strand breaks such as ligase II and topoisomerases I and II.
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Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression
Nature Reviews Molecular Cell Biology, 2021Lori Anne Passmore, Jeff Coller
exaly
The role of poly(ADP-ribosyl)ation
1997S L, Oei, J, Griesenbeck, M, Schweiger
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Poly(ADP-ribose) polymerase inhibition: past, present and future
Nature Reviews Drug Discovery, 2020Nicola J Curtin, Csaba Szabo
exaly