Small StructuresBacterial keratitis induced by multidrug‐resistant (MDR) bacteria is a formidable challenge, posing a significant threat to public vision. The compromised therapeutic efficiency against MDR bacteria and the risk of bacterial evolution due to excessive ...
Wenjie Fan +8 more
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Materials Research Express, 2022 The presented work describes the effect of poly(hexamethylene biguanide) salicylate (PHMB-SA) ionic liquid on the properties of poly(vinyl alcohol) film. The ionic liquid synthetized is used as an antimicrobial agent. The ionic liquid consist of the poly(
Anna Słubik +3 more
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Cellular gene delivery via poly(hexamethylene biguanide)/pDNA self-assembled nanoparticles [PDF]
European Journal of Pharmaceutics and Biopharmaceutics, 2021 Cellular gene delivery via polycations has wide implications for the potential of gene therapy, but it has remained a challenge due to the plethora of pre- and post-uptake barriers that must be overcome to reach desired efficiency. Herein we report poly(hexamethylene biguanide) (PHMB) as a nano-vector for intracellular delivery of plasmid DNA (pDNA ...
Alexandru Chivu +2 more
exaly +4 more sources
In vitro response of THP-1 derived macrophages to antimicrobially effective PHMB-coated Ti6Al4V alloy implant material with and without contamination with S. epidermidis and P. aeruginosa [PDF]
Biomaterials Research, 2022 Aim Periprosthetic joint infections are a devastating complication after arthroplasty, leading to rejection of the prosthesis. The prevention of septic loosening may be possible by an antimicrobial coating of the implant surface.
Paula Zwicker +5 more
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Computational and Theoretical Chemistry, 2022 In the current study, the toxic material Poly-hexamethylene biguanide hydrochloride (PHMB) has been characterized by UV–Visible and infrared spectroscopy in different solvent environments. The nature of the molecular interactions between solvent molecules and PHMB via hydrogen bonds has been investigated using the Atoms in Molecules (AIM) and non ...
Sibel Çelik
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Poly (hexamethylene biguanide), adsorbed onto Ti‐Al‐V alloys, kills slime‐producing Staphylococci and Pseudomonas aeruginosa without inhibiting SaOs‐2 cell differentiation [PDF]
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2019 AbstractAntimicrobial coating of implant material with poly(hexamethylene biguanide) hydrochloride (PHMB) may be an eligible method for preventing implant‐associated infections. In the present study, an antibacterial effective amount of PHMB is adsorbed on the surface of titanium alloy after simple chemical pretreatment.
Melanie Hornschuh +5 more
openaire +3 more sources
Improved Adsorption of the Antimicrobial Agent Poly (Hexamethylene) Biguanide on Ti-Al-V Alloys by NaOH Treatment and Impact of Mass Coverage and Contamination on Cytocompatibility [PDF]
Coatings, 2021 Unlike the native surface of the implant material (Ti6Al4V), oxidation with H2O2 leads to increased binding of the effective antimicrobial agent poly(hexamethylene) biguanide [PHMB]. However, treating with NaOH instead results in an even higher PHMB mass coverage.
Paula Zwicker +2 more
exaly +2 more sources
Organic Polyurethane Surface Structures to Manufacture Noneluting Antimicrobial Polyurethanes: A Systematic Review of Literature. [PDF]
Biomed Res IntThe dramatic increase in hospital‐acquired infections and healthcare costs associated with infection treatment and antimicrobial resistance in implant infections necessitates further research and development of antimicrobial implant material properties. Polyurethanes are key biomaterials used in medical implants and devices.
Hurck BJ +4 more
europepmc +2 more sources
Comparison of the in vitro antibiofilm activities of otic cleansers against canine otitis externa pathogens. [PDF]
Vet DermatolBackground – Biofilm production by canine otitis externa (COE) pathogens and resistance development to multiple antimicrobials are commonly reported problems in veterinary practice. The use of adjuvants to disrupt biofilms may be a viable adjunctive therapy.
Savaliya BF, Kim S, Veltman T, Trott DJ.
europepmc +2 more sources
Effect of combined therapy polyhexamethylene biguanide and Coriolus-MRL on human papilloma virus (HPV) cervical and vulvar-related lesions [PDF]
International Journal of Medical Device and Adjuvant Treatments, 2020 OBJECTIVE: Human papillomavirus (HPV) persistent infections of genital tract are strongly related to the development of genital warts and cellular transformation.
D. Gincheva, V. Gincheva, E. Konova
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