Immunotherapeutic effects of intratumoral nanoplexed poly I:C [PDF]
Journal for ImmunoTherapy of Cancer, 2019 Poly I:C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5 and RIG-I. BO-112 is a nanoplexed formulation of Poly I:C complexed with polyethylenimine that causes tumor cell apoptosis showing immunogenic cell death features and which upon intratumoral release results in more prominent tumor infiltration by T lymphocytes ...
M. Ángela Aznar +15 more
openalex +7 more sources
Poly(I:C) potentiates Bacillus Calmette–Guérin immunotherapy for bladder cancer
Cancer Immunology, Immunotherapy, 2016 Non-specific immunotherapy consisting of intravesical instillation of Bacillus Calmette-Guérin (BCG) is currently the best available treatment to prevent non-muscle-invasive bladder tumor recurrence and progression. This treatment however is suboptimal, and more effective immunotherapeutic approaches are needed.
Chérifa Ayari +5 more
openalex +4 more sources
Sex-specific impact of early life stress on adult lung inflammatory response after LPS and Poly I:C exposures. [PDF]
Brain Behav Immun HealthBouchard K +6 more
europepmc +2 more sources
PLGA-PEI nanoparticle covered with poly(I:C) for personalised cancer immunotherapy. [PDF]
Drug Deliv Transl ResAbstractMelanoma is the main cause of death among skin cancers and its incidence worldwide has been experiencing an appalling increase. However, traditional treatments lack effectiveness in advanced or metastatic patients. Immunotherapy, meanwhile, has been shown to be an effective treatment option, but the rate of cancers responding remains far from ...
Gonzalez-Melero L +7 more
europepmc +5 more sources
Poly I:C induces collective migration of HaCaT keratinocytes via IL-8 [PDF]
BMC Immunology, 2017 Delayed wound healing reduces the quality of life (QOL) of patients. Thus, understanding the mechanism of wound healing is indispensable for better management. However, the role of innate immunity in wound healing is thus far unknown. Recently the involvement of TLR3 in wound healing has been evaluated.
Kazuhide Takada +6 more
openalex +4 more sources
The effects of urolithin A on poly I:C-induced microglial activation. [PDF]
Front Cell NeurosciNeuroinflammation can be triggered by various stimuli, including viral infections. Viruses can directly invade the brain and infect neuronal cells or indirectly trigger a “cytokine storm” in the periphery that eventually leads to microglial activation in the brain.
Mingo YB +5 more
europepmc +6 more sources
Safety Assessment of a Sublingual Vaccine Formulated with Poly(I:C) Adjuvant and Influenza HA Antigen in Mice and Macaque Monkeys: Comparison with Intranasal Vaccine. [PDF]
Vaccines (Basel)Yamamoto T +5 more
europepmc +3 more sources
Targeting SHP-1 to alleviate testicular inflammation and apoptosis in a Poly(I:C)-induced orchitis model. [PDF]
Eur J Med ResWang S, Tong J, Jin B, Lei Q, Zheng Q.
europepmc +3 more sources
Molecular Events in Immune Responses to Sublingual Influenza Vaccine with Hemagglutinin Antigen and Poly(I:C) Adjuvant in Nonhuman Primates, Cynomolgus Macaques. [PDF]
Vaccines (Basel)Yamamoto T +6 more
europepmc +3 more sources
Immunostimulatory activity of polysaccharide–poly(I:C) nanoparticles [PDF]
Biomaterials, 2011 Immunostimulatory properties of mushroom derived polysaccharides (PS) as stand-alone agents were tested. Next, PS were nanocomplexed with polyI:C (pIC) to yield stable nanoparticles around 200 nm in size evidenced by atomic force microscopy and dynamic light scattering analyses.
Tincer G. +6 more
openaire +7 more sources