Results 11 to 20 of about 21,689 (140)

Activation of the NLRP3 inflammasome by intracellular poly I:C [PDF]

FEBS Letters, 2010
Several RNA viruses can be detected by the inflammasome, which promotes IL‐1β and IL‐18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal ...
Rajan, Jayant V., Warren, Sarah E., Miao, Edward A., Aderem, Alan   +3 more
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Immunotherapeutic effects of intratumoral nanoplexed poly I:C [PDF]

Journal for ImmunoTherapy of Cancer, 2019
Poly I:C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5 and RIG-I. BO-112 is a nanoplexed formulation of Poly I:C complexed with polyethylenimine that causes tumor cell apoptosis showing immunogenic cell death features and which upon intratumoral release results in more prominent tumor infiltration by T lymphocytes ...
M. Angela Aznar, Lourdes Planelles, Mercedes Perez-Olivares, Carmen Molina, Saray Garasa, Iñaki Etxeberría, Guiomar Perez, Inmaculada Rodriguez, Elixabet Bolaños, Pedro Lopez-Casas, Maria E. Rodriguez-Ruiz, Jose L. Perez-Gracia, Ivan Marquez-Rodas, Alvaro Teijeira, Marisol Quintero, Ignacio Melero   +15 more
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Immunostimulatory activity of polysaccharide–poly(I:C) nanoparticles [PDF]

Biomaterials, 2011
Immunostimulatory properties of mushroom derived polysaccharides (PS) as stand-alone agents were tested. Next, PS were nanocomplexed with polyI:C (pIC) to yield stable nanoparticles around 200 nm in size evidenced by atomic force microscopy and dynamic light scattering analyses.
Tincer G., Yerlikaya, S., Yagci F.C., Kahraman, T., Atanur O.M., Erbatur O., Gursel I.   +6 more
openaire   +6 more sources

A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
AbstractImmunotherapy is currently under intensive investigation as a potential breakthrough treatment option for glioblastoma. Given the anatomical and immunological complexities surrounding glioblastoma, lymphocytes that infiltrate the brain to develop durable immunity with memory will be key.
Jorrit De Waele, Tias Verhezen, Sanne van der Heijden, Zwi N. Berneman, Marc Peeters, Filip Lardon, An Wouters, Evelien L. J. M. Smits   +7 more
openaire   +4 more sources

Exploiting poly(I:C) to induce cancer cell apoptosis [PDF]

Cancer Biology & Therapy, 2017
TLR3 belong to the Toll-like receptors family, it is mainly expressed on immune cells where it senses pathogen-associated molecular patterns and initiates innate immune response. TLR3 agonist poly(I:C) was developed to mimic pathogens infection and boost immune system activation to promote anti-cancer therapy. Accordingly, TLR agonists were included in
Francesca Bianchi, Samantha Pretto, Elda Tagliabue, Andrea Balsari, Lucia Sfondrini   +4 more
openaire   +3 more sources

Induction of Interferon in Human Subjects by Poly I:C

Experimental Biology and Medicine, 1971
SummaryPoly I:C (rIn:rCn), a synthetic double-stranded polynucleotide previously demonstrated to be a potent inducer of interferon and host resistance to viral infection in cell culture and in animals, has been successfully used to induce interferon in human beings.
A K, Field, C W, Young, I H, Krakoff, A A, Tytell, G P, Lampson, M M, Nemes, M R, Hilleman   +6 more
openaire   +2 more sources

The Effect of Altering the Size of Poly C on the Toxicity and Antigenicity of Poly I:C

Experimental Biology and Medicine, 1972
SummaryAppropriate reduction in size of poly C by degradation with ribonuclease prior to complexing with poly I effected marked reduction in toxicity for mice and antigenicity for rabbits of poly I:C without detectable reduction in in vivo or in vitro protection against viral infection.
G P, Lampson, M M, Nemes, A K, Field, A A, Tytell, M R, Hilleman   +4 more
openaire   +2 more sources

Effect of Poly I:C on Transformation by Rous Sarcoma Virus

Experimental Biology and Medicine, 1972
SummaryTreatment of chick embryo fibroblasts with poly I:C significantly inhibits the ability of RSV to transform and to replicate in these cells. Under identical assay conditions, however, interferon is relatively ineffective in decreasing either of these parameters.
W H, Dodge, C, Moscovici
openaire   +2 more sources

LPS vs. Poly I:C Model

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2022
A prominent health issue nowadays is the COVID-19 pandemic, which poses acute risks to human health. However, the long-term health consequences are largely unknown and cannot be neglected. An especially vulnerable period for infection is pregnancy, when infections could have long-term health effect on the child.
Bao, Mian, Hofsink, Naomi, Plösch, Torsten   +2 more
openaire   +1 more source

The effects of urolithin A on poly I:C-induced microglial activation [PDF]

Frontiers in Cellular Neuroscience
Neuroinflammation can be triggered by various stimuli, including viral infections. Viruses can directly invade the brain and infect neuronal cells or indirectly trigger a “cytokine storm” in the periphery that eventually leads to microglial activation in the brain.
Yakum Benard Mingo, Yakum Benard Mingo, Lea Gabele, Lea Gabele, Niklas Lonnemann, Bert Brône, Martin Korte, Martin Korte, Shirin Hosseini, Shirin Hosseini   +9 more
openaire   +4 more sources