Results 91 to 100 of about 21,689 (140)

The Effect of Actinomycin D on the Lethality of Poly I:C

The Journal of Immunology, 1971
Abstract Poly I:C, a synthetic double-stranded RNA composed of polyinosinic and polycytidylic acids, has become the subject of intense investigation because of its capacity to induce interferon formation and exert antineoplastic activity in experimental animals (1–4).
R E, Pieroni, A E, Bundeally, L, Levine
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To poly(I:C) or not to poly(I:C): Advancing preclinical schizophrenia research through the use of prenatal immune activation models

Neuropharmacology, 2012
The neurodevelopmental hypothesis of schizophrenia has been highly influential in shaping our current thinking about modeling the disease in animals. Based on the findings provided by human epidemiological studies, a great deal of recent interest has been centered upon the establishment of neurodevelopmental rodent models in which the basic ...
Meyer U, Feldon J
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Poly I:C/Poly-L-Lysine: Potent Inducer of Interferons in Primates

Journal of Interferon Research, 1981
A soluble complex of poly I:C and poly-L-lysine (poly I:C/poly-L-lysine) has been prepared that induces high titers of circulating interferon in monkeys. By limiting the molar ratio of lysine to nucleotide to 0.5, a complex was formed that was soluble up to 2.0 mg poly I:C/ml of phosphate-buffered saline.
G P, Lampson, A K, Field, A A, Tytell, M R, Hilleman   +3 more
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The reduction of voluntary physical activity after poly I:C injection is independent of the effect of poly I:C-induced interferon-beta in mice

Physiology & Behavior, 2008
One characteristic of sickness behavior in mice is demonstrated by a reduction in voluntary wheel-running activity during infection. Among synthetic double-stranded (ds) RNAs, polyriboinosinic: polyribocytidylic acid (poly I:C) activates to produce interferon (IFN) -beta, which plays an important role in anti-viral activity and host-defense.
Takashi, Matsumoto, Hiroshi, Takahashi, Daisuke, Shiva, Noriaki, Kawanishi, Michael J, Kremenik, Yasuko, Kato, Hiromi, Yano   +6 more
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Studies on the interaction of Cu2+ and Cd2+ with poly(I:C)

Polyhedron, 1996
Abstract The effect of Cu 2+ and Cd 2+ ions on the double-stranded helical structure of poly(I: C) has been studied by means of absorption spectra, circular dichroism, fluorescent spectra, melting curves and ethidium bromide fluorescent probe.
Erbing Hua, Hongfei Wang, P.I.N. Yang, Binsheng Yang, Jianchao Zong   +4 more
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Poly I:C induces development of diabetes mellitus in BB rat

Diabetes, 1992
Polyinosinic polycytidilic acid (poly I:C), an inducer of α-interferon, accelerates the development of diabetes in diabetes-prone (DP) BioBreeding (BB) rats. This study investigates the effect of administering poly I:C to a diabetes-resistant (DR) strain of BB rats. We compared the incidence of diabetes, the degree of insulitis, the number of NK cells,
D O, Sobel, J, Newsome, C H, Ewel, J A, Bellanti, V, Abbassi, K, Creswell, O, Blair   +6 more
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Effect of Poly I:C/poly-L-lysine (poly ICL) on the Development of Murine Osteogenic Sarcoma

Journal of Interferon Research, 1983
Poly I:C/poly-L-lysine (poly ICL) was effective in preventing or delaying the development of osteogenic sarcoma (OGS) in mice. C57BL/6J mice were inoculated subcutaneously with 5 X 10(4) OGS cells and treatment was evaluated by palpable tumor development and subsequent day of death.
M E, Davies, A K, Field
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Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation

2014
In this chapter, we describe the technique of electroporation as an efficient method to load primary leukemic cells with the double-stranded RNA (dsRNA) analogue, polyriboinosinic polyribocytidylic acid (poly(I:C)), and detail on the delicate freezing and thawing procedure of primary leukemic cells.Electroporation is a non-viral gene transfer method by
Lion, E., de Winde, C.M., de Winde, C.M., Van Tendeloo, V.F., Smits, E.L.   +4 more
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