Results 91 to 100 of about 20,627 (136)

The reduction of voluntary physical activity after poly I:C injection is independent of the effect of poly I:C-induced interferon-beta in mice

Physiology & Behavior, 2008
One characteristic of sickness behavior in mice is demonstrated by a reduction in voluntary wheel-running activity during infection. Among synthetic double-stranded (ds) RNAs, polyriboinosinic: polyribocytidylic acid (poly I:C) activates to produce interferon (IFN) -beta, which plays an important role in anti-viral activity and host-defense.
Takashi, Matsumoto, Hiroshi, Takahashi, Daisuke, Shiva, Noriaki, Kawanishi, Michael J, Kremenik, Yasuko, Kato, Hiromi, Yano   +6 more
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Poly I:C induces development of diabetes mellitus in BB rat

Diabetes, 1992
Polyinosinic polycytidilic acid (poly I:C), an inducer of α-interferon, accelerates the development of diabetes in diabetes-prone (DP) BioBreeding (BB) rats. This study investigates the effect of administering poly I:C to a diabetes-resistant (DR) strain of BB rats. We compared the incidence of diabetes, the degree of insulitis, the number of NK cells,
D O, Sobel, J, Newsome, C H, Ewel, J A, Bellanti, V, Abbassi, K, Creswell, O, Blair   +6 more
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Studies on the interaction of Cu2+ and Cd2+ with poly(I:C)

Polyhedron, 1996
Abstract The effect of Cu 2+ and Cd 2+ ions on the double-stranded helical structure of poly(I: C) has been studied by means of absorption spectra, circular dichroism, fluorescent spectra, melting curves and ethidium bromide fluorescent probe.
Erbing Hua, Hongfei Wang, P.I.N. Yang, Binsheng Yang, Jianchao Zong   +4 more
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Effect of Poly I:C/poly-L-lysine (poly ICL) on the Development of Murine Osteogenic Sarcoma

Journal of Interferon Research, 1983
Poly I:C/poly-L-lysine (poly ICL) was effective in preventing or delaying the development of osteogenic sarcoma (OGS) in mice. C57BL/6J mice were inoculated subcutaneously with 5 X 10(4) OGS cells and treatment was evaluated by palpable tumor development and subsequent day of death.
M E, Davies, A K, Field
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Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation

2014
In this chapter, we describe the technique of electroporation as an efficient method to load primary leukemic cells with the double-stranded RNA (dsRNA) analogue, polyriboinosinic polyribocytidylic acid (poly(I:C)), and detail on the delicate freezing and thawing procedure of primary leukemic cells.Electroporation is a non-viral gene transfer method by
Lion, E., de Winde, C.M., de Winde, C.M., Van Tendeloo, V.F., Smits, E.L.   +4 more
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Reduced-HMGB1 suppresses poly(I:C)-induced inflammation in keratinocytes

Journal of Dermatological Science, 2018
High mobility group box 1 (HMGB1) is a nuclear protein that stabilizes DNA and facilitates gene transcription. Additionally, cell stress or death induces the release of HMGB1 outside the cell membrane, where HMGB1 functions as an alarmin, causing an inflammatory response in combination with other cytokines, damage-associated molecular patterns (DAMPs),
Hideki, Mori, Masamoto, Murakami, Teruko, Tsuda, Kenji, Kameda, Ryo, Utsunomiya, Kana, Masuda, Ken, Shiraishi, Xiuju, Dai, Mikiko, Tohyama, Hiroki, Nakaoka, Koji, Sayama   +10 more
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The effect of Poly I:C and IUDR on the inhibition of HSV in rabbit eyes

Medical Microbiology and Immunology, 1982
The inhibition of herpetic keratitis by a combination of Poly I:C with DEAE-Dextran and IUDR was studied in rabbit eyes. This treatment was administered 72 h after HSV inoculation (daily) for 3 days and continued once daily for another 2-3 days. A significant improvement was detected in rabbit eyes beginning on the first day of treatment, and there was
O, Smetana, E, Eylan, N, Kariv
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Double-Stranded RNAs (Poly I:C) in the Prevention of Viral Infections

Archives of Internal Medicine, 1970
The effective control of viral diseases is a difficult problem and necessitates the exercise of opportunism to explore and utilize all possible approaches. Certain of the viruses for which there is a single or few serotypes lend themselves well to control by vaccines as, eg, poliomyelitis, measles, mumps, rubella, yellow fever, influenza, and smallpox.
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The mechanism of poly I:C-induced antiviral activity in peritoneal macrophage

Archives of Pharmacal Research, 1994
Macrophages play an important role in defense against virus infection by intrinsic resistance and by extrinsic resistance. Since interferon-induced enzymes which are 2'-5' oligoadenylate synthetase and P1/eIF-2 protein kinase have been shown to be involved in the inhibition of viral replication, I examined the mechanism by which poly I:C, an interferon
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Antitumour Effects of Exosomes in Combination with CTX and Poly I:C

Blood, 2008
Abstract Exosomes are vesicles that are approximately 30–100 nm in diameter and are produced by different cell types. Exosomes derived from dendritic cells (DCs) expressing major histocompatibility complex class I/II molecules and T-cell costimulatory molecules are useful in antitumour therapy.
Xiao Li, Huahua Fan, Fang Guo, Chunkang Chang   +3 more
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