Results 101 to 110 of about 21,689 (140)
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The effect of Poly I:C and IUDR on the inhibition of HSV in rabbit eyes
Medical Microbiology and Immunology, 1982The inhibition of herpetic keratitis by a combination of Poly I:C with DEAE-Dextran and IUDR was studied in rabbit eyes. This treatment was administered 72 h after HSV inoculation (daily) for 3 days and continued once daily for another 2-3 days. A significant improvement was detected in rabbit eyes beginning on the first day of treatment, and there was
O, Smetana, E, Eylan, N, Kariv
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Reduced-HMGB1 suppresses poly(I:C)-induced inflammation in keratinocytes
Journal of Dermatological Science, 2018High mobility group box 1 (HMGB1) is a nuclear protein that stabilizes DNA and facilitates gene transcription. Additionally, cell stress or death induces the release of HMGB1 outside the cell membrane, where HMGB1 functions as an alarmin, causing an inflammatory response in combination with other cytokines, damage-associated molecular patterns (DAMPs),
Hideki, Mori +10 more
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Antitumour Effects of Exosomes in Combination with CTX and Poly I:C
Blood, 2008Abstract Exosomes are vesicles that are approximately 30–100 nm in diameter and are produced by different cell types. Exosomes derived from dendritic cells (DCs) expressing major histocompatibility complex class I/II molecules and T-cell costimulatory molecules are useful in antitumour therapy.
Xiao Li +3 more
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Double-Stranded RNAs (Poly I:C) in the Prevention of Viral Infections
Archives of Internal Medicine, 1970The effective control of viral diseases is a difficult problem and necessitates the exercise of opportunism to explore and utilize all possible approaches. Certain of the viruses for which there is a single or few serotypes lend themselves well to control by vaccines as, eg, poliomyelitis, measles, mumps, rubella, yellow fever, influenza, and smallpox.
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The mechanism of poly I:C-induced antiviral activity in peritoneal macrophage
Archives of Pharmacal Research, 1994Macrophages play an important role in defense against virus infection by intrinsic resistance and by extrinsic resistance. Since interferon-induced enzymes which are 2'-5' oligoadenylate synthetase and P1/eIF-2 protein kinase have been shown to be involved in the inhibition of viral replication, I examined the mechanism by which poly I:C, an interferon
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Effect of poly I:C on cell proliferation in vivo.
Archivum immunologiae et therapiae experimentalis, 1978Female Swiss albino mice were injected intraperitoneally with poly I:C1 microgram/g body weight. The animals were killed 2, 12, and 24 hr after the injection of poly I:C. Half an hour before the death of animals they were reinjected intraperitoneally with 3H-thymidine. Fragments of ileum were excised.
M, Kobus, W, Sawicki, M, Korbecki
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Arzneimittel-Forschung, 1986
A new procedure for covalent immobilization of polyriboinosinic-polyribocytidylic acid (poly I:C) on the surface of polymethylmethacrylate (PMMA) is described. Carboxyl groups are generated on the PMMA surface and react with primary amino groups of cytosine. These amino groups are made accessible by heating.
H, Hydén, K, Holmberg
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A new procedure for covalent immobilization of polyriboinosinic-polyribocytidylic acid (poly I:C) on the surface of polymethylmethacrylate (PMMA) is described. Carboxyl groups are generated on the PMMA surface and react with primary amino groups of cytosine. These amino groups are made accessible by heating.
H, Hydén, K, Holmberg
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Differences in the B Cell Interferon Responses to Lipopolysaccharide and Poly I:C
Journal of Interferon Research, 1981Two polyclonal B cell activators, lipopolysaccharide (LPS) and poly I:C, have been used to induce interferon (IFN) production by murine B cell populations. The results show that splenic B cell-enriched fractions, isolated by wheat germ agglutination followed by C-dependent anti-Thy 1.2 cytolysis, respond to treatment with poly I:C + DEAE-dextran by IFN
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VEGF, Poly(i:C), and Innate Immune Response
American Journal of Respiratory and Critical Care Medicine, 2012Laimute, Taraseviciene-Stewart +1 more
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