The Histone 3'-Terminal Stem-Loop-Binding Protein Enhances Translation through a Functional and Physical Interaction with Eukaryotic Initiation Factor 4G (eIF4G) and eIF3 [PDF]
, 2002 Metazoan cell cycle-regulated histone mRNAs are unique cellular mRNAs in that they terminate in a highly conserved stem-loop structure instead of a poly(A) tail.
Gallie, Daniel R +4 more
core +4 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The crystal structure of poly[diaqua-bis(μ 3-5-bromobenzene-1,3-dicarboxylato-κ 3 O,O,O′)-(μ 2-1,3-bis-(4-pyridyl)-propane-κ 2 N,N′)-dizinc(II))] – 5-bromobenzene-1,3-dicarboxylic acid [2/1], C37H29Br3N2O14Zn2 [PDF]
, 2023 Xiao‐Ming Shi, Yu-Jia Fu
openalex +1 more source
An Efficient Parallel Algorithm for Spectral Sparsification of Laplacian and SDDM Matrix Polynomials
, 2015 For "large" class $\mathcal{C}$ of continuous probability density functions (p.d.f.), we demonstrate that for every $w\in\mathcal{C}$ there is mixture of discrete Binomial distributions (MDBD) with $T\geq N\sqrt{\phi_{w}/\delta}$ distinct Binomial ...
Jindal, Gorav, Kolev, Pavel
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Crystal structure of catena-poly[trans-tetraaqua(μ2-1,1′-(biphenyl-4,4′-diyl)bis(1H-imidazol)-k2N:N′)cobalt(II)] dinitrate – 1,1′-(biphenyl-4,4′-diyl)bis(1H-imidazol) – water (1/3/2), C72H68CoN18O12 [PDF]
, 2021 Huixing Li, Xinlong Han, Bin Cao
openalex +1 more source
Synthesis of novel poly(dG)-poly(dG)-poly(dC) triplex structure by Klenow exo− fragment of DNA polymerase I [PDF]
, 2017 The extension of the G-strand of long (700 bp) poly(dG)-poly(dC) by the Klenow exo− fragment of DNA polymerase I yields a complete triplex structure of the H-DNA type.
Borovok, Natalia +5 more
core
The log-convexity of the poly-Cauchy numbers
, 2016 In 2013, Komatsu introduced the poly-Cauchy numbers, which generalize Cauchy numbers. Several generalizations of poly-Cauchy numbers have been considered since then. One particular type of generalizations is that of multiparameter-poly-Cauchy numbers. In
Komatsu, Takao, Zhao, Feng-Zhen
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Stretching of a single-stranded DNA: Evidence for structural transition
, 2009 Recent experiments have shown that the force-extension (F-x) curve for single-stranded DNA (ssDNA) consisting only of adenine [poly(dA)] is significantly different from thymine [poly(dT)].
C. R. Cantor +5 more
core +1 more source