Results 111 to 120 of about 3,561,143 (397)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
SurfacesIt is widely recognized that fine surface structures found in nature contribute to surface functionality, and studies on the design of functional materials based on biomimetics have been actively conducted.
Masahiko Minoda +3 more
doaj +1 more source
mBio, 2010 Maternal infection during pregnancy with a wide range of RNA and DNA viruses is associated with increased risk for schizophrenia and autism in their offspring.
Joari De Miranda +5 more
doaj +1 more source
A 0.026 mm2 Time Domain CMOS Temperature Sensor with Simple Current Source
Micromachines, 2020 This paper presents a time domain CMOS temperature sensor with a simple current source. This sensor chip only occupies a small active die area of 0.026 mm2 because it adopts a simple current source consisting of an n-type poly resistor and a PMOS ...
Sangwoo Park, Sangjin Byun
doaj +1 more source
[Interferon production by various means of administering modified poly I-C].
Voprosy virusologii, 1982 Modified poly(I) . poly(C) induces appreciable amounts of interferon in Macaca rhesus monkeys not only after intravenous but also after intramuscular, endolumbar, and subconjunctival inoculations. The time course and intensity of interferon production after various routes of the induced inoculation were similar.
O G, Andzhaparidze +3 more
openaire +1 more source
Effect of Poly I:C on Experimental Respiratory Infection in Hamsters [PDF]
Applied Microbiology, 1970 The interferon inducer double-stranded polyinosinic acid and polycytidylic acid (poly I:C) was studied in hamsters experimentally infected with parainfluenza 3 virus. Upper intranasal, deep intranasal, or intraperitoneal treatment of hamsters with poly I:C (100 μg/100- to 120-g animal) 24 hr before an upper respiratory infection significantly reduced ...
openaire +2 more sources
, 2006 Polyvinyl alcohol (PVA), PVA crosslinked with glutaraldehyde hydrogels (PVA/GA), PVA with tetraethylorthosilicate (PVA/TEOS) and PVA/GA/TEOS hybrids with recombinant MPB70 protein (rMPB70) incorporated were chemically characterized by Fourier transform ...
Elizabeth Fonseca dos Reis +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Electron correlation in FeSe superconductor studied by bulk-sensitive photoemission spectroscopy
, 2010 We have investigated the electronic structures of recently discovered superconductor FeSe by soft-x-ray and hard-x-ray photoemission spectroscopy with high bulk sensitivity.
A. Higashiya +21 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source