Results 41 to 50 of about 546,465 (315)

Polymeric Forms of Plant Flavonoids Obtained by Enzymatic Reactions

Molecules, 2022
Naringenin is one of the flavonoids originating from citrus fruit. This polyphenol is mainly found in grapefruit, orange and lemon. The antioxidant and antimicrobial properties of flavonoids depend on their structure, including the polymeric form.
Malgorzata Latos-Brozio, Anna Masek, Małgorzata Piotrowska   +2 more
doaj   +1 more source

PROTECTIVE EFFECT OF POLY I:C AGAINST SISOMICIN NEPHBOTOXICITY IN RABBITS [PDF]

Pediatric Research, 1980
The protective effect of Poly I:C during sisomicin nephrotoxicity in rabbits was determined by measurement of the urinary enzymes alkaline phosphatase (AF),lactic dehydrogenase (LDH) and N-a-cetyl-β-glycosaminidase(NAG). 18 rabbits were divided in 3 Groups.
ZEIS, PM, NACOPOULOU, L, GOURIOTIS, D, PIERROUTSAKOS, I, KOUKOUTSAKIS, P, POGAS, N, VLACHOS, P   +6 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

TLR3 Agonist Amplifies the Anti-Inflammatory Potency of ADSCs via IL-10-Mediated Macrophage Polarization in Acute Pancreatitis

Stem Cells International
The immunoregulatory role of mesenchymal stem cells (MSCs) in inflammation is heterogeneous and can exhibit anti-inflammatory or proinflammatory properties depending on the microenvironment. We herein observed that the activation of Toll-like receptor 3 (
Jianxing Liu, Wenjing Yan, Shanshan Chen, Yingjie Sun, Fangfang Zhang, Yue Yang, Liang Jin   +6 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Therapy of Herpetic Keratitis with a Combination of Poly I: C and Idoxuridine

Ophthalmic Research, 1976
Poly I:C-IDU treatment was given to 26 eyes with superficial, and 20 eyes with stromal herpetic keratitis. In superficial keratitis the results were not superior to those of conventional IDU treatment. The favourable results observed in stromal keratitis were attributed to penetration of poly I:C into the corneal stroma, which also can explain the ...
J.A. Oosterhuis, S.H. Sie, W.A. Nolen, J. Versteeg, I.G. Jeltes   +4 more
openaire   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Crystal structure of poly[tetra(μ ₂-cyanido-κ² N:O)-bis(N,N-dimethylformamide-κO)-manganese(II)-platinum(II)], C₁₀H₁₄MnN₆O₂Pt [PDF]

, 2021
Kwang Ha
openalex   +1 more source

Immunostimulatory activity of polysaccharide–poly(I:C) nanoparticles [PDF]

Biomaterials, 2011
Immunostimulatory properties of mushroom derived polysaccharides (PS) as stand-alone agents were tested. Next, PS were nanocomplexed with polyI:C (pIC) to yield stable nanoparticles around 200 nm in size evidenced by atomic force microscopy and dynamic light scattering analyses.
Tincer G., Yerlikaya, S., Yagci F.C., Kahraman, T., Atanur O.M., Erbatur O., Gursel I.   +6 more
openaire   +7 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source